ATE512222T1 - MODULATION OF EXPRESSION OF DIACYLGLYCERIN-ACYLTRANSFERASE 2 - Google Patents

MODULATION OF EXPRESSION OF DIACYLGLYCERIN-ACYLTRANSFERASE 2

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Publication number
ATE512222T1
ATE512222T1 AT04779444T AT04779444T ATE512222T1 AT E512222 T1 ATE512222 T1 AT E512222T1 AT 04779444 T AT04779444 T AT 04779444T AT 04779444 T AT04779444 T AT 04779444T AT E512222 T1 ATE512222 T1 AT E512222T1
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Austria
Prior art keywords
expression
modulation
acyltransferase
diacylglycerol acyltransferase
diacylglycerin
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AT04779444T
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German (de)
Inventor
Sanjay Bhanot
Kenneth Dobie
Xing-Xian Yu
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Isis Pharmaceuticals Inc
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Publication of ATE512222T1 publication Critical patent/ATE512222T1/en

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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.

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Abstract

Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided.
AT04779444T 2003-08-18 2004-08-18 MODULATION OF EXPRESSION OF DIACYLGLYCERIN-ACYLTRANSFERASE 2 ATE512222T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/643,801 US7825235B2 (en) 2003-08-18 2003-08-18 Modulation of diacylglycerol acyltransferase 2 expression
PCT/US2004/024384 WO2005019418A2 (en) 2003-08-18 2004-08-18 Modulation of diacylglycerol acyltransferase 2 expression

Publications (1)

Publication Number Publication Date
ATE512222T1 true ATE512222T1 (en) 2011-06-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT04779444T ATE512222T1 (en) 2003-08-18 2004-08-18 MODULATION OF EXPRESSION OF DIACYLGLYCERIN-ACYLTRANSFERASE 2

Country Status (6)

Country Link
US (4) US7825235B2 (en)
EP (2) EP2284267B1 (en)
JP (2) JP2007502616A (en)
AT (1) ATE512222T1 (en)
HK (1) HK1154621A1 (en)
WO (1) WO2005019418A2 (en)

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