ATE384134T1 - Methode zur bestimmung der thiopurin methyltransferase aktivität - Google Patents

Methode zur bestimmung der thiopurin methyltransferase aktivität

Info

Publication number
ATE384134T1
ATE384134T1 AT01933444T AT01933444T ATE384134T1 AT E384134 T1 ATE384134 T1 AT E384134T1 AT 01933444 T AT01933444 T AT 01933444T AT 01933444 T AT01933444 T AT 01933444T AT E384134 T1 ATE384134 T1 AT E384134T1
Authority
AT
Austria
Prior art keywords
subject
thiopurine
proteinaceous material
methylated purine
acid
Prior art date
Application number
AT01933444T
Other languages
English (en)
Inventor
Paul Barstad
Original Assignee
Prometheus Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometheus Lab Inc filed Critical Prometheus Lab Inc
Application granted granted Critical
Publication of ATE384134T1 publication Critical patent/ATE384134T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/91005—Transferases (2.) transferring one-carbon groups (2.1)
    • G01N2333/91011—Methyltransferases (general) (2.1.1.)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT01933444T 2000-05-19 2001-05-16 Methode zur bestimmung der thiopurin methyltransferase aktivität ATE384134T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20569500P 2000-05-19 2000-05-19

Publications (1)

Publication Number Publication Date
ATE384134T1 true ATE384134T1 (de) 2008-02-15

Family

ID=22763262

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01933444T ATE384134T1 (de) 2000-05-19 2001-05-16 Methode zur bestimmung der thiopurin methyltransferase aktivität

Country Status (7)

Country Link
US (2) US6576438B2 (de)
EP (1) EP1285085B1 (de)
JP (1) JP4803942B2 (de)
AT (1) ATE384134T1 (de)
AU (1) AU2001259871A1 (de)
DE (1) DE60132447D1 (de)
WO (1) WO2001090308A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1285085B1 (de) * 2000-05-19 2008-01-16 Prometheus Laboratories, Inc. Methode zur bestimmung der thiopurin methyltransferase aktivität
US6946258B2 (en) * 2002-03-04 2005-09-20 Biologix Diagnostics, Llc Rapid, immunochemical process for measuring thiopurine methyltransferase
US8188067B2 (en) 2004-04-01 2012-05-29 Teva Pharmaceutical Industries Ltd. Formulations of 6-mercaptopurine
CA2560997A1 (en) * 2004-04-01 2005-10-27 Teva Pharmaceutical Industries Ltd. Delayed release formulations of 6-mercaptopurine
US7252841B2 (en) * 2004-05-20 2007-08-07 Skeletal Kinetics, Llc Rapid setting calcium phosphate cements
US20060216726A1 (en) * 2004-11-16 2006-09-28 Prometheus Laboratories Inc. Method for optimizing thiopurine efficacy and toxicity using mass spectrometry
US7452689B2 (en) * 2005-05-20 2008-11-18 Mayo Foundation For Medical Education And Research Method for rapid determination of thiopurine methyltransferase activity
WO2008028001A2 (en) * 2006-08-29 2008-03-06 Cryobiophysica, Inc. Multi-component, simultaneous, independent multi-gradient system for liquid chromatography
WO2009124396A1 (en) * 2008-04-10 2009-10-15 The University Of British Columbia Polymorphisms predictive of platinum-coordinating compound-induced ototoxicity
EP2110130A1 (de) * 2008-04-18 2009-10-21 Teva Pharmaceutical Industries Ltd. Pharmazeutische Verwendung von 6-Mercaptopurin
US8039794B2 (en) 2008-12-16 2011-10-18 Quest Diagnostics Investments Incorporated Mass spectrometry assay for thiopurine-S-methyl transferase activity and products generated thereby
DE102013011995A1 (de) * 2013-07-18 2015-01-22 Robert Bosch Gesellschaft Für Medizinische Forschung Mbh Diagnostisches in-vitro-Verfahren
US20170105996A1 (en) 2015-10-16 2017-04-20 Teva Pharmaceutical Industries, Ltd. Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine
US20210001333A1 (en) 2019-07-03 2021-01-07 King Abdulaziz University Microfluidic device for measuring the enzymatic activity of thiopurin s-methyltransferase

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1285085B1 (de) * 2000-05-19 2008-01-16 Prometheus Laboratories, Inc. Methode zur bestimmung der thiopurin methyltransferase aktivität

Also Published As

Publication number Publication date
EP1285085A4 (de) 2004-11-24
US20030199015A1 (en) 2003-10-23
EP1285085A2 (de) 2003-02-26
DE60132447D1 (de) 2008-03-06
JP4803942B2 (ja) 2011-10-26
US6576438B2 (en) 2003-06-10
EP1285085B1 (de) 2008-01-16
US7138250B2 (en) 2006-11-21
WO2001090308A8 (en) 2003-10-30
WO2001090308A3 (en) 2002-08-15
JP2003534002A (ja) 2003-11-18
AU2001259871A1 (en) 2001-12-03
WO2001090308A2 (en) 2001-11-29
US20020028476A1 (en) 2002-03-07

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