ATE459724T1 - EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGEN - Google Patents

EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGEN

Info

Publication number
ATE459724T1
ATE459724T1 AT00946853T AT00946853T ATE459724T1 AT E459724 T1 ATE459724 T1 AT E459724T1 AT 00946853 T AT00946853 T AT 00946853T AT 00946853 T AT00946853 T AT 00946853T AT E459724 T1 ATE459724 T1 AT E459724T1
Authority
AT
Austria
Prior art keywords
library
protein
pairs
selection
versus
Prior art date
Application number
AT00946853T
Other languages
English (en)
Inventor
Stephen W Michnick
Joelle Pelletier
Andreas Pluckthun
Katja M Arndt
Original Assignee
Odyssey Thera Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Odyssey Thera Inc filed Critical Odyssey Thera Inc
Priority claimed from US09/603,885 external-priority patent/US6897017B1/en
Application granted granted Critical
Publication of ATE459724T1 publication Critical patent/ATE459724T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT00946853T 1999-06-26 2000-06-26 EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGEN ATE459724T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14121099P 1999-06-26 1999-06-26
PCT/US2000/017436 WO2001000866A1 (en) 1999-06-26 2000-06-26 An in vivo library-versus-library selection of optimized protein-protein interactions
US09/603,885 US6897017B1 (en) 1997-01-31 2000-06-26 Vivo library-versus-library selection of optimized protein-protein interactions

Publications (1)

Publication Number Publication Date
ATE459724T1 true ATE459724T1 (de) 2010-03-15

Family

ID=22494676

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00946853T ATE459724T1 (de) 1999-06-26 2000-06-26 EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGEN

Country Status (7)

Country Link
EP (1) EP1198586B1 (de)
JP (1) JP2003503067A (de)
AT (1) ATE459724T1 (de)
AU (1) AU6054900A (de)
CA (1) CA2377573A1 (de)
DE (1) DE60043937D1 (de)
WO (1) WO2001000866A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001137A1 (en) 1999-06-30 2001-01-04 Children's Medical Center Corporation Fusion protein and uses thereof
CA2384561A1 (en) 2000-05-12 2001-11-22 Yale University Methods of detecting interactions between proteins, peptides or libraries thereof using fusion proteins
JP2004501379A (ja) * 2000-06-23 2004-01-15 ドマンティス　リミテッド マトリクススクリーニング方法
US20020115068A1 (en) * 2000-06-23 2002-08-22 Ian Tomlinson Matrix screening method
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
KR101150334B1 (ko) * 2011-02-08 2012-06-08 엘에스산전 주식회사 진공차단기의 플렉서블 션트

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508511A (ja) 1990-07-10 1994-09-29 ケンブリッジ　アンティボディー　テクノロジー　リミティド 特異的な結合ペアーの構成員の製造方法
EP1405911A1 (de) * 1994-07-20 2004-04-07 The General Hospital Corporation System zur Erkennung von Protein-Interaktionen
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
GB9712818D0 (en) * 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US5925523A (en) * 1996-08-23 1999-07-20 President & Fellows Of Harvard College Intraction trap assay, reagents and uses thereof
CA2196496A1 (en) 1997-01-31 1998-07-31 Stephen William Watson Michnick Protein fragment complementation assay for the detection of protein-protein interactions
CA2345392A1 (en) * 1998-09-24 2000-03-30 Duke University Method of measuring protein-protein interactions in living cells
CA2377513A1 (en) * 1999-06-25 2001-01-04 Universitat Zurich Hetero-associating coiled-coil peptides

Also Published As

Publication number Publication date
JP2003503067A (ja) 2003-01-28
WO2001000866A1 (en) 2001-01-04
DE60043937D1 (de) 2010-04-15
EP1198586A4 (de) 2004-03-24
AU6054900A (en) 2001-01-31
EP1198586B1 (de) 2010-03-03
CA2377573A1 (en) 2001-01-04
EP1198586A1 (de) 2002-04-24

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