ATE459724T1 - EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGEN - Google Patents
EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGENInfo
- Publication number
- ATE459724T1 ATE459724T1 AT00946853T AT00946853T ATE459724T1 AT E459724 T1 ATE459724 T1 AT E459724T1 AT 00946853 T AT00946853 T AT 00946853T AT 00946853 T AT00946853 T AT 00946853T AT E459724 T1 ATE459724 T1 AT E459724T1
- Authority
- AT
- Austria
- Prior art keywords
- library
- protein
- pairs
- selection
- versus
- Prior art date
Links
- 230000003993 interaction Effects 0.000 title abstract 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 3
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 230000001580 bacterial effect Effects 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
- 241001529936 Murinae Species 0.000 abstract 1
- 108010022394 Threonine synthase Proteins 0.000 abstract 1
- 230000002860 competitive effect Effects 0.000 abstract 1
- 102000004419 dihydrofolate reductase Human genes 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 238000005734 heterodimerization reaction Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000009630 liquid culture Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000004850 protein–protein interaction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1055—Protein x Protein interaction, e.g. two hybrid selection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14121099P | 1999-06-26 | 1999-06-26 | |
| US09/603,885 US6897017B1 (en) | 1997-01-31 | 2000-06-26 | Vivo library-versus-library selection of optimized protein-protein interactions |
| PCT/US2000/017436 WO2001000866A1 (en) | 1999-06-26 | 2000-06-26 | An in vivo library-versus-library selection of optimized protein-protein interactions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE459724T1 true ATE459724T1 (de) | 2010-03-15 |
Family
ID=22494676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00946853T ATE459724T1 (de) | 1999-06-26 | 2000-06-26 | EINE IN VIVO ßBIBLIOTHEK-GEGEN-BIBLIOTHEK- SELEKTIONß VON OPTIMIERTEN PROTEIN-PROTEIN- WECHSELWIRKUNGEN |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1198586B1 (de) |
| JP (1) | JP2003503067A (de) |
| AT (1) | ATE459724T1 (de) |
| AU (1) | AU6054900A (de) |
| CA (1) | CA2377573A1 (de) |
| DE (1) | DE60043937D1 (de) |
| WO (1) | WO2001000866A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001001137A1 (en) | 1999-06-30 | 2001-01-04 | Children's Medical Center Corporation | Fusion protein and uses thereof |
| WO2001087919A2 (en) | 2000-05-12 | 2001-11-22 | Yale University | Methods of detecting interactions between proteins, peptides or libraries thereof using fusion proteins |
| US20020115068A1 (en) * | 2000-06-23 | 2002-08-22 | Ian Tomlinson | Matrix screening method |
| JP2004501379A (ja) * | 2000-06-23 | 2004-01-15 | ドマンティス リミテッド | マトリクススクリーニング方法 |
| US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
| KR101150334B1 (ko) * | 2011-02-08 | 2012-06-08 | 엘에스산전 주식회사 | 진공차단기의 플렉서블 션트 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0585287T3 (da) | 1990-07-10 | 2000-04-17 | Cambridge Antibody Tech | Fremgangsmåde til fremstilling af specifikke bindingsparelementer |
| DE69532127T2 (de) * | 1994-07-20 | 2004-08-26 | Genetics Institute, Inc., Cambridge | Interaktions-fullensysteme zum nachweis von protein-interaktionen |
| US5610015A (en) * | 1995-03-23 | 1997-03-11 | Wisconsin Alumni Research Foundation | System to detect protein-RNA interactions |
| GB9712818D0 (en) * | 1996-07-08 | 1997-08-20 | Cambridge Antibody Tech | Labelling and selection of specific binding molecules |
| US5925523A (en) * | 1996-08-23 | 1999-07-20 | President & Fellows Of Harvard College | Intraction trap assay, reagents and uses thereof |
| CA2196496A1 (en) * | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| EP1115734A4 (de) * | 1998-09-24 | 2004-07-21 | Univ Duke | Methoden zur messung von protein-protein wechselwirkungen in lebenden zellen |
| CA2377513A1 (en) * | 1999-06-25 | 2001-01-04 | Universitat Zurich | Hetero-associating coiled-coil peptides |
-
2000
- 2000-06-26 WO PCT/US2000/017436 patent/WO2001000866A1/en not_active Ceased
- 2000-06-26 DE DE60043937T patent/DE60043937D1/de not_active Expired - Fee Related
- 2000-06-26 CA CA002377573A patent/CA2377573A1/en not_active Abandoned
- 2000-06-26 AU AU60549/00A patent/AU6054900A/en not_active Abandoned
- 2000-06-26 AT AT00946853T patent/ATE459724T1/de not_active IP Right Cessation
- 2000-06-26 JP JP2001506857A patent/JP2003503067A/ja active Pending
- 2000-06-26 EP EP00946853A patent/EP1198586B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2377573A1 (en) | 2001-01-04 |
| EP1198586A1 (de) | 2002-04-24 |
| DE60043937D1 (de) | 2010-04-15 |
| WO2001000866A1 (en) | 2001-01-04 |
| EP1198586B1 (de) | 2010-03-03 |
| EP1198586A4 (de) | 2004-03-24 |
| AU6054900A (en) | 2001-01-31 |
| JP2003503067A (ja) | 2003-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |