ATE502T1 - SALTS OF NON-TOXIC ACTIVATED ANION EXCHANGE RESINS WITH 2-(4'-(P-CHLOROBENZOYL)-PH ENOXY)-2-(METHYL)-PROPIONIC ACID, CAPABLE OF PERMANENT BINDING TO BILATE ACIDS, AND PHARMACEUTICALS CONTAINING THESE SALTS. - Google Patents
SALTS OF NON-TOXIC ACTIVATED ANION EXCHANGE RESINS WITH 2-(4'-(P-CHLOROBENZOYL)-PH ENOXY)-2-(METHYL)-PROPIONIC ACID, CAPABLE OF PERMANENT BINDING TO BILATE ACIDS, AND PHARMACEUTICALS CONTAINING THESE SALTS.Info
- Publication number
- ATE502T1 ATE502T1 AT79104010T AT79104010T ATE502T1 AT E502 T1 ATE502 T1 AT E502T1 AT 79104010 T AT79104010 T AT 79104010T AT 79104010 T AT79104010 T AT 79104010T AT E502 T1 ATE502 T1 AT E502T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- group
- chlorobenzoyl
- resins
- acids
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 231100000252 nontoxic Toxicity 0.000 title abstract 2
- 230000003000 nontoxic effect Effects 0.000 title abstract 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 239000003957 anion exchange resin Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 239000011347 resin Substances 0.000 abstract 5
- 229920005989 resin Polymers 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002672 4-bromobenzoyl group Chemical group BrC1=CC=C(C(=O)*)C=C1 0.000 abstract 1
- 125000000242 4-chlorobenzoyl group Chemical group ClC1=CC=C(C(=O)*)C=C1 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000129 anionic group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000003613 bile acid Substances 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 102000038379 digestive enzymes Human genes 0.000 abstract 1
- 108091007734 digestive enzymes Proteins 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- -1 p-fluorobenzoyl Chemical group 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
- A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B15/00—Preparation of other cellulose derivatives or modified cellulose, e.g. complexes
- C08B15/05—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur
- C08B15/06—Derivatives containing elements other than carbon, hydrogen, oxygen, halogens or sulfur containing nitrogen, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
- C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Phenolic Resins Or Amino Resins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
A non-toxic anionic resin selected from resins having a polymeric reticulated skeleton of styrenic or acrylic type, inert to the digestive enzymes, having a molecular weight higher than 1000 and containing ionizable amino groups, resins having a cellulosic reticulated skeleton modified by the introduction of free or substituted amino groups and resins having a polysaccharide reticulated skeleton modified by the introduction of free or substituted amino groups. The resin is capable of binding itself permanently to the biliary acids and is salified with an acid corresponding to the general formula: <IMAGE> wherein: R' represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, a hydroxyalkyl group having 1 to 3 carbon atoms, R represents a chlorine atom or a group selected from p-chlorobenzoyl, p-bromobenzoyl and p-fluorobenzoyl, W represents a group selected from OH, -N(R''')-CH(R'')-(CH2)n-COOH and O-CH2-COOH wherein n represents a number from 0 to 5, R'' represents a hydrogen atom, a benzyl, a phenyl or a phenyl substituted with an OH group, a lower alkyl, a lower alkoxyl or a lower hydroxyalkyl group and R''' represents a hydrogen atom or a lower alkyl.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT03631/78A IT1106718B (en) | 1978-12-21 | 1978-12-21 | PHARMACOLOGICALLY ACTIVE SALONIZED ANIONIC RESIN BASED COMPOSITIONS |
EP79104010A EP0012804B2 (en) | 1978-12-21 | 1979-10-17 | Salts of a non toxic, activated anion exchange resin capable of establishing a stable binding with bile acids and 2-(4'-(p-chlorobenzoyl)-phenoxy)-2-(methyl)-propionic acid and pharmaceutical compositions comprising these salts |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE502T1 true ATE502T1 (en) | 1982-01-15 |
Family
ID=11110905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT79104010T ATE502T1 (en) | 1978-12-21 | 1979-10-17 | SALTS OF NON-TOXIC ACTIVATED ANION EXCHANGE RESINS WITH 2-(4'-(P-CHLOROBENZOYL)-PH ENOXY)-2-(METHYL)-PROPIONIC ACID, CAPABLE OF PERMANENT BINDING TO BILATE ACIDS, AND PHARMACEUTICALS CONTAINING THESE SALTS. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4340585A (en) |
EP (1) | EP0012804B2 (en) |
JP (1) | JPS55115403A (en) |
AT (1) | ATE502T1 (en) |
DE (1) | DE2961714D1 (en) |
DK (1) | DK159660C (en) |
ES (1) | ES487019A1 (en) |
GR (1) | GR72734B (en) |
IT (1) | IT1106718B (en) |
NO (1) | NO794225L (en) |
YU (1) | YU313079A (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4393145A (en) * | 1979-05-01 | 1983-07-12 | Etablissement Texcontor | Anionic ion exchange resins with cholesterol-decreasing properties |
CH655507B (en) * | 1983-01-12 | 1986-04-30 | ||
US4790991A (en) * | 1985-02-05 | 1988-12-13 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
US4843098A (en) * | 1985-02-05 | 1989-06-27 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
US4818539A (en) * | 1985-02-05 | 1989-04-04 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
US4851392A (en) * | 1985-02-05 | 1989-07-25 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
US4747881A (en) * | 1985-02-05 | 1988-05-31 | Warner-Lambert Company | Ingestible aggregate and delivery system prepared therefrom |
IT1190349B (en) * | 1986-06-16 | 1988-02-16 | Prodotti Formenti Srl | PHARMACEUTICAL COMPOSITIONS WITH SEQUESTRANT ACTIVITY OF BILE ACIDS CONTAINING COLESTYRAMINE AS THE ACTIVE INGREDIENT, AND PROCEDURE TO PREPARE THEM |
US4877775A (en) * | 1986-06-16 | 1989-10-31 | E. I. Du Pont De Nemours And Company | Polymeric aminosaccharides as antihypercholesterolemic agents |
US5451397A (en) * | 1992-12-21 | 1995-09-19 | Rohm And Haas Company | Bile acid sequestrant |
US5498678A (en) * | 1992-12-21 | 1996-03-12 | Rohm And Haas Company | Suspension polymerization process for water-soluble monomers |
US5900475A (en) * | 1994-06-10 | 1999-05-04 | Geltex Pharmaceuticals, Inc. | Hydrophobic sequestrant for cholesterol depletion |
US5618530A (en) * | 1994-06-10 | 1997-04-08 | Geltex Pharmaceuticals, Inc. | Hydrophobic amine polymer sequestrant and method of cholesterol depletion |
US5929184A (en) * | 1993-06-02 | 1999-07-27 | Geltex Pharmaceuticals, Inc. | Hydrophilic nonamine-containing and amine-containing copolymers and their use as bile acid sequestrants |
US5607669A (en) * | 1994-06-10 | 1997-03-04 | Geltex Pharmaceuticals, Inc. | Amine polymer sequestrant and method of cholesterol depletion |
US6129910A (en) * | 1993-06-02 | 2000-10-10 | Geltex Pharmaceuticals, Inc. | Water-insoluble noncrosslinked bile acid sequestrants |
US5703188A (en) * | 1993-06-02 | 1997-12-30 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
US5624963A (en) * | 1993-06-02 | 1997-04-29 | Geltex Pharmaceuticals, Inc. | Process for removing bile salts from a patient and compositions therefor |
TW474813B (en) * | 1994-06-10 | 2002-02-01 | Geltex Pharma Inc | Alkylated composition for removing bile salts from a patient |
US5753262A (en) * | 1995-06-07 | 1998-05-19 | Aronex Pharmaceuticals, Inc. | Cationic lipid acid salt of 3beta N- (N', N'-dimethylaminoethane) - carbamoyl!cholestrol and halogenated solvent-free preliposomal lyophilate thereof |
