ATE394374T1 - Verfahren zur herstellung eines indolderivates - Google Patents
Verfahren zur herstellung eines indolderivatesInfo
- Publication number
- ATE394374T1 ATE394374T1 AT99938233T AT99938233T ATE394374T1 AT E394374 T1 ATE394374 T1 AT E394374T1 AT 99938233 T AT99938233 T AT 99938233T AT 99938233 T AT99938233 T AT 99938233T AT E394374 T1 ATE394374 T1 AT E394374T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- indole derivative
- indole
- carboxylate
- pkb
- Prior art date
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- JRNVZBWKYDBUCA-UHFFFAOYSA-N N-chlorosuccinimide Chemical compound ClN1C(=O)CCC1=O JRNVZBWKYDBUCA-UHFFFAOYSA-N 0.000 abstract 2
- 239000012973 diazabicyclooctane Substances 0.000 abstract 1
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
- SBXYTQUGWXISRE-UHFFFAOYSA-N methyl 3-chloroindole-3-carboxylate Chemical compound C1=CC=C2C(C(=O)OC)(Cl)C=NC2=C1 SBXYTQUGWXISRE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000269 nucleophilic effect Effects 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9815483.4A GB9815483D0 (en) | 1998-07-16 | 1998-07-16 | Pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE394374T1 true ATE394374T1 (de) | 2008-05-15 |
Family
ID=10835641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99938233T ATE394374T1 (de) | 1998-07-16 | 1999-07-13 | Verfahren zur herstellung eines indolderivates |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1097135B1 (https=) |
| JP (2) | JP3842555B2 (https=) |
| AT (1) | ATE394374T1 (https=) |
| CA (1) | CA2337248C (https=) |
| DE (1) | DE69938661D1 (https=) |
| ES (1) | ES2307339T3 (https=) |
| GB (1) | GB9815483D0 (https=) |
| WO (1) | WO2000003983A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020091271A1 (en) | 1998-07-16 | 2002-07-11 | Smithkline Beecham Plc | Process for the preparation of an indole derivative |
| GB0211230D0 (en) | 2002-05-16 | 2002-06-26 | Medinnova Sf | Treatment of heart failure |
| WO2020061045A1 (en) | 2018-09-18 | 2020-03-26 | Leidos, Inc. | Sensor array multiplexer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3911297B2 (ja) * | 1996-08-16 | 2007-05-09 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Ｎ―［（１―ｎブチル―４―ピペリジル）メチル］―３，４―ジヒドロ―２Ｈ―［１，３］オキサジノ［３，２―ａ］インドール―１０―カルボキシアミドおよび塩ならびに製造における中間体 |
-
1998
- 1998-07-16 GB GBGB9815483.4A patent/GB9815483D0/en not_active Ceased
-
1999
- 1999-07-13 JP JP2000560092A patent/JP3842555B2/ja not_active Expired - Fee Related
- 1999-07-13 DE DE69938661T patent/DE69938661D1/de not_active Expired - Lifetime
- 1999-07-13 EP EP99938233A patent/EP1097135B1/en not_active Expired - Lifetime
- 1999-07-13 AT AT99938233T patent/ATE394374T1/de not_active IP Right Cessation
- 1999-07-13 ES ES99938233T patent/ES2307339T3/es not_active Expired - Lifetime
- 1999-07-13 WO PCT/EP1999/004943 patent/WO2000003983A1/en not_active Ceased
- 1999-07-13 CA CA2337248A patent/CA2337248C/en not_active Expired - Fee Related
-
2006
- 2006-03-20 JP JP2006076859A patent/JP4511484B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3842555B2 (ja) | 2006-11-08 |
| CA2337248A1 (en) | 2000-01-27 |
| EP1097135A1 (en) | 2001-05-09 |
| WO2000003983A1 (en) | 2000-01-27 |
| CA2337248C (en) | 2011-04-19 |
| JP2006176539A (ja) | 2006-07-06 |
| EP1097135B1 (en) | 2008-05-07 |
| GB9815483D0 (en) | 1998-09-16 |
| DE69938661D1 (de) | 2008-06-19 |
| ES2307339T3 (es) | 2008-11-16 |
| JP2002520391A (ja) | 2002-07-09 |
| JP4511484B2 (ja) | 2010-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |