ATE424377T1 - Verfahren und gerät zur verwendung von ä11cü- kohlenstoffmonoxyd bei der synthese von markern durch photoinitiierte carbonylierung - Google Patents

Verfahren und gerät zur verwendung von ä11cü- kohlenstoffmonoxyd bei der synthese von markern durch photoinitiierte carbonylierung

Info

Publication number
ATE424377T1
ATE424377T1 AT04791743T AT04791743T ATE424377T1 AT E424377 T1 ATE424377 T1 AT E424377T1 AT 04791743 T AT04791743 T AT 04791743T AT 04791743 T AT04791743 T AT 04791743T AT E424377 T1 ATE424377 T1 AT E424377T1
Authority
AT
Austria
Prior art keywords
carbonylation
carbon monoxide
λ11cü
photoinitiated
markers
Prior art date
Application number
AT04791743T
Other languages
English (en)
Inventor
Tor Kihlberg
O Itsenko
Tommy Ferm
Bengt Langstrom
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Application granted granted Critical
Publication of ATE424377T1 publication Critical patent/ATE424377T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B32/00—Carbon; Compounds thereof
    • C01B32/40—Carbon monoxide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT04791743T 2003-10-31 2004-10-25 Verfahren und gerät zur verwendung von ä11cü- kohlenstoffmonoxyd bei der synthese von markern durch photoinitiierte carbonylierung ATE424377T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51652503P 2003-10-31 2003-10-31

Publications (1)

Publication Number Publication Date
ATE424377T1 true ATE424377T1 (de) 2009-03-15

Family

ID=34549545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04791743T ATE424377T1 (de) 2003-10-31 2004-10-25 Verfahren und gerät zur verwendung von ä11cü- kohlenstoffmonoxyd bei der synthese von markern durch photoinitiierte carbonylierung

Country Status (6)

Country Link
US (2) US7521544B2 (de)
EP (1) EP1678102B1 (de)
AT (1) ATE424377T1 (de)
DE (1) DE602004019800D1 (de)
ES (1) ES2320897T3 (de)
WO (1) WO2005042441A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1689675A2 (de) * 2003-12-03 2006-08-16 GE Healthcare Limited Verfahren und vorrichtung zur synthese von 11c|-phosgen unter verwendung von konzentriertem 11c|-kohlenmonoxid mit uv-licht
WO2006008603A1 (en) * 2004-07-09 2006-01-26 Ge Healthcare Limited Methods and apparatus for production and use of [11c] carbon monoxide in labeling synthesis
US20060171882A1 (en) * 2005-02-01 2006-08-03 Bengt Langstrom Method for the use of [11C] carbon monoxide in labeling synthesis of 11C-labelled compounds by thermally induced free radical carbonylation
US20060217537A1 (en) * 2005-03-22 2006-09-28 Bengt Langstrom Methods for carbon isotope labeling synthesis by transition metal-promoted carbonylation via ketene using diazo compounds and carbon-isotope monoxide
WO2006131803A2 (en) * 2005-06-08 2006-12-14 Ge Healthcare Limited Method for the use of [11c] carbon monoxide in labeling synthesis of 11c-labelled esters and acids by sensitized photo-induced free radical carbonylation
US8232424B2 (en) 2005-06-17 2012-07-31 Ge Healthcare Limited Method for the use of [11C]carbon monoxide in labeling synthesis of 11C-labelled acids by photo-induced free radical carbonylation under mild conditions using sulfoxides
EP1934160B1 (de) * 2005-08-31 2014-07-23 GE Healthcare Limited Verfahren zur verwendung von [11c] kohlenstoffmonoxid bei der markierenden synthese von 11c-markierten ketonen durch photoinduzierte radikalische carbonylierung
WO2007072182A2 (en) 2005-12-21 2007-06-28 Ge Healthcare Limited Miniaturized liquid surface reactions using nanomolar amounts of concentrated [11c]carbon dioxide in a stationary gas-phase
US9101895B2 (en) 2011-04-15 2015-08-11 General Electric Company System for mixing and dispersing microbubble pharmaceuticals

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303086B1 (en) * 1999-10-28 2001-10-16 Radiant Optics, Inc. Disinfecting water by means of ultraviolet light
SE0102174D0 (sv) * 2001-06-19 2001-06-19 Tor Kihlberg Method and apparatus for production and use of (11C) carbon monoxide in labeling synthesis

Also Published As

Publication number Publication date
WO2005042441A1 (en) 2005-05-12
US7521544B2 (en) 2009-04-21
US8282888B2 (en) 2012-10-09
DE602004019800D1 (de) 2009-04-16
EP1678102A1 (de) 2006-07-12
EP1678102B1 (de) 2009-03-04
US20090203909A1 (en) 2009-08-13
ES2320897T3 (es) 2009-05-29
US20070043213A1 (en) 2007-02-22

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