ATE495283T1 - Proteinkristall mit dem prozessivitätsklemmfaktor von dna-polymerase und einem liganden und verwendungen dafür - Google Patents

Proteinkristall mit dem prozessivitätsklemmfaktor von dna-polymerase und einem liganden und verwendungen dafür

Info

Publication number
ATE495283T1
ATE495283T1 AT04740348T AT04740348T ATE495283T1 AT E495283 T1 ATE495283 T1 AT E495283T1 AT 04740348 T AT04740348 T AT 04740348T AT 04740348 T AT04740348 T AT 04740348T AT E495283 T1 ATE495283 T1 AT E495283T1
Authority
AT
Austria
Prior art keywords
dna polymerase
pol
coli
processivity clamp
clamp factor
Prior art date
Application number
AT04740348T
Other languages
English (en)
Inventor
Dominique Burnouf
Jerome Wagner
Philippe Dumas
Shingo Fujii
Robert Fuchs
Vincent Olieric
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE495283T1 publication Critical patent/ATE495283T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C12N9/1252—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07007—DNA-directed DNA polymerase (2.7.7.7), i.e. DNA replicase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT04740348T 2003-06-27 2004-06-25 Proteinkristall mit dem prozessivitätsklemmfaktor von dna-polymerase und einem liganden und verwendungen dafür ATE495283T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20030291596 EP1492038A1 (de) 2003-06-27 2003-06-27 Kristallisiertes Protein des Prozessivitätsklammer-Faktors der DNA Polymerase, ein Ligand und deren Verwendung
PCT/EP2004/006942 WO2005001084A2 (en) 2003-06-27 2004-06-25 Protein crystal comprising the processivity clamp factor of dna polymerase and a ligand, and its uses

Publications (1)

Publication Number Publication Date
ATE495283T1 true ATE495283T1 (de) 2011-01-15

Family

ID=33396066

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04740348T ATE495283T1 (de) 2003-06-27 2004-06-25 Proteinkristall mit dem prozessivitätsklemmfaktor von dna-polymerase und einem liganden und verwendungen dafür

Country Status (6)

Country Link
US (1) US7635583B2 (de)
EP (2) EP1492038A1 (de)
AT (1) ATE495283T1 (de)
CA (1) CA2530667C (de)
DE (1) DE602004031012D1 (de)
WO (1) WO2005001084A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100465643C (zh) * 2007-03-19 2009-03-04 南开大学 从中药等天然产物混合体系中高效、快速获取靶分子与靶蛋白复合体精细三维结构的新方法
EP2511290A1 (de) 2011-04-15 2012-10-17 Centre National de la Recherche Scientifique Verbindungen zur Bindung des bakteriellen Beta-Rings

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1479802A (en) * 2000-11-08 2002-05-21 Commw Scient Ind Res Org Method of identifying antibacterial compounds
WO2003025004A2 (en) * 2001-09-18 2003-03-27 Affinium Pharmaceuticals, Inc. Purified bacterial polypeptides involved in nucleic acid processing

Also Published As

Publication number Publication date
EP1492038A1 (de) 2004-12-29
CA2530667A1 (en) 2005-01-06
DE602004031012D1 (de) 2011-02-24
CA2530667C (en) 2013-04-23
EP1639509B1 (de) 2011-01-12
US7635583B2 (en) 2009-12-22
EP1639509A2 (de) 2006-03-29
WO2005001084A3 (en) 2005-02-24
WO2005001084A2 (en) 2005-01-06
US20070275898A1 (en) 2007-11-29

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