US6203785B1 (en) | 1996-12-30 | 2001-03-20 | Geltex Pharmaceuticals, Inc. | Poly(diallylamine)-based bile acid sequestrants |
US6423754B1 (en) * | 1997-06-18 | 2002-07-23 | Geltex Pharmaceuticals, Inc. | Method for treating hypercholesterolemia with polyallylamine polymers |
US6726905B1 (en) | 1997-11-05 | 2004-04-27 | Genzyme Corporation | Poly (diallylamines)-based phosphate binders |
US7259186B2 (en) * | 2002-12-17 | 2007-08-21 | Abbott Laboratories | Salts of fenofibric acid and pharmaceutical formulations thereof |
CN101480384A (en) * | 2002-12-17 | 2009-07-15 | 阿伯特有限及两合公司 | Formulation comprising fenofibric acid, a physiologically acceptable salt or derivative thereof |
US20080051411A1 (en) * | 2002-12-17 | 2008-02-28 | Cink Russell D | Salts of Fenofibric Acid and Pharmaceutical Formulations Thereof |
US20080152714A1 (en) * | 2005-04-08 | 2008-06-26 | Yi Gao | Pharmaceutical Formulations |
PL2637646T3 (en) | 2010-11-08 | 2017-01-31 | Albireo Ab | A pharmaceutical combination comprising an ibat inhibitor and a bile acid binder |
DK3400944T3 (en) | 2010-11-08 | 2020-10-12 | Albireo Ab | IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES |
PL2771003T3 (en) | 2011-10-28 | 2017-10-31 | Lumena Pharmaceuticals Llc | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
CN104023718B (en) | 2011-10-28 | 2017-04-05 | 鲁美纳医药公司 | For treating the bile acid recycling inhibitors of high cholemia and cholestatic liver disease |
MX2015013196A (en) | 2013-03-15 | 2016-04-15 | Lumena Pharmaceuticals Inc | Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease. |
CA2907230A1 (en) | 2013-03-15 | 2014-09-18 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease |
CN114096268A (en) | 2019-02-12 | 2022-02-25 | 米鲁姆制药公司 | Methods for increasing growth in pediatric subjects with cholestatic liver disease |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB857194A (en) * | 1957-07-05 | 1960-12-29 | Clinical Products Ltd | Therapeutic agents comprising ion-exchange resins |
BE580490A (en) | 1958-07-15 | 1960-01-08 | Merck & Co Inc | Compositions and methods for lowering the cholesterol content of the blood |
FR4933M (en) * | 1964-09-17 | 1967-03-28 | ||
NL7017227A (en) | 1969-12-27 | 1971-06-29 | ||
GB1348642A (en) * | 1970-10-15 | 1974-03-20 | Howard A N | Hypocholesterolaemic compositions |
US4027009A (en) | 1973-06-11 | 1977-05-31 | Merck & Co., Inc. | Compositions and methods for depressing blood serum cholesterol |
-
1978
- 1978-12-21 IT IT03631/78A patent/IT1106718B/en active
-
1979
- 1979-10-17 EP EP79104010A patent/EP0012804B2/en not_active Expired
- 1979-10-17 DE DE7979104010T patent/DE2961714D1/en not_active Expired
- 1979-10-17 AT AT79104010T patent/ATE502T1/en not_active IP Right Cessation
- 1979-12-11 US US06/102,614 patent/US4340585A/en not_active Expired - Lifetime
- 1979-12-18 ES ES487019A patent/ES487019A1/en not_active Expired
- 1979-12-19 GR GR60803A patent/GR72734B/el unknown
- 1979-12-20 NO NO794225A patent/NO794225L/en unknown
- 1979-12-20 DK DK548279A patent/DK159660C/en not_active IP Right Cessation
- 1979-12-20 JP JP16493279A patent/JPS55115403A/en active Granted
- 1979-12-28 YU YU03130/79A patent/YU313079A/en unknown
Also Published As
Publication number | Publication date |
---|---|
YU313079A (en) | 1983-02-28 |
EP0012804A1 (en) | 1980-07-09 |
DK548279A (en) | 1980-06-22 |
ES487019A1 (en) | 1980-10-01 |
JPS55115403A (en) | 1980-09-05 |
JPS6327362B2 (en) | 1988-06-02 |
EP0012804B1 (en) | 1981-12-30 |
DK159660B (en) | 1990-11-12 |
GR72734B (en) | 1983-12-01 |
EP0012804B2 (en) | 1987-03-04 |
IT7803631A0 (en) | 1978-12-21 |
NO794225L (en) | 1980-06-24 |
US4340585A (en) | 1982-07-20 |
DE2961714D1 (en) | 1982-02-18 |
IT1106718B (en) | 1985-11-18 |
DK159660C (en) | 1991-04-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |