ATE427973T1 - Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffen - Google Patents

Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffen

Info

Publication number
ATE427973T1
ATE427973T1 AT05751092T AT05751092T ATE427973T1 AT E427973 T1 ATE427973 T1 AT E427973T1 AT 05751092 T AT05751092 T AT 05751092T AT 05751092 T AT05751092 T AT 05751092T AT E427973 T1 ATE427973 T1 AT E427973T1
Authority
AT
Austria
Prior art keywords
controlled way
polypeptides
catch
ability
active ingredients
Prior art date
Application number
AT05751092T
Other languages
English (en)
Inventor
Ernest Llede
Pau Poyatos
Frances Rabanal Anglada
Jose Pastor Porras
Oscar Pena Gulin
Original Assignee
Farmhispania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmhispania filed Critical Farmhispania
Application granted granted Critical
Publication of ATE427973T1 publication Critical patent/ATE427973T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
AT05751092T 2004-06-10 2005-06-09 Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffen ATE427973T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57892904P 2004-06-10 2004-06-10

Publications (1)

Publication Number Publication Date
ATE427973T1 true ATE427973T1 (de) 2009-04-15

Family

ID=35079310

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05751092T ATE427973T1 (de) 2004-06-10 2005-06-09 Polypeptide mit fahigkeit zum einfangen und kontrollierten freisetzen von wirkstoffen

Country Status (7)

Country Link
US (1) US20050276783A1 (de)
EP (1) EP1753803B1 (de)
AT (1) ATE427973T1 (de)
CA (1) CA2569672A1 (de)
DE (1) DE602005013773D1 (de)
ES (1) ES2325331T3 (de)
WO (1) WO2005121215A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070134335A1 (en) * 2005-06-08 2007-06-14 Lledo Ernest G Polypeptides with the capacity to entrap drugs and release them in a controlled way
CN101321806B (zh) 2005-12-05 2011-01-26 日东电工株式会社 聚谷氨酸盐-氨基酸轭合物及方法
CA2683590A1 (en) 2007-05-09 2008-11-20 Nitto Denko Corporation Compositions that include a hydrophobic compound and a polyamino acid conjugate
WO2009027998A2 (en) * 2007-08-27 2009-03-05 Natco Pharma Limited A process for the preparation of alanine-nca (alanine-n-carboxyanhydride) from alanine with tri phosgene
KR20110074583A (ko) * 2008-10-15 2011-06-30 닛토덴코 가부시키가이샤 폴리글루타메이트 접합체의 제조 방법
CA2782410A1 (en) * 2009-12-16 2011-06-23 Nitto Denko Corporation Controlled synthesis of polyglutamic acid
EP2942348B1 (de) * 2014-05-07 2017-10-25 Johannes Gutenberg-Universität Mainz Thiol-geschützte Aminosäurederivate und ihre Verwendungen

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3529625A1 (de) * 1985-03-01 1986-09-04 Consortium für elektrochemische Industrie GmbH, 8000 München Phytochelatine, verfahren zu deren herstellung und ihre verwendung
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
EP1065233A1 (de) * 1998-02-27 2001-01-03 Ono Pharmaceutical Co., Ltd. Trägerpolymere, die in zielorgane wandern sowie arzneistoffhaltige polymere
US7018654B2 (en) * 1999-03-05 2006-03-28 New River Pharmaceuticals Inc. Pharmaceutical composition containing an active agent in an amino acid copolymer structure
EP1257592A1 (de) * 1999-03-05 2002-11-20 Innovative Technologies, LLC Verwendung der konformation von proteinen zum schutz und abgabe chemischer verbindungen
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
JP2001323059A (ja) * 2000-05-18 2001-11-20 Hisamitsu Pharmaceut Co Inc ポリペプチド誘導体および核酸運搬体
US20070134335A1 (en) * 2005-06-08 2007-06-14 Lledo Ernest G Polypeptides with the capacity to entrap drugs and release them in a controlled way

Also Published As

Publication number Publication date
CA2569672A1 (en) 2005-12-22
WO2005121215A2 (en) 2005-12-22
EP1753803B1 (de) 2009-04-08
WO2005121215A3 (en) 2006-08-10
ES2325331T3 (es) 2009-09-01
US20050276783A1 (en) 2005-12-15
DE602005013773D1 (de) 2009-05-20
EP1753803A2 (de) 2007-02-21

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