ATE495160T1 - Kristallines 1-(cyclohexyloxycarbonyloxy)-ethyl 1-((2'-cyanobiphenyl-4-yl)-methyl)-2-ethoxy-1h- benzo-ädü-imidazol-7-carboxylat und verfahren zu seiner herstellung - Google Patents
Kristallines 1-(cyclohexyloxycarbonyloxy)-ethyl 1-((2'-cyanobiphenyl-4-yl)-methyl)-2-ethoxy-1h- benzo-ädü-imidazol-7-carboxylat und verfahren zu seiner herstellungInfo
- Publication number
- ATE495160T1 ATE495160T1 AT08749704T AT08749704T ATE495160T1 AT E495160 T1 ATE495160 T1 AT E495160T1 AT 08749704 T AT08749704 T AT 08749704T AT 08749704 T AT08749704 T AT 08749704T AT E495160 T1 ATE495160 T1 AT E495160T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclohexyloxycarbonyloxy
- cyanobiphenyl
- benzo
- imidazole
- carboxylate
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- -1 1-(CYCLOHEXYLOXYCARBONYLOXY)-ETHYL Chemical class 0.000 title 1
- GHOSNRCGJFBJIB-UHFFFAOYSA-N Candesartan cilexetil Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C3=NNN=N3)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 GHOSNRCGJFBJIB-UHFFFAOYSA-N 0.000 abstract 3
- 229960004349 candesartan cilexetil Drugs 0.000 abstract 3
- SIQUUIKHTASBBJ-UHFFFAOYSA-N 1-cyclohexyloxycarbonyloxyethyl 3-[[4-(2-cyanophenyl)phenyl]methyl]-2-ethoxybenzimidazole-4-carboxylate Chemical compound C=12N(CC=3C=CC(=CC=3)C=3C(=CC=CC=3)C#N)C(OCC)=NC2=CC=CC=1C(=O)OC(C)OC(=O)OC1CCCCC1 SIQUUIKHTASBBJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI200700100A SI22488A (sl) | 2007-04-24 | 2007-04-24 | Kristalni 1-(cikloheksiloksikarboniloksi)etil 1-((2'-cianobifenil-4-il)metil) - 2-etoksi-1h-benz(d)imidazol -7-karboksilat in proces za njegovo pripravo |
| PCT/EP2008/054997 WO2008129077A2 (en) | 2007-04-24 | 2008-04-24 | Crystalline 1-(cyclohexyloxycarbonyloxy) ethyl 1-((2'-cyanobiphenyl-4-yl)methyl)-2-ethoxy-1h-benzo[d]imidazole-7-carboxylate and a process for its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495160T1 true ATE495160T1 (de) | 2011-01-15 |
Family
ID=39671465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08749704T ATE495160T1 (de) | 2007-04-24 | 2008-04-24 | Kristallines 1-(cyclohexyloxycarbonyloxy)-ethyl 1-((2'-cyanobiphenyl-4-yl)-methyl)-2-ethoxy-1h- benzo-ädü-imidazol-7-carboxylat und verfahren zu seiner herstellung |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP2139866B1 (de) |
| CN (1) | CN101679300A (de) |
| AT (1) | ATE495160T1 (de) |
| DE (1) | DE602008004486D1 (de) |
| EA (1) | EA200901295A1 (de) |
| PL (1) | PL2139866T3 (de) |
| SI (2) | SI22488A (de) |
| UA (1) | UA98140C2 (de) |
| WO (1) | WO2008129077A2 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103073537A (zh) * | 2013-02-01 | 2013-05-01 | 武汉工程大学 | 坎地沙坦酯的合成工艺 |
| CN103724277A (zh) * | 2014-01-20 | 2014-04-16 | 华润赛科药业有限责任公司 | 一种阿齐沙坦中间体的制备方法 |
| CN104788429B (zh) * | 2015-03-06 | 2018-07-06 | 浙江美诺华药物化学有限公司 | 一种通过脱除三苯甲基保护基制备沙坦类药物的方法 |
| CN107089972B (zh) * | 2017-06-23 | 2021-05-18 | 浙江华海药业股份有限公司 | 一种坎地沙坦酯的制备方法 |
| CN113456601A (zh) * | 2021-05-26 | 2021-10-01 | 江苏宇锐医药科技有限公司 | 一种坎地沙坦酯氢氯噻嗪复方片剂的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| CN1204125C (zh) * | 2000-12-27 | 2005-06-01 | 中国科学院上海药物研究所 | 坎地沙坦酯的合成新路线 |
| CN1425654A (zh) * | 2003-01-07 | 2003-06-25 | 江苏省药物研究所 | 一种2－烷氧基苯并咪唑类化合物的制备方法 |
| TWI346108B (en) * | 2004-08-23 | 2011-08-01 | Bristol Myers Squibb Co | A method for preparing irbesartan and intermediates thereof |
| EP1764365A1 (de) * | 2005-09-20 | 2007-03-21 | KRKA, D.D., Novo Mesto | Verfahren zur Herstellung Sartanderivate und Zwischenprodukte für dieses Verfahren |
-
2007
- 2007-04-24 SI SI200700100A patent/SI22488A/sl not_active IP Right Cessation
-
2008
- 2008-04-24 PL PL08749704T patent/PL2139866T3/pl unknown
- 2008-04-24 EA EA200901295A patent/EA200901295A1/ru unknown
- 2008-04-24 CN CN200880012940A patent/CN101679300A/zh active Pending
- 2008-04-24 UA UAA200910746A patent/UA98140C2/ru unknown
- 2008-04-24 EP EP08749704A patent/EP2139866B1/de active Active
- 2008-04-24 WO PCT/EP2008/054997 patent/WO2008129077A2/en not_active Ceased
- 2008-04-24 SI SI200830176T patent/SI2139866T1/sl unknown
- 2008-04-24 AT AT08749704T patent/ATE495160T1/de not_active IP Right Cessation
- 2008-04-24 DE DE602008004486T patent/DE602008004486D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008129077A3 (en) | 2009-01-29 |
| EA200901295A1 (ru) | 2010-04-30 |
| PL2139866T3 (pl) | 2011-04-29 |
| EP2139866A2 (de) | 2010-01-06 |
| WO2008129077A2 (en) | 2008-10-30 |
| SI22488A (sl) | 2008-10-31 |
| DE602008004486D1 (de) | 2011-02-24 |
| EP2139866B1 (de) | 2011-01-12 |
| CN101679300A (zh) | 2010-03-24 |
| SI2139866T1 (sl) | 2011-04-29 |
| UA98140C2 (ru) | 2012-04-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |