ATE382058T1 - G-protein-gekoppelte rezeptor-antagonisten - Google Patents

G-protein-gekoppelte rezeptor-antagonisten

Info

Publication number
ATE382058T1
ATE382058T1 AT99908589T AT99908589T ATE382058T1 AT E382058 T1 ATE382058 T1 AT E382058T1 AT 99908589 T AT99908589 T AT 99908589T AT 99908589 T AT99908589 T AT 99908589T AT E382058 T1 ATE382058 T1 AT E382058T1
Authority
AT
Austria
Prior art keywords
protein
gpcr
receptor antagonists
coupled receptor
transmembrane helices
Prior art date
Application number
AT99908589T
Other languages
English (en)
Inventor
Nadya I Tarasova
Christopher Michejda
Original Assignee
Us Gov Health & Human Serv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv filed Critical Us Gov Health & Human Serv
Application granted granted Critical
Publication of ATE382058T1 publication Critical patent/ATE382058T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99908589T 1998-02-27 1999-02-26 G-protein-gekoppelte rezeptor-antagonisten ATE382058T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7610598P 1998-02-27 1998-02-27

Publications (1)

Publication Number Publication Date
ATE382058T1 true ATE382058T1 (de) 2008-01-15

Family

ID=22129957

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99908589T ATE382058T1 (de) 1998-02-27 1999-02-26 G-protein-gekoppelte rezeptor-antagonisten

Country Status (7)

Country Link
EP (1) EP1056778B1 (de)
AT (1) ATE382058T1 (de)
AU (1) AU760208B2 (de)
CA (1) CA2321962C (de)
DE (1) DE69937822T2 (de)
ES (1) ES2299242T3 (de)
WO (1) WO1999043711A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6743594B1 (en) 1995-06-06 2004-06-01 Human Genome Sciences, Inc. Methods of screening using human G-protein chemokine receptor HDGNR10 (CCR5)
US6025154A (en) 1995-06-06 2000-02-15 Human Genome Sciences, Inc. Polynucleotides encoding human G-protein chemokine receptor HDGNR10
US7888466B2 (en) 1996-01-11 2011-02-15 Human Genome Sciences, Inc. Human G-protein chemokine receptor HSATU68
WO2001016182A2 (en) * 1999-08-27 2001-03-08 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services POLYPEPTIDES THAT BIND HIV gp120 AND RELATED NUCLEIC ACIDS, ANTIBODIES, COMPOSITIONS, AND METHODS OF USE
US7304127B2 (en) 1999-08-27 2007-12-04 United States Of America As Represented By The Secretary, Department Of Health And Human Services Polypeptides that bind HIV gp120 and related nucleic acids, antibodies, compositions, and methods of use
US7517849B1 (en) 1999-11-18 2009-04-14 The United States Of America As Represented By The Secretary Of Health And Human Services Inhibition of ABC transporters by transmembrane domain analogs
AU2001257169C1 (en) 2000-04-21 2011-06-16 Tufts Medical Center, Inc. G-protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same
US7696168B2 (en) 2000-04-21 2010-04-13 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
CN1564826A (zh) 2001-02-09 2005-01-12 人类基因组科学公司 人类g蛋白趋化因子受体(ccr5)hdgnr10
US7056889B2 (en) * 2002-12-16 2006-06-06 Kimberly-Clark, Worldwide, Inc. Compounds that bind P2Y2 or P2Y1 receptors
US20080220445A1 (en) * 2004-10-01 2008-09-11 Takeda Pharmaceutical Company Limited Method of Screening Transmembrane Enzyme Inhibitory Substance
CN101094866A (zh) 2004-11-04 2007-12-26 新英格兰医疗中心医院有限公司 G蛋白耦合受体激动剂和拮抗剂及其使用方法
WO2006113557A2 (en) * 2005-04-15 2006-10-26 Board Of Trustees Of Michigan State University Gpcr modulators
EP2004675A1 (de) 2006-03-16 2008-12-24 Protagonists Ltd. Kombination von cytokin und cytokinrezeptor zur modulation der funktion des immunsystems
CN101610759A (zh) * 2006-11-07 2009-12-23 美国政府卫生与公共服务部 由跨膜肽组成的自组装纳米颗粒及其用于特异性肿瘤内递送抗癌药物的应用
US20130183696A1 (en) * 2010-09-15 2013-07-18 Constance Neely Wilson Methods of use and kit for measurement of lipopolysaccharide with a time resolved fluorescence based assay
DK3050574T3 (da) 2015-01-28 2020-01-20 Univ Bordeaux Anvendelse af plerixafor til behandling og/eller forebyggelse af akutte forværringer af kronisk obstruktiv lungesygdom
WO2016130899A1 (en) 2015-02-13 2016-08-18 The Board Of Trustees Of The University Of Illinois Peptide inhibition of ccr3-mediated diseases or conditions
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997028258A1 (en) * 1996-01-30 1997-08-07 The National Institutes Of Health Cells expressing both human cd4 and cxcr4
WO1997035881A2 (en) * 1996-03-27 1997-10-02 Ng Gordon Y K Receptor and transporter antagonists
WO1998000538A2 (en) * 1996-07-01 1998-01-08 Biosignal Inc. Peptides and peptidomimetic compounds affecting the activity of g-protein-coupled receptors by altering receptor oligomerization

