ATE402693T1 - Fab i und hemmung von apicomplexan-parasiten - Google Patents
Fab i und hemmung von apicomplexan-parasitenInfo
- Publication number
- ATE402693T1 ATE402693T1 AT01986546T AT01986546T ATE402693T1 AT E402693 T1 ATE402693 T1 AT E402693T1 AT 01986546 T AT01986546 T AT 01986546T AT 01986546 T AT01986546 T AT 01986546T AT E402693 T1 ATE402693 T1 AT E402693T1
- Authority
- AT
- Austria
- Prior art keywords
- fab
- inhibition
- apicomplexan
- apicomplexan parasites
- discovery
- Prior art date
Links
- 241000224482 Apicomplexa Species 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title 1
- 244000045947 parasite Species 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 101150017040 I gene Proteins 0.000 abstract 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000002611 lead compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 229960003500 triclosan Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
- C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
- C12Y103/01009—Enoyl-[acyl-carrier-protein] reductase (NADH) (1.3.1.9)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25777100P | 2000-12-21 | 2000-12-21 | |
| US26449901P | 2001-01-26 | 2001-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE402693T1 true ATE402693T1 (de) | 2008-08-15 |
Family
ID=26946196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01986546T ATE402693T1 (de) | 2000-12-21 | 2001-12-20 | Fab i und hemmung von apicomplexan-parasiten |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20040137446A1 (de) |
| EP (1) | EP1363654B1 (de) |
| AT (1) | ATE402693T1 (de) |
| AU (2) | AU2002237731B2 (de) |
| CA (1) | CA2432992A1 (de) |
| DE (1) | DE60135157D1 (de) |
| WO (1) | WO2002049576A2 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004016220A2 (en) * | 2002-08-15 | 2004-02-26 | Mcleod Rima L | Apicomplexan pathways, inhibitiors, and drug delivery |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6071518A (en) * | 1992-05-29 | 2000-06-06 | The Regents Of The University Of California | GP900 glycoprotein and fragments for treatment and detection/diagnosis of cryptosporidium |
| CO5370679A1 (es) * | 1999-06-01 | 2004-02-27 | Smithkline Beecham Corp | Inhibidores fab 1 |
| EP1137386B8 (de) * | 1999-06-23 | 2006-12-13 | Jawaharlal Nehru Centre For Advanced Scientific Research | Verwendung von triclosan als antimalariamittel |
-
2001
- 2001-12-20 AU AU2002237731A patent/AU2002237731B2/en not_active Ceased
- 2001-12-20 DE DE60135157T patent/DE60135157D1/de not_active Expired - Fee Related
- 2001-12-20 CA CA002432992A patent/CA2432992A1/en not_active Abandoned
- 2001-12-20 AT AT01986546T patent/ATE402693T1/de not_active IP Right Cessation
- 2001-12-20 WO PCT/US2001/049738 patent/WO2002049576A2/en active IP Right Grant
- 2001-12-20 AU AU3773102A patent/AU3773102A/xx active Pending
- 2001-12-20 EP EP01986546A patent/EP1363654B1/de not_active Expired - Lifetime
-
2003
- 2003-06-18 US US10/465,527 patent/US20040137446A1/en not_active Abandoned
-
2007
- 2007-11-05 US US11/998,988 patent/US20090156687A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002049576A3 (en) | 2002-09-12 |
| US20040137446A1 (en) | 2004-07-15 |
| CA2432992A1 (en) | 2002-06-27 |
| DE60135157D1 (de) | 2008-09-11 |
| AU2002237731B2 (en) | 2007-03-22 |
| EP1363654B1 (de) | 2008-07-30 |
| EP1363654A4 (de) | 2005-05-25 |
| AU3773102A (en) | 2002-07-01 |
| US20090156687A1 (en) | 2009-06-18 |
| EP1363654A2 (de) | 2003-11-26 |
| WO2002049576A9 (en) | 2003-04-24 |
| WO2002049576A2 (en) | 2002-06-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |