ATE419346T1 - Hemmung der bildung von atherosklerotischen wunden mittels afabp antisens nukleinsäuren - Google Patents
Hemmung der bildung von atherosklerotischen wunden mittels afabp antisens nukleinsäurenInfo
- Publication number
- ATE419346T1 ATE419346T1 AT00908604T AT00908604T ATE419346T1 AT E419346 T1 ATE419346 T1 AT E419346T1 AT 00908604 T AT00908604 T AT 00908604T AT 00908604 T AT00908604 T AT 00908604T AT E419346 T1 ATE419346 T1 AT E419346T1
- Authority
- AT
- Austria
- Prior art keywords
- afabp
- atherosclerotic
- formation
- wounds
- inhibition
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11988099P | 1999-02-12 | 1999-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE419346T1 true ATE419346T1 (de) | 2009-01-15 |
Family
ID=22386964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00908604T ATE419346T1 (de) | 1999-02-12 | 2000-02-11 | Hemmung der bildung von atherosklerotischen wunden mittels afabp antisens nukleinsäuren |
Country Status (8)
Country | Link |
---|---|
US (1) | US20090012020A1 (de) |
EP (1) | EP1151092B1 (de) |
JP (1) | JP2002536459A (de) |
AT (1) | ATE419346T1 (de) |
AU (1) | AU781295B2 (de) |
CA (1) | CA2361335A1 (de) |
DE (1) | DE60041246D1 (de) |
WO (1) | WO2000047734A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0932201A (ja) * | 1995-07-15 | 1997-02-04 | Hotta Carpet Kk | 土木建築積層体 |
US7056662B2 (en) | 2000-02-17 | 2006-06-06 | President And Fellows Of Harvard College | Method of diagnosing a risk of developing insulin resistance |
AU2002345932A1 (en) * | 2001-06-26 | 2003-03-03 | San Diego State University Foundation | Compositions and methods for treating atherosclerosis |
US7262017B2 (en) | 2001-09-14 | 2007-08-28 | Torrey Pines Institute For Molecular Studies | Diagnostic markers for ischemia |
CA2556221C (en) | 2004-03-22 | 2013-12-31 | Alan Marc Kleinfeld | Development and use of fluorescent probes of unbound analytes |
US20060257938A1 (en) * | 2005-05-10 | 2006-11-16 | Kleinfeld Alan M | Method of screening for drugs that block ligand binding to a lipid binding protein |
US9164109B2 (en) | 2006-10-27 | 2015-10-20 | Alan Kleinfeld | Use of probes for unbound metabolites |
EP2403605B1 (de) * | 2009-03-05 | 2015-05-06 | President and Fellows of Harvard College | Zusammensetzungen enthaltend aP2-spezifischer Antikörper oder deren Bindungsfragment zur Verwendung bei der Behandlung von Diabetes, Glukoseintoleranz oder Adipositas-induzierten Insulinresistenz |
AU2016254215A1 (en) | 2015-04-30 | 2017-10-26 | President And Fellows Of Harvard College | Anti-aP2 antibodies and antigen binding agents to treat metabolic disorders |
DK3416684T3 (da) * | 2016-02-17 | 2023-07-31 | Regeneron Pharma | Fremgangsmåder til behandling eller forebyggelse af atherosklerose ved administration af en hæmmer af ANGPTL3 |
AU2018279950A1 (en) | 2017-06-09 | 2020-01-30 | President And Fellows Of Harvard College | Method to identify compounds useful to treat dysregulated lipogenesis, diabetes, and related disorders |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9019841D0 (en) * | 1990-09-11 | 1990-10-24 | Smith Kline French Lab | Compounds |
WO1992006104A1 (en) * | 1990-09-28 | 1992-04-16 | The Dana-Farber Cancer Institute | Adipocyte-specific dna sequences and use for the production of transgenic animals exhibiting altered fat metabolism |
US5254576A (en) * | 1992-04-03 | 1993-10-19 | Bristol-Myers Squibb Company | Diphenyl-heterocyclic-oxazole as platelet aggregation inhibitors |
AU6894298A (en) * | 1997-04-08 | 1998-10-30 | Incyte Pharmaceuticals, Inc. | Human fatty acid binding protein |
EP1113801A4 (de) * | 1998-09-17 | 2002-10-02 | Bristol Myers Squibb Co | Verfahren zur behandlung von atherosclerosis mit einem ap2-hemmer oder kombination |
-
2000
- 2000-02-11 DE DE60041246T patent/DE60041246D1/de not_active Expired - Fee Related
- 2000-02-11 JP JP2000598632A patent/JP2002536459A/ja active Pending
- 2000-02-11 AU AU29913/00A patent/AU781295B2/en not_active Ceased
- 2000-02-11 EP EP00908604A patent/EP1151092B1/de not_active Expired - Lifetime
- 2000-02-11 WO PCT/US2000/003560 patent/WO2000047734A1/en active IP Right Grant
- 2000-02-11 AT AT00908604T patent/ATE419346T1/de not_active IP Right Cessation
- 2000-02-11 CA CA002361335A patent/CA2361335A1/en not_active Abandoned
-
2007
- 2007-06-04 US US11/810,344 patent/US20090012020A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2000047734A1 (en) | 2000-08-17 |
AU2991300A (en) | 2000-08-29 |
DE60041246D1 (de) | 2009-02-12 |
AU781295B2 (en) | 2005-05-12 |
US20090012020A1 (en) | 2009-01-08 |
EP1151092A1 (de) | 2001-11-07 |
JP2002536459A (ja) | 2002-10-29 |
EP1151092B1 (de) | 2008-12-31 |
CA2361335A1 (en) | 2000-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI971489A (fi) | Uusia bentsoksatsoleja | |
BR9806752A (pt) | Ftalazinonas. | |
ATE318267T1 (de) | Einige alkylendiamin-substituierte heterocyclen | |
ATE272398T1 (de) | Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz | |
WO2001081312A3 (en) | Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore | |
WO2001078711A3 (en) | Pde-v inhibitors for treatment of parkinson's disease | |
DE69920757D1 (de) | Immunsuppressive wirkungen von pteridinderivaten | |
ATE232873T1 (de) | Phosphonsaürederivate als ptp-1b-inhibitoren | |
NO20010718L (no) | Ny saltform av pantoprazol | |
ATE419346T1 (de) | Hemmung der bildung von atherosklerotischen wunden mittels afabp antisens nukleinsäuren | |
ATE293450T1 (de) | Verwendung von biphosphonsäuren zur behandlung von angiogenese | |
PE20011085A1 (es) | Compuestos isoxazolquinolin o imidazolquinolin como inhibidores de la proteina resistente a multifarmacos | |
DK1458393T3 (da) | Substituerede diketopiperaziner som oxytocinantagonister | |
NO20014241D0 (no) | C16-umettede FP-selektive prostaglandinanaloger | |
ATE372114T1 (de) | Verfahren zur erhöhung des testosteronspiegels | |
ES2147973T3 (es) | Estirenos alquilatados como profarmacos de inhibidores de cox-2. | |
ATE290384T1 (de) | Etherlysophospholipide zur behandlung von chronischen entzündlichen erkrankungen | |
EA200100930A1 (ru) | Способ лечения хозл | |
ECSP003590A (es) | Compuestos calcioliticos | |
SE0002739D0 (sv) | New use | |
DE69229436T2 (de) | Verwendung von somatostatinanalogen zur behandlung von melanomen | |
ATE315387T1 (de) | Verwendung von substituierten 6- dimethylaminomethyl-1-phenyl- cyclohexanverbindungen zur therapie der harninkontinenz | |
ITTO20000441A0 (it) | Composizione terapeutica per la cura della psoriasi. | |
EA200600115A1 (ru) | Производные 2-аминобензойной кислоты | |
DE60004996D1 (de) | Aminotetralin derivate zur therapie der kardiovaskulären erkrankungen |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |