ATE548044T1 - COMBINATION THERAPY FOR THE TREATMENT OF HIV INFECTIONS - Google Patents

COMBINATION THERAPY FOR THE TREATMENT OF HIV INFECTIONS

Info

Publication number
ATE548044T1
ATE548044T1 AT08767561T AT08767561T ATE548044T1 AT E548044 T1 ATE548044 T1 AT E548044T1 AT 08767561 T AT08767561 T AT 08767561T AT 08767561 T AT08767561 T AT 08767561T AT E548044 T1 ATE548044 T1 AT E548044T1
Authority
AT
Austria
Prior art keywords
treatment
present
combination therapy
hiv infections
therapeutic combinations
Prior art date
Application number
AT08767561T
Other languages
German (de)
Inventor
Ann Kwong
Nagraj Mani
Yi Zhou
Chao Lin
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE548044T1 publication Critical patent/ATE548044T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention relates to therapeutic combinations comprising a protease inhibitor and a polymerase inhibitor for the treatment of HCV. The present invention also relates to therapeutic combinations comprising VX-950 and a polymerase inhibitor. Also within the scope of the invention are methods using the therapeutic combinations of the present invention for treating HCV infection or alleviating one or more symptoms thereof in a patient. The present invention also provides kits comprising the combinations of the present invention.
AT08767561T 2007-05-04 2008-05-05 COMBINATION THERAPY FOR THE TREATMENT OF HIV INFECTIONS ATE548044T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92758107P 2007-05-04 2007-05-04
US93142507P 2007-05-23 2007-05-23
PCT/US2008/005758 WO2008137126A2 (en) 2007-05-04 2008-05-05 Combination therapy for the treatment of hcv infection

Publications (1)

Publication Number Publication Date
ATE548044T1 true ATE548044T1 (en) 2012-03-15

Family

ID=39711894

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08767561T ATE548044T1 (en) 2007-05-04 2008-05-05 COMBINATION THERAPY FOR THE TREATMENT OF HIV INFECTIONS

Country Status (11)

Country Link
US (2) US8258116B2 (en)
EP (2) EP2142215B1 (en)
JP (1) JP2010526143A (en)
CN (2) CN101815533A (en)
AT (1) ATE548044T1 (en)
AU (1) AU2008248116A1 (en)
CA (1) CA2686051A1 (en)
ES (1) ES2381410T3 (en)
MX (1) MX2009011930A (en)
NZ (1) NZ580917A (en)
WO (1) WO2008137126A2 (en)

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PT1934179E (en) * 2005-08-19 2010-07-12 Vertex Pharma Processes and intermediates
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
EP2709613B2 (en) * 2011-09-16 2020-08-12 Gilead Pharmasset LLC Methods for treating hcv
PT107924A (en) 2011-10-21 2014-12-03 Abbvie Inc TREATMENT OF AAD COMBINATION (EG WITH ABT-072 OR ABT-333) FOR USE IN HCV TREATMENT
WO2013059630A1 (en) 2011-10-21 2013-04-25 Abbvie Inc. Methods for treating hcv comprising at least two direct acting antiviral agent, ribavirin but not interferon.
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
CN106138080A (en) * 2015-04-03 2016-11-23 南开大学 Nucleoside compound catches the application of medicine in preparation treatment hepatitis C virus (HCV)
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto

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JP2010526143A (en) 2010-07-29

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