Also Published As

Publication number Publication date
DE69937822D1 (de) 2008-02-07
AU760208B2 (en) 2003-05-08
ES2299242T3 (es) 2008-05-16
CA2321962C (en) 2014-07-15
DE69937822T2 (de) 2009-01-22
AU2798499A (en) 1999-09-15
WO1999043711A1 (en) 1999-09-02
CA2321962A1 (en) 1999-09-02
EP1056778A1 (de) 2000-12-06
EP1056778B1 (de) 2007-12-26

Similar Documents

Publication Publication Date Title
DE69937822D1 (de) G-protein-gekoppelte rezeptor-antagonisten
ATE318311T1 (de) Nicht-endogene, konstitutiv aktivierte, menschliche, an ein g-protein gekoppelte rezeptoren
Münch et al. Multisite contacts involved in coupling of the β‐adrenergic receptor with the stimulatory guanine‐nucleotide‐binding regulatory protein: Structural and functional studies by β‐receptor‐site‐specific synthetic peptides
DK0726952T3 (da) Receptor benævnt ACT-4 på overfladen af aktiverede T-celler
WO2002103005A1 (en) Guanosine triphosphate-binding protein-coupled receptors
PT1133559E (pt) Receptor acoplato a proteina g orfao humano, rup3
DE69534741D1 (de) In hefe exprimierte heteologe g-protein-gekoppelte rezeptoren, fusionen desselben mit g-proteinen und deren verwendung im biotest
Hoffmann et al. Residues within transmembrane helices 2 and 5 of the human gonadotropin-releasing hormone receptor contribute to agonist and antagonist binding
CY1108054T1 (el) Θεραπεια της δυσκινησιας μεσω ανταγωνιστων επιλεκτικων οπιουχων mu
Lee et al. Design and synthesis of novel hydrazide-linked bifunctional peptides as δ/μ opioid receptor agonists and CCK-1/CCK-2 receptor antagonists
Bermak et al. Accessory proteins in the biogenesis of G protein-coupled receptors
AU2003293959A1 (en) Millisecond activation switch for seven-transmembrane proteins
DK0692026T3 (da) En human T-cellereceptor fra den G-proteinkoblede receptorfamilie
US20190309022A1 (en) Novel modulators of melanocortin receptors
DE69809242D1 (de) Neue pyrimidinderivate
Takeda et al. The receptor-Gα fusion protein as a tool for ligand screening: a model study using a nociceptin receptor-Gαi2 fusion protein
ES2172939T3 (es) Nuevos compuestos que son antagonistas de receptores acoplados a proteina g de 7-transmembrana (tm) de p2-purinoceptores.
EA200000197A1 (ru) 2-ациламинопропанамины в качестве антагонистов рецепторов тахикининов
ATE343634T1 (de) Gaba b-rezeptor-subtypen gaba b-r1c und gaba b-r2 und deren heterodimere
WO2003082320A1 (fr) Nouveau procede de criblage
EP1140968A4 (de) Dna-moleküle kodierende spleissvarianten des humanen melanocortin-1-rezeptorproteins
AU2501297A (en) Peptide antagonists derived from the transmembrane domains of g protein-coupled receptors
DE60036712D1 (de) G-Protein gekoppelter REZEPTOR
DE602004023493D1 (de) Neues screening-verfahren
AU2002213016A1 (en) G-protein fusion receptors and chimeric gabab receptors

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties