ATE366324T1 - Inhibierung eines fgf-bindungsproteins durch ribozyme - Google Patents
Inhibierung eines fgf-bindungsproteins durch ribozymeInfo
- Publication number
- ATE366324T1 ATE366324T1 AT98950713T AT98950713T ATE366324T1 AT E366324 T1 ATE366324 T1 AT E366324T1 AT 98950713 T AT98950713 T AT 98950713T AT 98950713 T AT98950713 T AT 98950713T AT E366324 T1 ATE366324 T1 AT E366324T1
- Authority
- AT
- Austria
- Prior art keywords
- fgf
- ribozymes
- binding protein
- mrna
- found
- Prior art date
Links
- 102000053642 Catalytic RNA Human genes 0.000 title abstract 3
- 108090000994 Catalytic RNA Proteins 0.000 title abstract 3
- 108091092562 ribozyme Proteins 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 101150021185 FGF gene Proteins 0.000 abstract 2
- 108020004999 messenger RNA Proteins 0.000 abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000002491 angiogenic effect Effects 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 230000005713 exacerbation Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000001960 triggered effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6017097P | 1997-09-26 | 1997-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366324T1 true ATE366324T1 (de) | 2007-07-15 |
Family
ID=22027820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98950713T ATE366324T1 (de) | 1997-09-26 | 1998-09-25 | Inhibierung eines fgf-bindungsproteins durch ribozyme |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6245748B1 (de) |
| EP (1) | EP1034301B1 (de) |
| JP (1) | JP2001517461A (de) |
| AT (1) | ATE366324T1 (de) |
| AU (1) | AU9669498A (de) |
| CA (1) | CA2304987C (de) |
| DE (1) | DE69838035D1 (de) |
| WO (1) | WO1999015703A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19956568A1 (de) * | 1999-01-30 | 2000-08-17 | Roland Kreutzer | Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens |
| US7829693B2 (en) * | 1999-11-24 | 2010-11-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
| US8546143B2 (en) | 2001-01-09 | 2013-10-01 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of a target gene |
-
1998
- 1998-09-25 DE DE69838035T patent/DE69838035D1/de not_active Expired - Lifetime
- 1998-09-25 US US09/160,588 patent/US6245748B1/en not_active Expired - Lifetime
- 1998-09-25 EP EP98950713A patent/EP1034301B1/de not_active Expired - Lifetime
- 1998-09-25 CA CA002304987A patent/CA2304987C/en not_active Expired - Fee Related
- 1998-09-25 AU AU96694/98A patent/AU9669498A/en not_active Abandoned
- 1998-09-25 JP JP2000512990A patent/JP2001517461A/ja active Pending
- 1998-09-25 AT AT98950713T patent/ATE366324T1/de not_active IP Right Cessation
- 1998-09-25 WO PCT/US1998/020208 patent/WO1999015703A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001517461A (ja) | 2001-10-09 |
| EP1034301A1 (de) | 2000-09-13 |
| EP1034301A4 (de) | 2005-04-06 |
| CA2304987A1 (en) | 1999-04-01 |
| DE69838035D1 (de) | 2007-08-16 |
| US6245748B1 (en) | 2001-06-12 |
| EP1034301B1 (de) | 2007-07-04 |
| WO1999015703A1 (en) | 1999-04-01 |
| AU9669498A (en) | 1999-04-12 |
| CA2304987C (en) | 2005-05-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |