ATE454402T1 - Kontrolle der verfügbarkeit oder aktivität der proteine durch verwendung von protease- inhibitoren oder rezeptor-fragmenten - Google Patents
Kontrolle der verfügbarkeit oder aktivität der proteine durch verwendung von protease- inhibitoren oder rezeptor-fragmentenInfo
- Publication number
- ATE454402T1 ATE454402T1 AT99910860T AT99910860T ATE454402T1 AT E454402 T1 ATE454402 T1 AT E454402T1 AT 99910860 T AT99910860 T AT 99910860T AT 99910860 T AT99910860 T AT 99910860T AT E454402 T1 ATE454402 T1 AT E454402T1
- Authority
- AT
- Austria
- Prior art keywords
- activity
- receptor
- availability
- proteins
- controlling
- Prior art date
Links
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 4
- 108010001857 Cell Surface Receptors Proteins 0.000 abstract 2
- 230000003828 downregulation Effects 0.000 abstract 2
- 230000003054 hormonal effect Effects 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 102000006240 membrane receptors Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 abstract 1
- 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 abstract 1
- 102000044159 Ubiquitin Human genes 0.000 abstract 1
- 108090000848 Ubiquitin Proteins 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000012202 endocytosis Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98200799A EP0943624A1 (de) | 1998-03-12 | 1998-03-12 | Peptidische Inhibitoren der Verminderungsregulation des Wachstumhormone-Rezeptors |
| PCT/NL1999/000136 WO1999046298A2 (en) | 1998-03-12 | 1999-03-12 | Controlling availability or activity of proteins by use of protease inhibitors or receptor fragments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE454402T1 true ATE454402T1 (de) | 2010-01-15 |
Family
ID=8233462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99910860T ATE454402T1 (de) | 1998-03-12 | 1999-03-12 | Kontrolle der verfügbarkeit oder aktivität der proteine durch verwendung von protease- inhibitoren oder rezeptor-fragmenten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6855546B1 (de) |
| EP (2) | EP0943624A1 (de) |
| AT (1) | ATE454402T1 (de) |
| AU (1) | AU768248B2 (de) |
| CA (1) | CA2323785C (de) |
| DE (1) | DE69941896D1 (de) |
| WO (1) | WO1999046298A2 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0943624A1 (de) * | 1998-03-12 | 1999-09-22 | Universiteit Utrecht | Peptidische Inhibitoren der Verminderungsregulation des Wachstumhormone-Rezeptors |
| AU4281199A (en) * | 1998-06-13 | 2000-01-05 | Zarpex Biosciences Limited | Proteasomal activity |
| DE10016083A1 (de) * | 2000-03-31 | 2001-10-18 | Ingenium Pharmaceuticals Ag | Nicht-menschliches Tiermodell für Wachstumsdefizienz und Defekte der Informationsverarbeitung oder der kognitiven Funktion und seine Verwendung |
| WO2006023211A2 (en) * | 2004-07-29 | 2006-03-02 | Albert Einstein College Of Medicine Of Yeshiva University | Antigens targeted by pathogenic ai4 t cells in type 1 diabetes and uses thereof |
| EP1749837A1 (de) * | 2005-08-02 | 2007-02-07 | Recharge B.V. | Methoden und Mittel zur Kontrolle von Endozytose und nachfolgendem Abbau eines Zelloberflächen-Proteins |
| US8034786B2 (en) | 2005-08-02 | 2011-10-11 | Recharge B.V. | Methods and means for controlling the endocytosis and subsequent degradation of growth hormone receptor |
| US20100240581A1 (en) * | 2006-11-13 | 2010-09-23 | The Trustees Of Columbia University In The City Of New York | Selective proteasome inhibitors for treating diabetes |
| US8389482B2 (en) * | 2007-01-30 | 2013-03-05 | New York University | Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species |
| US11320422B2 (en) * | 2016-01-06 | 2022-05-03 | Lonza Ltd. | Inhibition of protein degradation for improved production |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL112759A0 (en) * | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
| US6335358B1 (en) * | 1995-04-12 | 2002-01-01 | President And Fellows Of Harvard College | Lactacystin analogs |
| EP0943624A1 (de) * | 1998-03-12 | 1999-09-22 | Universiteit Utrecht | Peptidische Inhibitoren der Verminderungsregulation des Wachstumhormone-Rezeptors |
-
1998
- 1998-03-12 EP EP98200799A patent/EP0943624A1/de not_active Withdrawn
-
1999
- 1999-03-12 AT AT99910860T patent/ATE454402T1/de not_active IP Right Cessation
- 1999-03-12 EP EP99910860A patent/EP1062243B1/de not_active Expired - Lifetime
- 1999-03-12 DE DE69941896T patent/DE69941896D1/de not_active Expired - Lifetime
- 1999-03-12 CA CA2323785A patent/CA2323785C/en not_active Expired - Fee Related
- 1999-03-12 AU AU29627/99A patent/AU768248B2/en not_active Ceased
- 1999-03-12 WO PCT/NL1999/000136 patent/WO1999046298A2/en not_active Ceased
-
2000
- 2000-09-12 US US09/660,302 patent/US6855546B1/en not_active Expired - Fee Related
-
2005
- 2005-02-14 US US11/057,708 patent/US20050250702A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2323785A1 (en) | 1999-09-16 |
| WO1999046298A2 (en) | 1999-09-16 |
| WO1999046298A3 (en) | 1999-10-21 |
| DE69941896D1 (de) | 2010-02-25 |
| US6855546B1 (en) | 2005-02-15 |
| EP1062243B1 (de) | 2010-01-06 |
| AU768248B2 (en) | 2003-12-04 |
| EP0943624A1 (de) | 1999-09-22 |
| CA2323785C (en) | 2012-06-26 |
| US20050250702A1 (en) | 2005-11-10 |
| AU2962799A (en) | 1999-09-27 |
| EP1062243A2 (de) | 2000-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |