ATE358672T1 - Antitumor verbindungen basierend auf der regulierung von protein prenylation - Google Patents
Antitumor verbindungen basierend auf der regulierung von protein prenylationInfo
- Publication number
- ATE358672T1 ATE358672T1 AT01981790T AT01981790T ATE358672T1 AT E358672 T1 ATE358672 T1 AT E358672T1 AT 01981790 T AT01981790 T AT 01981790T AT 01981790 T AT01981790 T AT 01981790T AT E358672 T1 ATE358672 T1 AT E358672T1
- Authority
- AT
- Austria
- Prior art keywords
- prenylation
- group
- enzyme
- compounds
- cancer cell
- Prior art date
Links
- 230000013823 prenylation Effects 0.000 title abstract 5
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 3
- 108090000790 Enzymes Proteins 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 150000003564 thiocarbonyl compounds Chemical class 0.000 abstract 2
- 101150054980 Rhob gene Proteins 0.000 abstract 1
- 102000004357 Transferases Human genes 0.000 abstract 1
- 108090000992 Transferases Proteins 0.000 abstract 1
- 230000032823 cell division Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 230000009849 deactivation Effects 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 125000001165 hydrophobic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 230000000116 mitigating effect Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 102000027450 oncoproteins Human genes 0.000 abstract 1
- 108091008819 oncoproteins Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/46—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/62—Halogen-containing esters
- C07C69/63—Halogen-containing esters of saturated acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24195500P | 2000-10-23 | 2000-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE358672T1 true ATE358672T1 (de) | 2007-04-15 |
Family
ID=22912873
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01981790T ATE358672T1 (de) | 2000-10-23 | 2001-10-23 | Antitumor verbindungen basierend auf der regulierung von protein prenylation |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US7019031B2 (de) |
| EP (2) | EP1798217A1 (de) |
| JP (1) | JP2004533407A (de) |
| AT (1) | ATE358672T1 (de) |
| AU (1) | AU2002213408A1 (de) |
| CA (1) | CA2426203A1 (de) |
| DE (1) | DE60127705T2 (de) |
| WO (1) | WO2002034247A2 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004533407A (ja) | 2000-10-23 | 2004-11-04 | ジ・アリゾナ・ディジーズ・コントロール・リサーチ・コミッション | タンパク質プレニル化の調節に基づく抗癌剤 |
| AU2003243272A1 (en) * | 2002-05-22 | 2003-12-12 | Errant Gene Therapeutics, Llc | Histone deacetylase inhibitors based on alpha-ketoepoxide compounds |
| EP1582219A4 (de) * | 2002-11-29 | 2007-11-28 | Japan Science & Tech Agency | Connexin 26 inhibitoren und inhibitoren von tumormetastasen |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1599532A (en) * | 1924-07-31 | 1926-09-14 | Charles A Humphreys | Key case |
| SE7802416L (sv) | 1977-04-04 | 1978-10-05 | Shell Int Research | Lipogenesis-inhibitorer |
| US4235923A (en) * | 1979-05-04 | 1980-11-25 | Shell Oil Company | Esters of 3-substituted-2-(aminocarbonyl)oxiranecarboxylic acids as lipogenesis inhibitors |
| EP0147217A3 (de) * | 1983-12-27 | 1986-08-13 | Merck Frosst Canada Inc. | Leukotrienen-Antagonisten |
| IL75620A (en) * | 1984-06-28 | 1989-05-15 | Ciba Geigy | Aliphatic thioethers of alkanoic acid derivatives,their manufacture and pharmaceutical compositions containing them |
| CA1280414C (en) * | 1985-03-15 | 1991-02-19 | Saichi Matsumoto | Isoprenoidamine derivatives and antiulcer agents |
| KR870011086A (ko) * | 1986-05-29 | 1987-12-19 | 벤자민 에프. 램버트 | 포스포리파제 a₂억제제 및 그의 합성방법 |
| FI94342C (fi) * | 1988-03-29 | 1995-08-25 | Ciba Geigy Ag | Menetelmä uusien alkanofenonien valmistamiseksi |
| DE3823803A1 (de) | 1988-07-14 | 1990-01-18 | Basf Ag | Thermoplastische formmassen auf der basis von polyamidmischungen |
| EP0410244A1 (de) * | 1989-07-27 | 1991-01-30 | Bayer Ag | Leukotrienantagonisten |
| FR2660655A1 (fr) * | 1990-04-09 | 1991-10-11 | Fournier Sca Laboratoires | Antagonistes de leucotrienes, leur procede de preparation et leur utilisation en therapeutique. |
| US5298655A (en) | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
| GB9209628D0 (en) * | 1992-05-05 | 1992-06-17 | Smithkline Beecham Plc | Compounds |
| JPH072821A (ja) * | 1993-06-17 | 1995-01-06 | Yamanouchi Pharmaceut Co Ltd | 新規抗生物質及びその製造法 |
| GB9400047D0 (en) * | 1994-01-04 | 1994-03-02 | Norsk Hydro As | Pharmaceutical compositions |
| EP0752465A1 (de) * | 1995-06-01 | 1997-01-08 | The Procter & Gamble Company | Alkoholfreisetzende Betainester |
| US5733911A (en) * | 1996-01-26 | 1998-03-31 | Hitachi Chemical Co., Ltd. | Method for inducing death of neoplastic cells using piperazne derivatives |
| JP3159060B2 (ja) | 1996-06-14 | 2001-04-23 | 日本精機株式会社 | 半導体チップの接合構造及びその接合方法 |
| FR2781228B1 (fr) * | 1998-07-16 | 2000-09-29 | Pf Medicament | Phosphonates insatures derives d'indole |
| WO2000033826A1 (en) * | 1998-12-09 | 2000-06-15 | The Arizona Disease Control Research Commission | Anticancer agents based on prevention of protein prenylation |
| JP2004533407A (ja) | 2000-10-23 | 2004-11-04 | ジ・アリゾナ・ディジーズ・コントロール・リサーチ・コミッション | タンパク質プレニル化の調節に基づく抗癌剤 |
-
2001
- 2001-10-23 JP JP2002537301A patent/JP2004533407A/ja active Pending
- 2001-10-23 US US09/983,232 patent/US7019031B2/en not_active Expired - Fee Related
- 2001-10-23 EP EP07075174A patent/EP1798217A1/de not_active Withdrawn
- 2001-10-23 CA CA002426203A patent/CA2426203A1/en not_active Abandoned
- 2001-10-23 DE DE60127705T patent/DE60127705T2/de not_active Expired - Fee Related
- 2001-10-23 WO PCT/US2001/032618 patent/WO2002034247A2/en active IP Right Grant
- 2001-10-23 AT AT01981790T patent/ATE358672T1/de not_active IP Right Cessation
- 2001-10-23 EP EP01981790A patent/EP1332139B1/de not_active Expired - Lifetime
- 2001-10-23 AU AU2002213408A patent/AU2002213408A1/en not_active Abandoned
-
2006
- 2006-01-23 US US11/275,662 patent/US7423170B2/en not_active Expired - Fee Related
-
2008
- 2008-09-04 US US12/204,585 patent/US7943665B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002034247A3 (en) | 2003-01-16 |
| US7019031B2 (en) | 2006-03-28 |
| DE60127705T2 (de) | 2007-12-27 |
| US20060111329A1 (en) | 2006-05-25 |
| US7943665B2 (en) | 2011-05-17 |
| US7423170B2 (en) | 2008-09-09 |
| AU2002213408A1 (en) | 2002-05-06 |
| EP1332139A2 (de) | 2003-08-06 |
| JP2004533407A (ja) | 2004-11-04 |
| CA2426203A1 (en) | 2002-05-02 |
| US20020086884A1 (en) | 2002-07-04 |
| EP1798217A1 (de) | 2007-06-20 |
| DE60127705D1 (de) | 2007-05-16 |
| US20090143467A1 (en) | 2009-06-04 |
| WO2002034247A2 (en) | 2002-05-02 |
| EP1332139B1 (de) | 2007-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |