ATE451913T1 - SUBCUTANEOUS IMPLANTS THAT RELEASE AN ACTIVE SUBSTANCE OVER A LONGER PERIOD - Google Patents
SUBCUTANEOUS IMPLANTS THAT RELEASE AN ACTIVE SUBSTANCE OVER A LONGER PERIODInfo
- Publication number
- ATE451913T1 ATE451913T1 AT07788137T AT07788137T ATE451913T1 AT E451913 T1 ATE451913 T1 AT E451913T1 AT 07788137 T AT07788137 T AT 07788137T AT 07788137 T AT07788137 T AT 07788137T AT E451913 T1 ATE451913 T1 AT E451913T1
- Authority
- AT
- Austria
- Prior art keywords
- release
- subcutaneous implants
- active substance
- longer period
- substance over
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
Abstract
Subcutaneous implants obtained by extrusion containing (1) microparticles 5 containing an active ingredient dispersed in a PLGA matrix, and optionally microparticles (2) consisting of the same active ingredient or (2') of a different active ingredient preferably belonging to the same category as that contained in (1) all said microparticles (1) being dispersed in a matrix of PLGA (3), having a glass transition temperature lower than that of the PLGA contained in (1).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT001545A ITMI20061545A1 (en) | 2006-08-02 | 2006-08-02 | PARTICLES ABLE TO RELEASE THE ACTIVE PRINCIPLE FOR A PROLONGED PERIOD OF TIME |
PCT/EP2007/057969 WO2008015238A2 (en) | 2006-08-02 | 2007-08-01 | Subcutaneous implants releasing an active principle over an extended period of time |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE451913T1 true ATE451913T1 (en) | 2010-01-15 |
Family
ID=37846057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07788137T ATE451913T1 (en) | 2006-08-02 | 2007-08-01 | SUBCUTANEOUS IMPLANTS THAT RELEASE AN ACTIVE SUBSTANCE OVER A LONGER PERIOD |
Country Status (18)
Country | Link |
---|---|
US (1) | US20100003298A1 (en) |
EP (1) | EP2054037B1 (en) |
JP (1) | JP2009545564A (en) |
KR (1) | KR20090037946A (en) |
CN (1) | CN101553212A (en) |
AT (1) | ATE451913T1 (en) |
AU (1) | AU2007280397A1 (en) |
BR (1) | BRPI0714515A2 (en) |
CA (1) | CA2659441A1 (en) |
DE (1) | DE602007003854D1 (en) |
EA (1) | EA017292B1 (en) |
ES (1) | ES2337419T3 (en) |
HK (1) | HK1129835A1 (en) |
IT (1) | ITMI20061545A1 (en) |
MX (1) | MX2009001232A (en) |
PL (1) | PL2054037T3 (en) |
PT (1) | PT2054037E (en) |
WO (1) | WO2008015238A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010010016A (en) * | 2008-03-20 | 2010-09-30 | Organon Nv | Preparation of a pharmaceutical composition for increasing bone mineral density. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1311686C (en) * | 1986-06-25 | 1992-12-22 | John Weldon Shell | Controlled release bioerodible drug delivery system |
US5490962A (en) * | 1993-10-18 | 1996-02-13 | Massachusetts Institute Of Technology | Preparation of medical devices by solid free-form fabrication methods |
US5942253A (en) * | 1995-10-12 | 1999-08-24 | Immunex Corporation | Prolonged release of GM-CSF |
US5817343A (en) * | 1996-05-14 | 1998-10-06 | Alkermes, Inc. | Method for fabricating polymer-based controlled-release devices |
IT1304152B1 (en) * | 1998-12-10 | 2001-03-08 | Mediolanum Farmaceutici Srl | COMPOSITIONS INCLUDING A PEPTIDE AND POLYLACTIC-GLYCOLIC ACID FOR THE PREPARATION OF SUBCUTANEOUS IMPLANTS HAVING A PROLONGED |
ES2291893T3 (en) * | 2003-06-26 | 2008-03-01 | Mediolanum Pharmaceuticals Limited | SUBCUTANEOUS IMPLANTS WITH LIMITED INITIAL RELEASE OF THE ACTIVE AND SUBSEQUENT PRINCIPLE LINEARLY VARIABLE LONG RELEASE OF THE SAME. |
WO2005084710A2 (en) * | 2004-03-02 | 2005-09-15 | Massachusetts Institute Of Technology | Nanocell drug delivery system |
-
2006
- 2006-08-02 IT IT001545A patent/ITMI20061545A1/en unknown
-
2007
- 2007-08-01 CA CA002659441A patent/CA2659441A1/en not_active Abandoned
- 2007-08-01 PL PL07788137T patent/PL2054037T3/en unknown
- 2007-08-01 WO PCT/EP2007/057969 patent/WO2008015238A2/en active Application Filing
- 2007-08-01 PT PT07788137T patent/PT2054037E/en unknown
- 2007-08-01 MX MX2009001232A patent/MX2009001232A/en active IP Right Grant
- 2007-08-01 CN CNA2007800365047A patent/CN101553212A/en active Pending
- 2007-08-01 JP JP2009522274A patent/JP2009545564A/en active Pending
- 2007-08-01 BR BRPI0714515-2A patent/BRPI0714515A2/en not_active IP Right Cessation
- 2007-08-01 KR KR1020097003183A patent/KR20090037946A/en not_active Application Discontinuation
- 2007-08-01 ES ES07788137T patent/ES2337419T3/en active Active
- 2007-08-01 AU AU2007280397A patent/AU2007280397A1/en not_active Abandoned
- 2007-08-01 AT AT07788137T patent/ATE451913T1/en active
- 2007-08-01 EP EP07788137A patent/EP2054037B1/en not_active Not-in-force
- 2007-08-01 DE DE602007003854T patent/DE602007003854D1/en active Active
- 2007-08-01 US US12/309,875 patent/US20100003298A1/en not_active Abandoned
- 2007-08-01 EA EA200900247A patent/EA017292B1/en not_active IP Right Cessation
-
2009
- 2009-08-05 HK HK09107201.1A patent/HK1129835A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2008015238A3 (en) | 2008-03-20 |
DE602007003854D1 (en) | 2010-01-28 |
JP2009545564A (en) | 2009-12-24 |
EP2054037B1 (en) | 2009-12-16 |
EA017292B1 (en) | 2012-11-30 |
EP2054037A2 (en) | 2009-05-06 |
PT2054037E (en) | 2010-03-24 |
US20100003298A1 (en) | 2010-01-07 |
ITMI20061545A1 (en) | 2008-02-03 |
AU2007280397A1 (en) | 2008-02-07 |
WO2008015238A2 (en) | 2008-02-07 |
HK1129835A1 (en) | 2009-12-11 |
PL2054037T3 (en) | 2010-05-31 |
WO2008015238A8 (en) | 2008-06-05 |
KR20090037946A (en) | 2009-04-16 |
MX2009001232A (en) | 2009-04-28 |
CN101553212A (en) | 2009-10-07 |
ES2337419T3 (en) | 2010-04-23 |
CA2659441A1 (en) | 2008-02-07 |
EA200900247A1 (en) | 2009-06-30 |
BRPI0714515A2 (en) | 2013-04-24 |
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