ATE401394T1 - Verbesserte dnase flüssige lösungen - Google Patents

Verbesserte dnase flüssige lösungen

Info

Publication number
ATE401394T1
ATE401394T1 AT95911123T AT95911123T ATE401394T1 AT E401394 T1 ATE401394 T1 AT E401394T1 AT 95911123 T AT95911123 T AT 95911123T AT 95911123 T AT95911123 T AT 95911123T AT E401394 T1 ATE401394 T1 AT E401394T1
Authority
AT
Austria
Prior art keywords
dnase
solutions
calcium ion
liquid solutions
thermal aggregation
Prior art date
Application number
AT95911123T
Other languages
English (en)
Inventor
Hak-Kim Chan
Igor Gonda
Steven Shire
Suzanne Weck
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE401394T1 publication Critical patent/ATE401394T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
    • C12Y301/21001—Deoxyribonuclease I (3.1.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Jellies, Jams, And Syrups (AREA)
AT95911123T 1994-03-04 1995-02-28 Verbesserte dnase flüssige lösungen ATE401394T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20650494A 1994-03-04 1994-03-04
US37752795A 1995-01-20 1995-01-20

Publications (1)

Publication Number Publication Date
ATE401394T1 true ATE401394T1 (de) 2008-08-15

Family

ID=26901408

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95911123T ATE401394T1 (de) 1994-03-04 1995-02-28 Verbesserte dnase flüssige lösungen

Country Status (7)

Country Link
US (2) US6383788B1 (de)
EP (1) EP0748377B1 (de)
JP (1) JP3009224B2 (de)
AT (1) ATE401394T1 (de)
CA (1) CA2184581C (de)
DE (1) DE69535787D1 (de)
WO (1) WO1995023854A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383788B1 (en) * 1994-03-04 2002-05-07 Genentech, Inc. Minimizing thermally induced aggregation of DNase in solution with calcium
CA2264885A1 (en) * 1996-09-04 1998-03-12 Nexell Therapeutics Inc. Compositions containing nucleases and chelators to enhance the recovery of cells during cell separating procedures
PT1324776E (pt) 2000-10-12 2009-12-23 Genentech Inc Formulações de proteína concentradas de viscosidade reduzida
US8703126B2 (en) 2000-10-12 2014-04-22 Genentech, Inc. Reduced-viscosity concentrated protein formulations
AU2010221156A1 (en) 2009-03-06 2011-09-22 Genentech, Inc. Antibody formulation
LT2603232T (lt) 2010-08-11 2020-01-27 Ironwood Pharmaceuticals, Inc. Stabilios linaklotido vaisto formos
EP3214172B1 (de) 2014-10-31 2019-02-13 JCR Pharmaceuticals CO., LTD. Verfahren zur herstellung rekombinanter menschlicher dnasei
AU2016204793B2 (en) 2015-01-04 2021-12-16 Protalix Ltd. Modified DNase and uses thereof
WO2017049205A2 (en) * 2015-09-18 2017-03-23 Amunix Operating Inc. Growth hormone formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3042587A (en) * 1960-11-29 1962-07-03 Merck & Co Inc Stabilized desoxyribonuclease preparation
CA1059937A (en) 1975-03-25 1979-08-07 Boen T. Khouw Isolation and purification of deoxyribonuclease
US4233405A (en) * 1979-10-10 1980-11-11 Rohm And Haas Company Process for spray drying enzymes
JP3162372B2 (ja) * 1988-12-23 2001-04-25 ジェネンテク，インコーポレイテッド ヒトｄｎアーゼ
US5279823A (en) * 1992-06-08 1994-01-18 Genentech, Inc. Purified forms of DNASE
US6383788B1 (en) * 1994-03-04 2002-05-07 Genentech, Inc. Minimizing thermally induced aggregation of DNase in solution with calcium
US5580856A (en) * 1994-07-15 1996-12-03 Prestrelski; Steven J. Formulation of a reconstituted protein, and method and kit for the production thereof

Also Published As

Publication number Publication date
US7018825B2 (en) 2006-03-28
DE69535787D1 (de) 2008-08-28
EP0748377A1 (de) 1996-12-18
US20030054532A1 (en) 2003-03-20
CA2184581C (en) 2005-02-22
WO1995023854A1 (en) 1995-09-08
US6383788B1 (en) 2002-05-07
JP3009224B2 (ja) 2000-02-14
EP0748377B1 (de) 2008-07-16
CA2184581A1 (en) 1995-09-08
JPH09503394A (ja) 1997-04-08

Similar Documents

Publication Publication Date Title
SE9503143D0 (sv) New preparation
AU2506388A (en) Azelastine-containing medicaments for application in the nose and/or at the eye
TR199801180T2 (xx) Aneljestik etkiye sahip yeni bile�ikler.
CA2059403A1 (en) Use of Carrageenans in Topical Ophthalmic Compositions
IT1246188B (it) Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute.
ATE234108T1 (de) Therapeutikum zur unterdrückung von schnarchgeräuschen
ATE401394T1 (de) Verbesserte dnase flüssige lösungen
EP0177342A3 (de) Orale Formulierungen therapeutischer Proteine
IE891118L (en) Topical preparation for treating otopathy
DE69733089D1 (de) Behandlung der osteoarthritis durch verabreichung von poly-n-acetyl-d-glucosamin
RU95101385A (ru) Продукты, содержащие g-csf и tnf связующие протеина
DK1032379T3 (da) Præparat med azelainsyre
BR9803233A (pt) Preparação de combinação farmacêutica de um inibidor do trocador de sódio/hidrogênio e um medicamento para o tratamento de doenças cardiovasculares.
TR199801184T2 (xx) Analjezik tesirli yeni bile�ikler.
CA2189705A1 (en) Use of flupirtine for the prophylaxis and therapy of diseases associated with an impairment of the haematopoetic cell system
RU98111152A (ru) Применение активного вещества флупиртина или его фармакологически приемлемых солей в качестве лекарственного средства для профилактики и лечения заболеваний, ассоциированных с повреждением клеточной системы гемопоэза
ATE126063T1 (de) Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen.
ATE233085T1 (de) Arzneimittel zur topischen anwendung
IE840977L (en) Pharmaceutical preparations
EG17992A (en) Preparation of a medicament for arthritis and theumatism
KR960003718A (ko) 말초신경병 및 중추신경변성병의 치료에 유용한 의약의 제조를 위한 이펜프로딜 및 그 부분입체이성질체의 이용
RU94045140A (ru) Фармацевтическая композиция для профилактики или лечения вирусных заболеваний, способ ее получения и применение антагониста брадикинина или его физиологически переносимой соли в качестве средства для профилактики или лечения вирусных заболеваний
DE60217302D1 (de) Erhaltung von körpereigenen proteinen
RU96109524A (ru) Композиция - лекарственная форма противоартрозного средства глюкозамина гидрохлорида для иньекций
RU2000105081A (ru) Применение препарата "эсвицин" для лечения ревматоидного артрита

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties