ATE489T1 - SILA-SUBSTITUTED 1,4-DIHYDROPYRIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, MEDICATIONS AND PROCESS FOR THEIR PRODUCTION. - Google Patents

SILA-SUBSTITUTED 1,4-DIHYDROPYRIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, MEDICATIONS AND PROCESS FOR THEIR PRODUCTION.

Info

Publication number
ATE489T1
ATE489T1 AT79102963T AT79102963T ATE489T1 AT E489 T1 ATE489 T1 AT E489T1 AT 79102963 T AT79102963 T AT 79102963T AT 79102963 T AT79102963 T AT 79102963T AT E489 T1 ATE489 T1 AT E489T1
Authority
AT
Austria
Prior art keywords
production
derivatives
sila
substituted
dihydropyride
Prior art date
Application number
AT79102963T
Other languages
German (de)
Inventor
Reinhold Dr. Tacke
Anke Bentlage
Robertson Dr. Towart
Wulf Dr. Vater
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of ATE489T1 publication Critical patent/ATE489T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention provides sila-substituted 1,4-dihydropyridine derivatives useful as medicament which influence the circulation. Also included in the invention are methods for the procurement of said derivatives, compositions containing said derivatives and methods for the use of said derivatives.
AT79102963T 1978-08-28 1979-08-20 SILA-SUBSTITUTED 1,4-DIHYDROPYRIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, MEDICATIONS AND PROCESS FOR THEIR PRODUCTION. ATE489T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782837477 DE2837477A1 (en) 1978-08-28 1978-08-28 SILA-SUBSTITUTED 1,4-DIHYDROPYRIDINE DERIVATIVES
EP79102963A EP0010130B1 (en) 1978-08-28 1979-08-20 Sila-substituted 1,4-dihydropyridine derivatives, processes for their preparation, pharmaceutical compositions and process for their preparation

Publications (1)

Publication Number Publication Date
ATE489T1 true ATE489T1 (en) 1982-01-15

Family

ID=6048072

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79102963T ATE489T1 (en) 1978-08-28 1979-08-20 SILA-SUBSTITUTED 1,4-DIHYDROPYRIDE DERIVATIVES, PROCESS FOR THEIR PRODUCTION, MEDICATIONS AND PROCESS FOR THEIR PRODUCTION.

Country Status (8)

Country Link
US (1) US4237137A (en)
EP (1) EP0010130B1 (en)
JP (1) JPS5533497A (en)
AT (1) ATE489T1 (en)
CA (1) CA1135699A (en)
DE (2) DE2837477A1 (en)
ES (1) ES483661A1 (en)
IL (1) IL58103A (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2915355A1 (en) * 1979-04-14 1980-10-23 Nattermann A & Cie NEW 1,4-DIHYDROPYRIDINE BERIVATIVES WITH ANTI-HYPERTENSIVE EFFECT
US4325389A (en) * 1980-09-22 1982-04-20 Cordis Corporation Tip assembly for a carbon fiber implantable lead
DE3339236A1 (en) * 1983-10-28 1985-05-09 Bayer Ag PREPARATION OF MEDICINAL PRODUCTS
DE3433239A1 (en) * 1984-09-11 1986-03-20 Bayer Ag, 5090 Leverkusen SOLID PHARMACEUTICAL PREPARATION CONTAINING NITRENDIPINE AND METHOD FOR THE PRODUCTION THEREOF
US4593033A (en) * 1985-04-24 1986-06-03 Merck & Co., Inc. Substituted indeno[2,1-c] pyridines useful as calcium channel blockers
US4605660A (en) * 1985-06-03 1986-08-12 Merck & Co., Inc. Indeno[2,1-c]pyridine compounds, and their use as calcium channel blockers
US4670443A (en) * 1985-07-02 1987-06-02 Merck & Co., Inc. Benzo(f)isoquinoline compounds useful as calcium entry blockers
US4735956A (en) * 1985-09-13 1988-04-05 Merck & Co., Inc. Certain 1,4-dihydro-2,6-di-lower hydrocarbyl-4-heterocyclic-3,5-pyridine dicarboxylates which are useful as calcium channel blockers
DE3677319D1 (en) * 1985-10-22 1991-03-07 Sanwa Kagaku Kenkyusho Co PHARMACEUTICAL 1,4-DIHYDROPYRIDINE DERIVATIVES, THEIR SALTS AND PRODUCTION.
US4721708A (en) * 1985-11-26 1988-01-26 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds and cardiovascular use
US4788203A (en) * 1985-11-26 1988-11-29 Merck & Co., Inc. Cyclized N-substituted-tetrahydropyridine compounds, useful in the treatment of cardiovascular disorders
US4841054A (en) * 1986-10-21 1989-06-20 Lukevits Edmund Y 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(5'-trimethylsilyl-2'-furyl)-1,4-dihydropyridine
DE102005056050A1 (en) * 2005-11-24 2007-05-31 Wacker Chemie Ag New alpha-(beta-ketocarbonyl)-functional organosilicon compound useful in an aqueous solution together with an aminopolysiloxane in the manufacture of elastomer film

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3355455A (en) * 1964-08-06 1967-11-28 Dow Corning Certain pyridyl silane derivatives
US3816439A (en) * 1970-06-19 1974-06-11 Monsanto Co Substituted 1,2-dihydropyridines and process for preparing same
DE2117571C3 (en) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Asymmetrical 1,4-dihydropyridine-33-dicarboxylic acid esters, process for their preparation and their use as pharmaceuticals
US3781291A (en) * 1971-05-26 1973-12-25 R Sulzbach Silylated 1,4-dihydropyridines
US4031104A (en) * 1972-04-18 1977-06-21 Bayer Aktiengesellschaft 1,4-Dihydropyridine carboxylic acid esters
DE2248150A1 (en) * 1972-09-30 1974-04-04 Bayer Ag DIHYDROPYRIDINE POLYESTER, METHOD FOR MANUFACTURING AND USING THEM AS A MEDICINAL PRODUCT
DE2508181A1 (en) * 1975-02-26 1976-09-09 Bayer Ag 1,4-DIHYDROPYRIDINCARBONIC ACID ARAL KYLESTER, METHOD FOR MANUFACTURING AND USING THEY AS A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
EP0010130B1 (en) 1981-12-23
JPS6217595B2 (en) 1987-04-18
DE2961609D1 (en) 1982-02-11
DE2837477A1 (en) 1980-03-13
US4237137A (en) 1980-12-02
IL58103A (en) 1983-06-15
EP0010130A1 (en) 1980-04-30
JPS5533497A (en) 1980-03-08
ES483661A1 (en) 1980-04-16
IL58103A0 (en) 1979-12-30
CA1135699A (en) 1982-11-16

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