ATE410696T1 - Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis - Google Patents
Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basisInfo
- Publication number
- ATE410696T1 ATE410696T1 AT05759896T AT05759896T ATE410696T1 AT E410696 T1 ATE410696 T1 AT E410696T1 AT 05759896 T AT05759896 T AT 05759896T AT 05759896 T AT05759896 T AT 05759896T AT E410696 T1 ATE410696 T1 AT E410696T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- aggregation
- compound
- antiprion
- sift
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Information Retrieval, Db Structures And Fs Structures Therefor (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04012254 | 2004-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE410696T1 true ATE410696T1 (de) | 2008-10-15 |
Family
ID=35451505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05759896T ATE410696T1 (de) | 2004-05-24 | 2005-05-24 | Identizifierung von antiprionwirkstoffen mittels screening mit hohem durchsatz auf sift-basis |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100029773A1 (de) |
EP (1) | EP1751553B1 (de) |
AT (1) | ATE410696T1 (de) |
DE (1) | DE602005010241D1 (de) |
WO (1) | WO2005116640A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE523788T1 (de) | 2006-06-08 | 2011-09-15 | Fu Berlin | ASSAY ZUR DIAGNOSE VON ALZHEIMER BASIEREND AUF DER BESTIMMUNG DES VERHÄLTNISSES VON SEKRETASE-Aß-SPALTPRODUKTEN |
WO2009009768A2 (en) * | 2007-07-12 | 2009-01-15 | Acumen Pharmaceuticals, Inc. | METHODS OF INHIBITING THE FORMATION OF AMYLOID-β DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUDS |
US9006283B2 (en) | 2007-07-12 | 2015-04-14 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid β oligomers using non-peptidic compounds |
RU2461377C2 (ru) * | 2007-07-12 | 2012-09-20 | Эйкьюмен Фамэсьютиклз, Инк. | Способ улучшения когнитивной функции (варианты) |
US8962677B2 (en) | 2007-07-12 | 2015-02-24 | Acumen Pharmaceuticals, Inc. | Methods of restoring cognitive ability using non-peptidic compounds |
CA2692775C (en) * | 2007-07-12 | 2015-03-24 | Acumen Pharmaceuticals, Inc. | Methods of enhancing cognitive function using non-peptidic compounds |
CA2692773A1 (en) * | 2007-07-12 | 2009-01-15 | Acumen Pharmaceuticals, Inc. | Methods of modifying amyloid .beta. oligomers using non-peptidic compounds |
WO2009079566A2 (en) | 2007-12-18 | 2009-06-25 | Acumen Pharmaceuticals, Inc. | Novel addl receptor polypeptides, polynucleotides and host cells for recombinant production |
KR101366372B1 (ko) | 2012-01-30 | 2014-02-25 | 부산대학교 산학협력단 | 피부미백, 항산화 및 ppar 활성을 갖는 신규 화합물 및 이의 의학적 용도 |
GB201303507D0 (en) * | 2013-02-27 | 2013-04-10 | Hollfelder Florian | Assays |
WO2021225982A1 (en) * | 2020-05-04 | 2021-11-11 | Children's Hospital Medical Center | Sos1 allosteric site targeting |
US20220144758A1 (en) * | 2020-11-12 | 2022-05-12 | Oregon State University | Molecular probe for selective detection of copper (ii) ions |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6613942B1 (en) * | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO2001025192A1 (en) * | 1999-10-06 | 2001-04-12 | Melacure Therapeutics Ab | Guanidine derivatives and their use in the production of a medicament for blocking xanthine oxidase/dehydrogenase |
US20050136444A1 (en) * | 2003-09-25 | 2005-06-23 | Scully Audra L. | Treating neuropathic pain with neuropeptide FF receptor 2 agonists |
-
2005
- 2005-05-24 EP EP05759896A patent/EP1751553B1/de not_active Not-in-force
- 2005-05-24 DE DE602005010241T patent/DE602005010241D1/de active Active
- 2005-05-24 WO PCT/EP2005/005614 patent/WO2005116640A2/en active Application Filing
- 2005-05-24 US US11/597,672 patent/US20100029773A1/en not_active Abandoned
- 2005-05-24 AT AT05759896T patent/ATE410696T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2005116640A2 (en) | 2005-12-08 |
DE602005010241D1 (de) | 2008-11-20 |
WO2005116640A3 (en) | 2006-03-09 |
EP1751553A2 (de) | 2007-02-14 |
EP1751553B1 (de) | 2008-10-08 |
US20100029773A1 (en) | 2010-02-04 |
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Legal Events
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |