ATE478086T1 - Neue s-adenosyl-l-methioninanaloga mit verlängerten aktivierten gruppen zum transfer durch methyltransferasen - Google Patents

Neue s-adenosyl-l-methioninanaloga mit verlängerten aktivierten gruppen zum transfer durch methyltransferasen

Info

Publication number
ATE478086T1
ATE478086T1 AT06753389T AT06753389T ATE478086T1 AT E478086 T1 ATE478086 T1 AT E478086T1 AT 06753389 T AT06753389 T AT 06753389T AT 06753389 T AT06753389 T AT 06753389T AT E478086 T1 ATE478086 T1 AT E478086T1
Authority
AT
Austria
Prior art keywords
carbon
adenosyl
transfer
new
double bond
Prior art date
Application number
AT06753389T
Other languages
English (en)
Inventor
Elmar Weinhold
Christian Dalhoff
Saulius Klimasauskas
G Lukinavicius
Original Assignee
Rwth Aachen
Inst Of Biotechnology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rwth Aachen, Inst Of Biotechnology filed Critical Rwth Aachen
Application granted granted Critical
Publication of ATE478086T1 publication Critical patent/ATE478086T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06753389T 2005-04-14 2006-04-13 Neue s-adenosyl-l-methioninanaloga mit verlängerten aktivierten gruppen zum transfer durch methyltransferasen ATE478086T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05008226A EP1712557A1 (de) 2005-04-14 2005-04-14 S-Adenosyl-L-Methionine Analoge mit verlängerten aktivierten Gruppen zur Übertragung mit Methyltransferasen
PCT/EP2006/003463 WO2006108678A2 (en) 2005-04-14 2006-04-13 New s-adenosyl-l-methionine analogs with extended activated groups for transfer by methyltransferases

Publications (1)

Publication Number Publication Date
ATE478086T1 true ATE478086T1 (de) 2010-09-15

Family

ID=34981211

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06753389T ATE478086T1 (de) 2005-04-14 2006-04-13 Neue s-adenosyl-l-methioninanaloga mit verlängerten aktivierten gruppen zum transfer durch methyltransferasen

Country Status (6)

Country Link
US (1) US8008007B2 (de)
EP (2) EP1712557A1 (de)
JP (1) JP5129120B2 (de)
AT (1) ATE478086T1 (de)
DE (1) DE602006016259D1 (de)
WO (1) WO2006108678A2 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1712557A1 (de) 2005-04-14 2006-10-18 RWTH Aachen S-Adenosyl-L-Methionine Analoge mit verlängerten aktivierten Gruppen zur Übertragung mit Methyltransferasen
JP4966886B2 (ja) * 2008-02-12 2012-07-04 富士フイルム株式会社 感光性組成物、該感光性組成物を用いたパターン形成方法及び該感光性組成物に用いられる化合物
US20110177508A1 (en) 2008-07-22 2011-07-21 Bestor Timothy H Universal methylation profiling methods
LT5708B (en) 2009-04-02 2011-01-25 Biotechnologijos Inst Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases
WO2011150475A1 (en) 2010-06-04 2011-12-08 Katholieke Universiteit Leuven K.U. Leuven R&D Optical mapping of genomic dna
GB2500501A (en) * 2010-11-05 2013-09-25 Baker Hughes Inc An apparatus, system and method for estimating a property of a downhole fluid
AT511856A1 (de) * 2011-09-01 2013-03-15 Univ Graz Tech Mittel und verfahren zur alkylierung
GB201119904D0 (en) * 2011-11-17 2011-12-28 Univ Vilnius Analysis of methylation sites
GB201119903D0 (en) 2011-11-17 2011-12-28 Univ Vilnius Nucleic acid production and sequence analysis
US20130288264A1 (en) * 2011-12-16 2013-10-31 The Regents Of The University Of California Development of a New Isolation Method with Higher Selectivity and Efficiency
WO2013148727A1 (en) * 2012-03-26 2013-10-03 The Regents Of The University Of California Preparation of functionalized polypeptides, peptides, and proteins by alkylation of thioether groups
DE102012222675A1 (de) 2012-12-10 2014-06-12 Universität Hamburg Mittel und Verfahren zur Modifizierung der 5'-Kappe von RNA
EP3010929A4 (de) * 2013-06-17 2017-02-22 The Trustees of Columbia University in the City of New York Universelle methylierungsprofilierungsverfahren
US10337049B2 (en) 2013-06-17 2019-07-02 The Trustees Of Columbia University In The City Of New York Universal methylation profiling methods
WO2015126840A1 (en) 2014-02-18 2015-08-27 Bionano Genomics, Inc. Improved methods of determining nucleic acid structural information
GB201415349D0 (en) 2014-08-29 2014-10-15 Univ Leuven Kath Cofactor analogues for methyltransferases
LT6341B (lt) * 2015-03-19 2016-12-27 Vilniaus Universitetas Viengrandės rnr analizė
CN106831781B (zh) * 2015-12-04 2019-05-14 中国科学院大连化学物理研究所 一种荧光探针nasa及其制备和应用
WO2017161296A1 (en) * 2016-03-17 2017-09-21 Northwestern University Antibiotic-coated nanoparticles
EP3448872A4 (de) 2016-04-27 2019-12-11 The Regents of the University of California Herstellung von funktionellen homocysteinresten in polypeptiden und peptiden
EP3497239A4 (de) 2016-08-10 2020-02-26 Ramot at Tel-Aviv University Ltd. Analyse des methylierungsstatus und kopienzahl
GB201913598D0 (en) * 2019-09-20 2019-11-06 Univ Birmingham Labelling of biomolecules
EP4174189A1 (de) 2021-10-28 2023-05-03 Volker, Leen Enzymgerichtete biomolekülmarkierung
CN115266977B (zh) * 2022-07-25 2024-02-27 山东普洛汉兴医药有限公司 一种测定dl-对氯苯丝氨酸乙酯含量的hplc方法
GB202306717D0 (en) 2023-05-05 2023-06-21 Tagomics Ltd Profiling method
WO2025104430A1 (en) 2023-11-14 2025-05-22 Tagomics Ltd Profiling method for determining epigenetic modifications
GB2644427A (en) 2024-07-23 2026-04-15 Tagomics Ltd Profiling method

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86724A (en) 1987-06-19 1995-01-24 Siska Diagnostics Inc Methods and kits for amplification and testing of nucleic acid sequences
AU631545B2 (en) 1988-04-15 1992-12-03 Protein Design Labs, Inc. Il-2 receptor-specific chimeric antibodies
JP2001081035A (ja) * 1999-09-10 2001-03-27 Kyowa Hakko Kogyo Co Ltd 降圧剤
US20070264667A1 (en) * 2003-09-03 2007-11-15 Robert Gellibolian Method and system for assaying transferase activity
EP1712557A1 (de) 2005-04-14 2006-10-18 RWTH Aachen S-Adenosyl-L-Methionine Analoge mit verlängerten aktivierten Gruppen zur Übertragung mit Methyltransferasen

Also Published As

Publication number Publication date
JP2008539166A (ja) 2008-11-13
WO2006108678A3 (en) 2007-01-18
JP5129120B2 (ja) 2013-01-23
EP1874790B1 (de) 2010-08-18
DE602006016259D1 (de) 2010-09-30
US20090018101A1 (en) 2009-01-15
WO2006108678A2 (en) 2006-10-19
US8008007B2 (en) 2011-08-30
EP1874790A2 (de) 2008-01-09
EP1712557A1 (de) 2006-10-18

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