ATE416166T1 - Novel polysubstituted 1,1- pyridinylaminocyclopropanamine derivatives, processes for their preparation and pharmaceutical composition containing them - Google Patents

Novel polysubstituted 1,1- pyridinylaminocyclopropanamine derivatives, processes for their preparation and pharmaceutical composition containing them

Info

Publication number
ATE416166T1
ATE416166T1 AT06291218T AT06291218T ATE416166T1 AT E416166 T1 ATE416166 T1 AT E416166T1 AT 06291218 T AT06291218 T AT 06291218T AT 06291218 T AT06291218 T AT 06291218T AT E416166 T1 ATE416166 T1 AT E416166T1
Authority
AT
Austria
Prior art keywords
pyridinylaminocyclopropanamine
derivatives
processes
preparation
pharmaceutical composition
Prior art date
Application number
AT06291218T
Other languages
English (en)
Inventor
Solo Goldstein
Claude Guillonneau
Yves Charton
Brian Lockhart
Pierre Lestage
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of ATE416166T1 publication Critical patent/ATE416166T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06291218T 2005-07-28 2006-07-27 Novel polysubstituted 1,1- pyridinylaminocyclopropanamine derivatives, processes for their preparation and pharmaceutical composition containing them ATE416166T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0508032A FR2889188B1 (fr) 2005-07-28 2005-07-28 Nouveaux composes 1,1-pyridinylaminocyclopropanamines polysubstitues, leur procede de preparation et les compositions phamaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ATE416166T1 true ATE416166T1 (de) 2008-12-15

Family

ID=36169157

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06291218T ATE416166T1 (de) 2005-07-28 2006-07-27 Novel polysubstituted 1,1- pyridinylaminocyclopropanamine derivatives, processes for their preparation and pharmaceutical composition containing them

Country Status (31)

Country Link
US (2) US7388022B2 (de)
EP (1) EP1757586B1 (de)
JP (1) JP2007031439A (de)
KR (1) KR100824831B1 (de)
CN (1) CN100448848C (de)
AR (1) AR055589A1 (de)
AT (1) ATE416166T1 (de)
AU (1) AU2006203237A1 (de)
BR (1) BRPI0603027A (de)
CA (1) CA2552831A1 (de)
CR (1) CR9679A (de)
DE (1) DE602006003956D1 (de)
DK (1) DK1757586T3 (de)
EA (1) EA011124B1 (de)
EC (1) ECSP088127A (de)
ES (1) ES2318700T3 (de)
FR (1) FR2889188B1 (de)
GE (1) GEP20084506B (de)
GT (1) GT200800005A (de)
HR (1) HRP20090090T3 (de)
MA (1) MA28425B1 (de)
MX (1) MXPA06008541A (de)
NO (1) NO20063462L (de)
NZ (1) NZ548746A (de)
PL (1) PL1757586T3 (de)
PT (1) PT1757586E (de)
SG (1) SG129412A1 (de)
SI (1) SI1757586T1 (de)
TN (1) TNSN08023A1 (de)
WO (1) WO2007012761A1 (de)
ZA (1) ZA200606276B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2896800B1 (fr) * 2006-01-30 2008-04-11 Servier Lab Nouveaux composes pyridinylaminoalkylene-et pyridinyloxyalkylene-cyclopropanamines polysubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
US10288289B2 (en) * 2014-12-12 2019-05-14 United Technologies Corporation Gas turbine engine diffuser-combustor assembly inner casing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2095350C1 (ru) * 1993-10-13 1997-11-10 Центр по химии лекарственных средств (ЦХЛС-ВНИХФИ) 3-(n,n-диметилкарбамоилокси)-2-этил-6-метилпиридина сукцинат, обладающий антигипоксической активностью
TW544448B (en) * 1997-07-11 2003-08-01 Novartis Ag Pyridine derivatives
WO1999021834A1 (en) * 1997-10-27 1999-05-06 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
WO2000075110A1 (en) * 1999-06-07 2000-12-14 Targacept, Inc. Pharmaceutical compositions and methods for use
JP2001261652A (ja) * 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物
US6448276B1 (en) * 2000-05-17 2002-09-10 Inspire Pharmaceuticals, Inc. Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists
FR2810664B1 (fr) * 2000-06-27 2004-12-24 Adir Nouveaux composes cyclopropaniques 1,1 et 1,2-dissubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
ZA200606276B (en) 2007-12-27
GEP20084506B (en) 2008-10-10
US7388022B2 (en) 2008-06-17
SI1757586T1 (sl) 2009-04-30
DE602006003956D1 (en) 2009-01-15
AU2006203237A1 (en) 2007-02-15
PL1757586T3 (pl) 2009-04-30
AR055589A1 (es) 2007-08-29
EA200601247A1 (ru) 2007-04-27
FR2889188B1 (fr) 2007-09-07
SG129412A1 (en) 2007-02-26
US20070027192A1 (en) 2007-02-01
US20080146621A1 (en) 2008-06-19
ECSP088127A (es) 2008-02-20
CA2552831A1 (fr) 2007-01-28
EP1757586A1 (de) 2007-02-28
TNSN08023A1 (en) 2009-07-14
JP2007031439A (ja) 2007-02-08
KR100824831B1 (ko) 2008-04-23
CN1903844A (zh) 2007-01-31
FR2889188A1 (fr) 2007-02-02
NO20063462L (no) 2007-01-29
ES2318700T3 (es) 2009-05-01
BRPI0603027A (pt) 2007-03-13
PT1757586E (pt) 2009-02-17
MXPA06008541A (es) 2007-01-29
DK1757586T3 (da) 2009-03-09
KR20070015012A (ko) 2007-02-01
NZ548746A (en) 2007-06-29
WO2007012761A1 (fr) 2007-02-01
MA28425B1 (fr) 2007-02-01
HRP20090090T3 (en) 2009-03-31
CR9679A (es) 2008-02-20
WO2007012761A8 (fr) 2007-12-21
HK1098146A1 (zh) 2007-07-13
EP1757586B1 (de) 2008-12-03
EA011124B1 (ru) 2008-12-30
CN100448848C (zh) 2009-01-07
GT200800005A (es) 2008-09-24

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