ATE442169T1 - Lokale, vaskuläre verabreichung von cladribin in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen - Google Patents
Lokale, vaskuläre verabreichung von cladribin in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungenInfo
- Publication number
- ATE442169T1 ATE442169T1 AT05250908T AT05250908T ATE442169T1 AT E442169 T1 ATE442169 T1 AT E442169T1 AT 05250908 T AT05250908 T AT 05250908T AT 05250908 T AT05250908 T AT 05250908T AT E442169 T1 ATE442169 T1 AT E442169T1
- Authority
- AT
- Austria
- Prior art keywords
- devices
- agents
- compounds
- medical device
- utilized
- Prior art date
Links
- PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 title 1
- 208000024248 Vascular System injury Diseases 0.000 title 1
- 208000012339 Vascular injury Diseases 0.000 title 1
- 229960002436 cladribine Drugs 0.000 title 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title 1
- 208000037803 restenosis Diseases 0.000 title 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
- 229960002930 sirolimus Drugs 0.000 title 1
- 230000002792 vascular Effects 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229940124597 therapeutic agent Drugs 0.000 abstract 4
- 229940126585 therapeutic drug Drugs 0.000 abstract 4
- 239000000560 biocompatible material Substances 0.000 abstract 2
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- 230000035876 healing Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Surgical Instruments (AREA)
- Prostheses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/780,596 US7806924B2 (en) | 2004-02-18 | 2004-02-18 | Implantable structures for local vascular delivery of cladribine in combination with rapamycin for restenosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE442169T1 true ATE442169T1 (de) | 2009-09-15 |
Family
ID=34750452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05250908T ATE442169T1 (de) | 2004-02-18 | 2005-02-17 | Lokale, vaskuläre verabreichung von cladribin in kombination mit rapamycin zur vorbeugung von restenose nach gefässverletzungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7806924B2 (enExample) |
| EP (1) | EP1570871B1 (enExample) |
| JP (1) | JP4846246B2 (enExample) |
| AT (1) | ATE442169T1 (enExample) |
| CA (1) | CA2497216C (enExample) |
| DE (1) | DE602005016479D1 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7611533B2 (en) | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| US7572245B2 (en) * | 2003-09-15 | 2009-08-11 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
| US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
| US7947015B2 (en) * | 1999-01-25 | 2011-05-24 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
| US8038708B2 (en) | 2001-02-05 | 2011-10-18 | Cook Medical Technologies Llc | Implantable device with remodelable material and covering material |
| US7056338B2 (en) | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
| DE60235775D1 (de) * | 2001-11-08 | 2010-05-06 | Ziscoat N V | Intraluminale Vorrichtung mit einer therapeutisches-mittel enthaltenden Beschichtung |
| WO2004087214A1 (en) | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device with beneficial agent concentration gradient |
| US8021331B2 (en) * | 2003-09-15 | 2011-09-20 | Atrium Medical Corporation | Method of coating a folded medical device |
| US20050113687A1 (en) * | 2003-09-15 | 2005-05-26 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using a porous medical device |
| US7244441B2 (en) * | 2003-09-25 | 2007-07-17 | Scios, Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| US20050249776A1 (en) * | 2003-12-19 | 2005-11-10 | Chen Chao C | Coated aneurysmal repair device |
| US8747881B2 (en) | 2003-12-19 | 2014-06-10 | Cordis Corporation | Intraluminal medical devices in combination with therapeutic agents |
| US8652502B2 (en) | 2003-12-19 | 2014-02-18 | Cordis Corporation | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
| EP2594259A1 (en) | 2004-08-04 | 2013-05-22 | Brookwood Pharmaceuticals, Inc. | Methods for manufacturing delivery devices and devices thereof |
| US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US8312836B2 (en) | 2004-09-28 | 2012-11-20 | Atrium Medical Corporation | Method and apparatus for application of a fresh coating on a medical device |
| WO2006036983A2 (en) | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Pre-dried drug delivery coating for use with a stent |
| US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US9801982B2 (en) | 2004-09-28 | 2017-10-31 | Atrium Medical Corporation | Implantable barrier device |
| WO2006036970A2 (en) * | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Method of thickening a coating using a drug |
| US8367099B2 (en) | 2004-09-28 | 2013-02-05 | Atrium Medical Corporation | Perforated fatty acid films |
| US8124127B2 (en) | 2005-10-15 | 2012-02-28 | Atrium Medical Corporation | Hydrophobic cross-linked gels for bioabsorbable drug carrier coatings |
| WO2006036964A2 (en) | 2004-09-28 | 2006-04-06 | Atrium Medical Corporation | Barrier layer |
| US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
| US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
| US8574627B2 (en) | 2006-11-06 | 2013-11-05 | Atrium Medical Corporation | Coated surgical mesh |
| US20070116736A1 (en) * | 2005-11-23 | 2007-05-24 | Argentieri Dennis C | Local vascular delivery of PI3 kinase inhibitors alone or in combination with sirolimus to prevent restinosis following vascular injury |
| US20070203564A1 (en) * | 2006-02-28 | 2007-08-30 | Boston Scientific Scimed, Inc. | Biodegradable implants having accelerated biodegradation properties in vivo |
| US9492596B2 (en) | 2006-11-06 | 2016-11-15 | Atrium Medical Corporation | Barrier layer with underlying medical device and one or more reinforcing support structures |
| US8142490B2 (en) | 2007-10-24 | 2012-03-27 | Cordis Corporation | Stent segments axially connected by thin film |
| US8728528B2 (en) | 2007-12-20 | 2014-05-20 | Evonik Corporation | Process for preparing microparticles having a low residual solvent volume |
| US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
| US20110301695A1 (en) * | 2010-06-08 | 2011-12-08 | Svelte Medical Systems, Inc. | Optimum coatings for vascular stents |
| EP2582408B1 (en) | 2010-06-21 | 2014-09-10 | Zorion Medical, Inc. | Bioabsorbable implants |
| WO2012009707A2 (en) | 2010-07-16 | 2012-01-19 | Atrium Medical Corporation | Composition and methods for altering the rate of hydrolysis of cured oil-based materials |
| WO2012075311A2 (en) | 2010-12-01 | 2012-06-07 | Zorion Medical, Inc. | Magnesium-based absorbable implants |
| US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
| EP2968730B1 (en) | 2013-03-15 | 2019-01-09 | Bitol Designs, LLC | Occlusion resistant catheter and method of use |
| CA2998170C (en) | 2015-09-15 | 2023-10-03 | Savage Medical, Inc. | Devices and methods for anchoring a sheath in a tissue cavity |
| JP7108631B2 (ja) | 2017-01-06 | 2022-07-28 | パルヴェラ セラピューティクス、インク. | mTOR阻害剤の無水組成物およびその使用方法 |
| CN107335100A (zh) * | 2017-07-31 | 2017-11-10 | 首都医科大学附属北京安贞医院 | 一种冠状动脉旁路移植术预防桥血管再狭窄系统 |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク. | mTOR阻害剤の無水組成物および使用方法 |
| WO2022271702A1 (en) * | 2021-06-21 | 2022-12-29 | Palvella Therapeutics, Inc. | Methods and compositions for treating gorlin syndrome |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
| US3959078A (en) * | 1973-05-18 | 1976-05-25 | Midwest Research Institute | Enzyme immobilization with a thermochemical-photochemical bifunctional agent |
| SU1088712A1 (ru) * | 1979-11-14 | 1984-04-30 | Всесоюзный научно-исследовательский и испытательный институт медицинской техники | Аппарат дл циркул рного сшивани кровеносных сосудов |
| US4368736A (en) | 1980-11-17 | 1983-01-18 | Kaster Robert L | Anastomotic fitting |
| US4366819A (en) * | 1980-11-17 | 1983-01-04 | Kaster Robert L | Anastomotic fitting |
| US4917091A (en) * | 1982-06-24 | 1990-04-17 | Unilink Ab | Annular fastening means |
| SE431609B (sv) | 1982-06-24 | 1984-02-20 | Unilink Ab | Kirurgiskt instrument for astadkommande av anastomos och festelement herfor |
| US4722906A (en) * | 1982-09-29 | 1988-02-02 | Bio-Metric Systems, Inc. | Binding reagents and methods |
| US4733665C2 (en) * | 1985-11-07 | 2002-01-29 | Expandable Grafts Partnership | Expandable intraluminal graft and method and apparatus for implanting an expandable intraluminal graft |
| US5234447A (en) * | 1990-08-28 | 1993-08-10 | Robert L. Kaster | Side-to-end vascular anastomotic staple apparatus |
| US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
| US5350800A (en) * | 1993-01-19 | 1994-09-27 | Medtronic, Inc. | Method for improving the biocompatibility of solid surfaces |
| US5308641A (en) * | 1993-01-19 | 1994-05-03 | Medtronic, Inc. | Biocompatibility of solid surfaces |
| US5229172A (en) * | 1993-01-19 | 1993-07-20 | Medtronic, Inc. | Modification of polymeric surface by graft polymerization |
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| US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6120536A (en) * | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
| WO1998033443A1 (en) | 1997-02-03 | 1998-08-06 | Angioguard, Inc. | Vascular filter |
| US6425898B1 (en) * | 1998-03-13 | 2002-07-30 | Cordis Corporation | Delivery apparatus for a self-expanding stent |
| US8029561B1 (en) | 2000-05-12 | 2011-10-04 | Cordis Corporation | Drug combination useful for prevention of restenosis |
| US6153252A (en) * | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
| CA2340652C (en) * | 1998-08-20 | 2013-09-24 | Cook Incorporated | Coated implantable medical device comprising paclitaxel |
| AU780539B2 (en) | 2000-02-25 | 2005-03-24 | Cordis Corporation | Use of cladribine on a stent to prevent restenosis |
| US7419678B2 (en) * | 2000-05-12 | 2008-09-02 | Cordis Corporation | Coated medical devices for the prevention and treatment of vascular disease |
| AU1129902A (en) * | 2000-09-29 | 2002-04-08 | Cordis Corp | Coated medical devices |
| US7195640B2 (en) * | 2001-09-25 | 2007-03-27 | Cordis Corporation | Coated medical devices for the treatment of vulnerable plaque |
| US8652502B2 (en) * | 2003-12-19 | 2014-02-18 | Cordis Corporation | Local vascular delivery of trichostatin A alone or in combination with sirolimus to prevent restenosis following vascular injury |
| US7306677B2 (en) * | 2004-01-30 | 2007-12-11 | Boston Scientific Corporation | Clamping fixture for coating stents, system using the fixture, and method of using the fixture |
-
2004
- 2004-02-18 US US10/780,596 patent/US7806924B2/en active Active
-
2005
- 2005-02-16 CA CA2497216A patent/CA2497216C/en not_active Expired - Lifetime
- 2005-02-17 JP JP2005040910A patent/JP4846246B2/ja not_active Expired - Fee Related
- 2005-02-17 AT AT05250908T patent/ATE442169T1/de not_active IP Right Cessation
- 2005-02-17 DE DE602005016479T patent/DE602005016479D1/de not_active Expired - Lifetime
- 2005-02-17 EP EP05250908A patent/EP1570871B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1570871A1 (en) | 2005-09-07 |
| US20050182485A1 (en) | 2005-08-18 |
| JP4846246B2 (ja) | 2011-12-28 |
| JP2005253959A (ja) | 2005-09-22 |
| EP1570871B1 (en) | 2009-09-09 |
| CA2497216A1 (en) | 2005-08-18 |
| US7806924B2 (en) | 2010-10-05 |
| CA2497216C (en) | 2014-01-07 |
| DE602005016479D1 (de) | 2009-10-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |