ATE52779T1 - Zwischenverbindungen und verfahren fuer die herstellung von antibiotika. - Google Patents
Zwischenverbindungen und verfahren fuer die herstellung von antibiotika.Info
- Publication number
- ATE52779T1 ATE52779T1 AT86305425T AT86305425T ATE52779T1 AT E52779 T1 ATE52779 T1 AT E52779T1 AT 86305425 T AT86305425 T AT 86305425T AT 86305425 T AT86305425 T AT 86305425T AT E52779 T1 ATE52779 T1 AT E52779T1
- Authority
- AT
- Austria
- Prior art keywords
- carbacephalosporins
- trifluoromethylsulfonyloxy
- antibiotics
- manufacture
- processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
- C07D463/16—Nitrogen atoms
- C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
- C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/761,647 US4673737A (en) | 1985-08-02 | 1985-08-02 | 7-acylamino-(or 7-amino)-3-trifluoromethylsulfonyloxy-1-carba(1-dethia)-3-cephem-4-carboxylic acids and esters thereof |
| EP86305425A EP0211540B1 (de) | 1985-08-02 | 1986-07-15 | Zwischenverbindungen und Verfahren für die Herstellung von Antibiotika |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE52779T1 true ATE52779T1 (de) | 1990-06-15 |
Family
ID=25062866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86305425T ATE52779T1 (de) | 1985-08-02 | 1986-07-15 | Zwischenverbindungen und verfahren fuer die herstellung von antibiotika. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4673737A (de) |
| EP (1) | EP0211540B1 (de) |
| JP (2) | JPH0762016B2 (de) |
| KR (1) | KR900001883B1 (de) |
| CN (1) | CN1015103B (de) |
| AT (1) | ATE52779T1 (de) |
| AU (1) | AU586694B2 (de) |
| CA (2) | CA1262356A (de) |
| DE (1) | DE3671225D1 (de) |
| DK (1) | DK335786A (de) |
| ES (1) | ES2000589A6 (de) |
| GR (1) | GR861858B (de) |
| HK (1) | HK3392A (de) |
| HU (1) | HU201932B (de) |
| IE (1) | IE58998B1 (de) |
| IL (1) | IL79421A (de) |
| NZ (1) | NZ216872A (de) |
| PH (1) | PH22722A (de) |
| PT (1) | PT82990B (de) |
| SG (1) | SG78091G (de) |
| SU (1) | SU1547709A3 (de) |
| ZA (1) | ZA865275B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4665171A (en) | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
| US4820816A (en) * | 1985-08-02 | 1989-04-11 | President And Fellows Of Harvard College | 3-trifuoromethylsulfonyloxy-substituted 1-carbacephalosporins as intermediates for antibiotics |
| ATE79119T1 (de) * | 1986-10-03 | 1992-08-15 | Lilly Co Eli | 7-((meta-substituiert)-phenylglycin>-1-carba-1dethia-cephalosporine. |
| EP0299728A3 (de) * | 1987-07-17 | 1989-08-23 | Eli Lilly And Company | Karbonylierungsverfahren für beta-Laktam-Antibiotika |
| US4782144A (en) * | 1987-09-14 | 1988-11-01 | Eli Lilly And Company | 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof |
| US4885291A (en) * | 1988-01-14 | 1989-12-05 | Eli Lilly And Company | 1-carba(dethia)-3-cephem derivatives |
| US5019571A (en) * | 1988-01-25 | 1991-05-28 | Eli Lilly And Company | 1-carbacephalosporin antibiotics |
| US4855418A (en) * | 1988-03-23 | 1989-08-08 | Eli Lilly And Company | Process for production of ceophalosporins |
| US4820832A (en) * | 1988-03-23 | 1989-04-11 | Eli Lilly And Company | Process for preparing 3-unsubstituted cephalosporins and 1-carba(dethia)cephalosporins |
| US4895940A (en) * | 1988-10-19 | 1990-01-23 | Pfizer Inc. | Process for the preparation of penems |
| US4992543A (en) * | 1988-10-19 | 1991-02-12 | Pfizer Inc. | Penem derivatives |
| US5191075A (en) * | 1988-10-19 | 1993-03-02 | Pfizer Inc | Process for the preparation of penems |
| US5225553A (en) * | 1990-09-13 | 1993-07-06 | Eli Lilly And Company | Intermediates to 1-carbacephalosporins and process for preparation thereof |
| US5159073A (en) * | 1990-09-13 | 1992-10-27 | Eli Lilly And Company | Intermediates to 1-carbacephalosporins and process for preparation thereof |
| US5206360A (en) * | 1990-10-22 | 1993-04-27 | Bristol-Myers Squibb Company | Intermediates for cyclobutenedione substituted (1-carba)cephalosporin compounds |
| US5106842A (en) * | 1990-10-22 | 1992-04-21 | Bristol-Myers Squibb Co. | Antibiotic c-3 cyclobutenedione substituted (1-carba)cephalosporin compounds, compositions, and methods of use thereof |
| US5169843A (en) * | 1990-10-22 | 1992-12-08 | Bristol-Myers Squibb Company | Antibiotic C-3 cyclobutenedione substituted (1-carba) cephalosporin compounds, cmpositions, and methods of use thereof |
| US5099015A (en) * | 1991-01-10 | 1992-03-24 | Eli Lilly And Company | Trifluoromethyl 1-carba(1-dethia)cephems |
| US5084447A (en) * | 1991-04-25 | 1992-01-28 | Eli Lilly And Company | C-3 phosphine oxide substituted carbacephalosporins |
| US6204260B1 (en) | 1996-02-23 | 2001-03-20 | Eli Lilly And Company | Non-peptidyl vasopressin V1a antagonists |
| CN107556212B (zh) * | 2017-09-14 | 2020-03-24 | 台州昌霖化工科技有限公司 | 一种制备2-重氮乙酰乙酸对硝基苄酯的方法 |
| CN112500361B (zh) * | 2020-12-27 | 2023-05-12 | 甘肃瀚聚药业有限公司 | 一种(s)-4-苯基-2-恶唑烷酮的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4226866A (en) * | 1972-11-06 | 1980-10-07 | Merck & Co., Inc. | Novel antibiotic analogues of cephalosporins |
| US3925372A (en) * | 1973-02-23 | 1975-12-09 | Lilly Co Eli | Alpha-aminoacyl-3-halo cephalosporins |
| US4275207A (en) * | 1978-08-14 | 1981-06-23 | Merck & Co., Inc. | Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor |
| JPS6058920B2 (ja) * | 1978-12-26 | 1985-12-23 | 協和醗酵工業株式会社 | セフアロスポリン類縁体 |
| NO155548C (no) | 1979-02-10 | 1987-04-15 | Kyowa Hakko Kogyo Kk | Fremgangsmaate til fremstilling av optisk aktive cefalosporin-analoger. |
| JPS60174787A (ja) * | 1984-02-21 | 1985-09-09 | Kyowa Hakko Kogyo Co Ltd | ３位置換カルバセフエム化合物 |
| US4665171A (en) * | 1985-07-17 | 1987-05-12 | Harvard University | Process and intermediates for β-lactam antibiotics |
| IE862850L (en) * | 1985-11-21 | 1987-05-21 | Inst Animal Health Ltd | Intermediates for the preparation of beta-lactam antibiotics |
| JPH0791291B2 (ja) * | 1985-12-30 | 1995-10-04 | イ−ライ・リリ−・アンド・カンパニ− | １−カルバセフアロスポリン抗生物質 |
-
1985
- 1985-08-02 US US06/761,647 patent/US4673737A/en not_active Expired - Fee Related
-
1986
- 1986-07-15 HU HU862912A patent/HU201932B/hu not_active IP Right Cessation
- 1986-07-15 PT PT82990A patent/PT82990B/pt not_active IP Right Cessation
- 1986-07-15 DK DK335786A patent/DK335786A/da not_active Application Discontinuation
- 1986-07-15 EP EP86305425A patent/EP0211540B1/de not_active Expired - Lifetime
- 1986-07-15 DE DE8686305425T patent/DE3671225D1/de not_active Expired - Lifetime
- 1986-07-15 IL IL79421A patent/IL79421A/xx not_active IP Right Cessation
- 1986-07-15 AU AU60149/86A patent/AU586694B2/en not_active Ceased
- 1986-07-15 ZA ZA865275A patent/ZA865275B/xx unknown
- 1986-07-15 AT AT86305425T patent/ATE52779T1/de active
- 1986-07-15 SU SU864027886A patent/SU1547709A3/ru active
- 1986-07-16 PH PH34025A patent/PH22722A/en unknown
- 1986-07-16 CA CA000513962A patent/CA1262356A/en not_active Expired
- 1986-07-16 NZ NZ216872A patent/NZ216872A/xx unknown
- 1986-07-16 JP JP61168983A patent/JPH0762016B2/ja not_active Expired - Lifetime
- 1986-07-16 CN CN86105247A patent/CN1015103B/zh not_active Expired
- 1986-07-16 KR KR1019860005754A patent/KR900001883B1/ko not_active IP Right Cessation
- 1986-07-16 IE IE190186A patent/IE58998B1/en not_active IP Right Cessation
- 1986-07-16 GR GR861858A patent/GR861858B/el unknown
- 1986-07-31 ES ES8600780A patent/ES2000589A6/es not_active Expired
-
1989
- 1989-02-09 CA CA000590674A patent/CA1305964C/en not_active Expired - Lifetime
-
1991
- 1991-09-19 SG SG780/91A patent/SG78091G/en unknown
-
1992
- 1992-01-09 HK HK33/92A patent/HK3392A/xx not_active IP Right Cessation
-
1994
- 1994-12-21 JP JP6318508A patent/JP2529544B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| IL79421A (en) | 1991-06-10 |
| NZ216872A (en) | 1989-10-27 |
| HU201932B (en) | 1991-01-28 |
| KR900001883B1 (ko) | 1990-03-26 |
| CA1262356A (en) | 1989-10-17 |
| HUT41407A (en) | 1987-04-28 |
| KR870002123A (ko) | 1987-03-30 |
| AU586694B2 (en) | 1989-07-20 |
| US4673737A (en) | 1987-06-16 |
| HK3392A (en) | 1992-01-17 |
| DE3671225D1 (de) | 1990-06-21 |
| IE58998B1 (en) | 1993-12-15 |
| EP0211540A1 (de) | 1987-02-25 |
| SG78091G (en) | 1991-11-15 |
| SU1547709A3 (ru) | 1990-02-28 |
| PT82990B (pt) | 1989-01-30 |
| CA1305964C (en) | 1992-08-04 |
| ZA865275B (en) | 1988-02-24 |
| DK335786D0 (da) | 1986-07-15 |
| GR861858B (en) | 1986-11-18 |
| CN86105247A (zh) | 1987-02-04 |
| DK335786A (da) | 1987-02-03 |
| JPH07300475A (ja) | 1995-11-14 |
| EP0211540B1 (de) | 1990-05-16 |
| PH22722A (en) | 1988-11-28 |
| JPH0762016B2 (ja) | 1995-07-05 |
| PT82990A (en) | 1986-08-01 |
| JPS6259277A (ja) | 1987-03-14 |
| JP2529544B2 (ja) | 1996-08-28 |
| AU6014986A (en) | 1987-02-05 |
| ES2000589A6 (es) | 1988-03-01 |
| CN1015103B (zh) | 1991-12-18 |
| IE861901L (en) | 1987-02-02 |
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