ATE500492T1 - Verfahren und vorrichtung zur bestimmung der wirkung eines medikaments auf zellen - Google Patents

Verfahren und vorrichtung zur bestimmung der wirkung eines medikaments auf zellen

Info

Publication number
ATE500492T1
ATE500492T1 AT00973545T AT00973545T ATE500492T1 AT E500492 T1 ATE500492 T1 AT E500492T1 AT 00973545 T AT00973545 T AT 00973545T AT 00973545 T AT00973545 T AT 00973545T AT E500492 T1 ATE500492 T1 AT E500492T1
Authority
AT
Austria
Prior art keywords
cells
effect
determining
drug
phosphorescence
Prior art date
Application number
AT00973545T
Other languages
English (en)
Inventor
David Wilson
Sergei A Vinogradov
Original Assignee
Phox Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phox Diagnostics Inc filed Critical Phox Diagnostics Inc
Application granted granted Critical
Publication of ATE500492T1 publication Critical patent/ATE500492T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Sustainable Development (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00973545T 1999-10-14 2000-10-13 Verfahren und vorrichtung zur bestimmung der wirkung eines medikaments auf zellen ATE500492T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/418,104 US6395555B1 (en) 1999-10-14 1999-10-14 Method and apparatus for determining the effect of a drug on cells
PCT/US2000/028481 WO2001026609A2 (en) 1999-10-14 2000-10-13 Method and apparatus for determining the effect of a drug on cells

Publications (1)

Publication Number Publication Date
ATE500492T1 true ATE500492T1 (de) 2011-03-15

Family

ID=23656728

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973545T ATE500492T1 (de) 1999-10-14 2000-10-13 Verfahren und vorrichtung zur bestimmung der wirkung eines medikaments auf zellen

Country Status (7)

Country Link
US (1) US6395555B1 (de)
EP (1) EP1224443B1 (de)
AT (1) ATE500492T1 (de)
AU (1) AU781879B2 (de)
CA (1) CA2386842C (de)
DE (1) DE60045687D1 (de)
WO (1) WO2001026609A2 (de)

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JP2004537712A (ja) * 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US20040107986A1 (en) * 2002-12-06 2004-06-10 Neilson Andy C. High throughput microcalorimeter systems and methods
WO2004065618A2 (en) * 2003-01-16 2004-08-05 Thermogenic Imaging Methods and devices for monitoring cellular metabolism in microfluidic cell-retaining chambers
JP2006522329A (ja) * 2003-03-07 2006-09-28 ラクセル・バイオサイエンシズ・リミテッド 酸素感受性プローブ
US7276351B2 (en) * 2003-09-10 2007-10-02 Seahorse Bioscience Method and device for measuring multiple physiological properties of cells
US20050084914A1 (en) * 2003-09-15 2005-04-21 Foulkes J. G. Assays with primary cells
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
US20070087401A1 (en) * 2003-10-17 2007-04-19 Andy Neilson Analysis of metabolic activity in cells using extracellular flux rate measurements
US8658349B2 (en) 2006-07-13 2014-02-25 Seahorse Bioscience Cell analysis apparatus and method
US8129684B2 (en) * 2005-03-22 2012-03-06 Coherent, Inc. Detection of hidden objects by terahertz heterodyne laser imaging
CN102254150A (zh) 2005-10-14 2011-11-23 尤尼森斯繁殖技术公司 细胞群的变化的测定
US7575890B2 (en) * 2006-01-18 2009-08-18 Oxygen Enterprises, Ltd. Method for rapid detection and evaluation of cultured cell growth
EP2043694A2 (de) * 2006-07-24 2009-04-08 University College Cork - National University of Ireland, Cork Sonde für zellulären sauerstoff
US7598381B2 (en) * 2006-09-11 2009-10-06 The Trustees Of Princeton University Near-infrared emitting organic compounds and organic devices using the same
US8633017B2 (en) 2007-06-29 2014-01-21 Unisense Fertilitech A/S Device, a system and a method for monitoring and/or cultivation of microscopic objects
US8202702B2 (en) * 2008-10-14 2012-06-19 Seahorse Bioscience Method and device for measuring extracellular acidification and oxygen consumption rate with higher precision
US8323978B2 (en) * 2008-11-07 2012-12-04 Mocon, Inc. Calibration system and technique for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
US8241911B2 (en) * 2008-11-07 2012-08-14 Mocon, Inc. Calibration card for photoluminescent oxygen sensors with zero point maintained with a metal-air battery
WO2010053888A1 (en) * 2008-11-07 2010-05-14 Mocon, Inc Calibration card for oxygen optical sensors
US20110136247A1 (en) * 2009-12-07 2011-06-09 Dmitri Boris Papkovsky Photoluminescent oxygen probe with reduced cross-sensitivity to humidity
DE102010037923B4 (de) * 2010-10-01 2015-08-27 Elmar Schmälzlin Vorrichtung und Verfahren zur Sauerstoffmessung
US10508992B2 (en) 2010-10-22 2019-12-17 University College Cork, National University of Ir Cork Method and probe for monitoring oxygen status in live mammalian cells
US9274060B1 (en) 2011-01-13 2016-03-01 Mocon, Inc. Methods for transmembrane measurement of oxygen concentration and monitoring changes in oxygen concentration within a space enclosed by a membrane employing a photoluminescent transmembrane oxygen probe
US9121827B2 (en) 2011-06-30 2015-09-01 Mocon, Inc. Method of contemporaneously monitoring changes in analyte concentration in a plurality of samples on individual schedules
US10955291B2 (en) * 2012-03-15 2021-03-23 Amgen Inc. Methods of determining exposure to UV light
US9057687B2 (en) 2012-04-20 2015-06-16 Mocon, Inc. Calibration vial and technique for calibrating a fiber optic oxygen sensing needle
US8658429B1 (en) 2012-08-06 2014-02-25 Mocon, Inc. Photoluminescent oxygen probe tack
US11109458B2 (en) 2012-11-08 2021-08-31 Applied Biophotonics Ltd. Phototherapy system with dynamic drive for light-emitting diodes
US10328276B2 (en) * 2014-02-14 2019-06-25 Applied Biophotonics Ltd. Sinusoidal drive system and method for phototherapy
US9494577B2 (en) 2012-11-13 2016-11-15 Seahorse Biosciences Apparatus and methods for three-dimensional tissue measurements based on controlled media flow
JP6483681B2 (ja) * 2013-07-29 2019-03-13 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 刺激を動的に変化させるリアルタイムフィードバックシステム制御技術プラットホーム
EP2924111A1 (de) * 2014-03-24 2015-09-30 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Verfahren und system zur kontinuierlichen überwachung der toxizität
JP6739351B2 (ja) 2014-06-02 2020-08-12 シーホース バイオサイエンス インコーポレイテッド 生物試料分析用の単一列マイクロプレートシステム及び搬送体
US11988583B2 (en) 2018-08-31 2024-05-21 Lucid Scientific, Inc. Measurement of a dynamic system

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US4476870A (en) 1982-03-30 1984-10-16 The United States Of America As Represented By The Department Of Health And Human Services Fiber optic PO.sbsb.2 probe
US4947850A (en) 1988-03-11 1990-08-14 Trustees Of The University Of Pennsylvania Method and apparatus for imaging an internal body portion of a host animal
US5186173A (en) 1990-08-14 1993-02-16 Drexel University Method for in vivo measurement of oxygen concentration levels
US5149801A (en) 1990-11-21 1992-09-22 The Regents Of The University Of California Boronated porphyrin compounds
US5279297A (en) 1991-09-20 1994-01-18 Trustees Of The University Of Pennsylvania Method and apparatus for oxygen mapping
US5501225A (en) 1991-09-20 1996-03-26 Wilson; David F. Imaging of tissue oxygen using needle phosphorimeter
US5515864A (en) * 1994-04-21 1996-05-14 Zuckerman; Ralph Method and apparatus for the in vivo measurement of oxygen concentration levels by the indirect determination of fluoescence lifetime
US5792426A (en) * 1994-10-11 1998-08-11 Schweizerische Eidgenossenschaft Vertreten Durch Das Ac-Laboratorium Spiez Der Gruppe Rustung Multi-well titerplate for instrumental analysis
WO1998015645A1 (en) * 1996-10-08 1998-04-16 Photonics Biosystems Microbiological assessment method and device utilizing oxygen gradient sensing
US5830138A (en) 1996-12-16 1998-11-03 Trustees Of The University Of Pennsylvania Intravascular catheter probe for clinical oxygen, pH and CO2 measurement
US5908776A (en) 1998-04-06 1999-06-01 Pharmacopeia, Inc. Cell culture chamber for multiple well plates

Also Published As

Publication number Publication date
AU1204601A (en) 2001-04-23
WO2001026609A2 (en) 2001-04-19
CA2386842A1 (en) 2001-04-19
EP1224443B1 (de) 2011-03-02
DE60045687D1 (de) 2011-04-14
CA2386842C (en) 2012-05-15
EP1224443A2 (de) 2002-07-24
US6395555B1 (en) 2002-05-28
AU781879B2 (en) 2005-06-16
WO2001026609A3 (en) 2002-01-10
EP1224443A4 (de) 2005-01-12

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