ATE346297T1 - Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen - Google Patents

Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen

Info

Publication number
ATE346297T1
ATE346297T1 AT03770419T AT03770419T ATE346297T1 AT E346297 T1 ATE346297 T1 AT E346297T1 AT 03770419 T AT03770419 T AT 03770419T AT 03770419 T AT03770419 T AT 03770419T AT E346297 T1 ATE346297 T1 AT E346297T1
Authority
AT
Austria
Prior art keywords
cantilever
detection
counterbalancing force
analytes
canomy
Prior art date
Application number
AT03770419T
Other languages
English (en)
Inventor
Xing Su
Selena Chan
Tae-Woong Koo
Mineo Yamakawa
Andrew Berlin
Original Assignee
Intel Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/254,201 external-priority patent/US7270952B2/en
Application filed by Intel Corp filed Critical Intel Corp
Application granted granted Critical
Publication of ATE346297T1 publication Critical patent/ATE346297T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/924—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis using nanostructure as support of dna analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Length Measuring Devices With Unspecified Measuring Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Pressure Sensors (AREA)
  • Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)
  • Steering Control In Accordance With Driving Conditions (AREA)
  • Control Of Position, Course, Altitude, Or Attitude Of Moving Bodies (AREA)
AT03770419T 2002-09-24 2003-09-24 Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen ATE346297T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/254,201 US7270952B2 (en) 2002-09-24 2002-09-24 Detecting molecular binding by monitoring feedback controlled cantilever deflections
US10/667,776 US7105301B2 (en) 2002-09-24 2003-09-22 Detecting molecular binding by monitoring feedback controlled cantilever deflections

Publications (1)

Publication Number Publication Date
ATE346297T1 true ATE346297T1 (de) 2006-12-15

Family

ID=32829360

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03770419T ATE346297T1 (de) 2002-09-24 2003-09-24 Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen

Country Status (8)

Country Link
US (1) US7291466B2 (de)
EP (1) EP1543328B1 (de)
JP (1) JP4398375B2 (de)
CN (1) CN100342235C (de)
AT (1) ATE346297T1 (de)
AU (1) AU2003278903A1 (de)
DE (1) DE60309903T2 (de)
WO (1) WO2004029625A2 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090288479A1 (en) * 2003-11-17 2009-11-26 Woody Shane C Standing wave fluidic and biological tools
US20060157684A1 (en) * 2004-12-15 2006-07-20 The Regents Of The University Of California Thin film multilayer with nanolayers addressable from the macroscale
CN100458431C (zh) * 2004-12-30 2009-02-04 中国科学院电工研究所 一种利用微悬臂梁进行生化检测的装置
EP1705486B1 (de) 2005-02-05 2008-03-19 Samsung Electronics Co., Ltd. Sensorschalter und seine Verwendung in einem Nachweisverfahren
JP2009509124A (ja) * 2005-06-16 2009-03-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 大型のパラレルの免疫ベースのアレルギー試験および蛍光のエバネセント場励起のためのデバイス
TWI293682B (en) * 2006-02-24 2008-02-21 Yuan Jay Wang Multipurpose micro cantilever sensing sensitivity control device
US20080011058A1 (en) * 2006-03-20 2008-01-17 The Regents Of The University Of California Piezoresistive cantilever based nanoflow and viscosity sensor for microchannels
US7709264B2 (en) * 2006-09-21 2010-05-04 Philip Morris Usa Inc. Handheld microcantilever-based sensor for detecting tobacco-specific nitrosamines
US7716965B2 (en) * 2006-10-27 2010-05-18 Ut-Battelle, Llc Electrochemical sensor having suspended element counter electrode and deflection method for current sensing
US8168120B1 (en) 2007-03-06 2012-05-01 The Research Foundation Of State University Of New York Reliable switch that is triggered by the detection of a specific gas or substance
US8191403B2 (en) * 2007-03-27 2012-06-05 Richmond Chemical Corporation Petroleum viscosity measurement and communication system and method
EP2053400A1 (de) * 2007-10-22 2009-04-29 Consejo Superior De Investigaciones Cientificas Verfahren und System zur Erkennung einer ausgewählten Molekülart in einer Probe
US7928343B2 (en) * 2007-12-04 2011-04-19 The Board Of Trustees Of The University Of Illinois Microcantilever heater-thermometer with integrated temperature-compensated strain sensor
CN101221166B (zh) * 2008-01-22 2011-09-14 西北工业大学 三维培养条件下细胞应变加载装置
US8719960B2 (en) 2008-01-31 2014-05-06 The Board Of Trustees Of The University Of Illinois Temperature-dependent nanoscale contact potential measurement technique and device
KR100975010B1 (ko) * 2008-02-29 2010-08-09 성균관대학교산학협력단 다중 크기 압전 마이크로 칸티레버 공진자 어레이를 이용한 물리센서 및 그 제작방법
US20090241681A1 (en) * 2008-03-27 2009-10-01 Andrew Machauf Hydrogel-based mems biosensor
US8093667B2 (en) * 2008-06-30 2012-01-10 Intel Corporation Flexible gate electrode device for bio-sensing
US8931950B2 (en) 2008-08-20 2015-01-13 The Board Of Trustees Of The University Of Illinois Device for calorimetric measurement
US20100099076A1 (en) * 2008-10-16 2010-04-22 Kent State University Sensitive and rapid detection of viral particles in early viral infection by laser tweezers
US8387443B2 (en) 2009-09-11 2013-03-05 The Board Of Trustees Of The University Of Illinois Microcantilever with reduced second harmonic while in contact with a surface and nano scale infrared spectrometer
US20110086368A1 (en) * 2009-10-08 2011-04-14 Drexel University Method for immune response detection
JP2013524258A (ja) 2010-04-14 2013-06-17 ナノインク インコーポレーティッド 付着用のカンチレバー
US20110277193A1 (en) 2010-04-20 2011-11-10 Nanolnk, Inc. Sensors and biosensors
US9267923B2 (en) 2010-11-01 2016-02-23 Koc Universitesi Miniaturized integrated micro electro-mechanical systems (MEMS) optical sensor array
CN102252753A (zh) * 2011-04-18 2011-11-23 中国科学院半导体研究所 基于光压效应的红外光子探测方法
GB2491806B (en) * 2011-05-25 2013-07-10 Microvisk Ltd Apparatus and method for measuring properties of a fluid
US8914911B2 (en) 2011-08-15 2014-12-16 The Board Of Trustees Of The University Of Illinois Magnetic actuation and thermal cantilevers for temperature and frequency dependent atomic force microscopy
US8533861B2 (en) 2011-08-15 2013-09-10 The Board Of Trustees Of The University Of Illinois Magnetic actuation and thermal cantilevers for temperature and frequency dependent atomic force microscopy
GB2508358B (en) 2012-11-28 2014-10-29 Microvisk Ltd Apparatus and method for monitoring a sedimentation parameter in a fluid medium sample
CN103207035B (zh) * 2013-05-14 2015-07-15 南京因艾生生物科技有限公司 一种用于测量分子间作用力的力谱仪
US9366651B2 (en) * 2013-07-03 2016-06-14 Matrix Sensors, Inc. Array of sensors with surface modifications
KR102316324B1 (ko) * 2015-03-24 2021-10-22 엘지전자 주식회사 인플루엔자 검출용 센서
CN106124104A (zh) * 2016-06-13 2016-11-16 常州大学 一种测量基因片段作用力的微悬臂梁装置
CN106124105A (zh) * 2016-06-13 2016-11-16 常州大学 利用弯曲变形测量dna分子间作用力的方法
CN105950461B (zh) * 2016-07-20 2017-10-24 江苏瑞明生物科技有限公司 单细胞纳米精准给药系统
FR3060803B1 (fr) 2016-12-20 2021-12-10 Ondilo Procede pour maintenir un equilibre d'un parametre physico-chimique d'un milieu, produit programme d'ordinateur et moyen electronique associes
CN106501349B (zh) * 2017-01-05 2019-05-14 中国科学院化学研究所 一种基于光学原子磁力仪的原位力谱方法
CN108469399A (zh) * 2018-05-09 2018-08-31 南京煦源生物科技有限公司 固相表面与溶液的运动方式及运动装置
ES2776702B2 (es) * 2019-01-31 2020-12-22 Consejo Superior Investigacion Metodo y sistema para la identificacion de particulas basado en mediciones multifrecuencia de placas resonantes
US11209369B2 (en) * 2019-09-30 2021-12-28 United States Of America, As Represented By The Secretary Of The Army Measuring deflection to determine a characteristic of a cantilever
DE102021107255B4 (de) * 2021-03-23 2024-06-27 digid GmbH Digitaler Sensor mit Referenzkantilever zur Umwandlung chemischer und/oder biochemischer Information
DE102021107254B4 (de) * 2021-03-23 2024-06-27 digid GmbH Digitale Sensorvorrichtung zur Detektion eines Analyten in einer Probe

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4196265A (en) * 1977-06-15 1980-04-01 The Wistar Institute Method of producing antibodies
US6379895B1 (en) * 1989-06-07 2002-04-30 Affymetrix, Inc. Photolithographic and other means for manufacturing arrays
US6346413B1 (en) * 1989-06-07 2002-02-12 Affymetrix, Inc. Polymer arrays
US5106729A (en) * 1989-07-24 1992-04-21 Arizona Board Of Regents Acting On Behalf Of Arizona State University Method for visualizing the base sequence of nucleic acid polymers
ATE132367T1 (de) * 1991-02-14 1996-01-15 Baxter Int Bindung substratspezifischer affinitätssubstanzen an liposomen
US5603872A (en) * 1991-02-14 1997-02-18 Baxter International Inc. Method of binding recognizing substances to liposomes
US5329028A (en) * 1992-08-05 1994-07-12 Genentech, Inc. Carbohydrate-directed cross-linking reagents
FR2703693B1 (fr) * 1993-04-06 1995-07-13 Pasteur Institut Procédé rapide de détermination d'une séquence d'ADN et application au séquençage et au diagnostic.
US5515719A (en) * 1994-05-19 1996-05-14 Molecular Imaging Corporation Controlled force microscope for operation in liquids
US5607568A (en) * 1995-03-16 1997-03-04 International Business Machines Corporation Assembly suitable for identifying a code sequence of a biomolecule in a free-solution embodiment
US5824470A (en) * 1995-05-30 1998-10-20 California Institute Of Technology Method of preparing probes for sensing and manipulating microscopic environments and structures
US5578976A (en) * 1995-06-22 1996-11-26 Rockwell International Corporation Micro electromechanical RF switch
WO1997004283A2 (en) * 1995-07-20 1997-02-06 Cornell Research Foundation, Inc. Microfabricated torsional cantilevers for sensitive force detection
US5807758A (en) * 1995-07-21 1998-09-15 Lee; Gil U. Chemical and biological sensor using an ultra-sensitive force transducer
WO1997009584A1 (en) * 1995-09-01 1997-03-13 International Business Machines Corporation Cantilever with integrated deflection sensor
JP2918066B2 (ja) * 1995-09-29 1999-07-12 インターナシヨナル・ビジネス・マシーンズ・コーポレーシヨン マイクロメカニカル発振器及びインテリジェント音響検出器に基づく機械的信号プロセッサ並びにそれに基づくシステム
EP0886758B1 (de) * 1996-03-13 2001-11-21 International Business Machines Corporation Auslegerstrukturen
US6033852A (en) * 1996-09-27 2000-03-07 University Of Maine Monolithic piezoelectric sensor (MPS) for sensing chemical, biochemical and physical measurands
JP4532608B2 (ja) * 1997-02-07 2010-08-25 オリンパス株式会社 走査型プローブ顕微鏡を用いた核酸検出方法
US6203983B1 (en) * 1997-06-16 2001-03-20 Affymetrix, Inc. Method for detecting chemical interactions between naturally occurring bio-polymers which are non-identical binding partners
US6123819A (en) * 1997-11-12 2000-09-26 Protiveris, Inc. Nanoelectrode arrays
US6016686A (en) * 1998-03-16 2000-01-25 Lockheed Martin Energy Research Corporation Micromechanical potentiometric sensors
US6280939B1 (en) * 1998-09-01 2001-08-28 Veeco Instruments, Inc. Method and apparatus for DNA sequencing using a local sensitive force detector
GB9819319D0 (en) * 1998-09-05 1998-10-28 Aea Technology Plc Assay of chemical binding
US6146227A (en) * 1998-09-28 2000-11-14 Xidex Corporation Method for manufacturing carbon nanotubes as functional elements of MEMS devices
US6289717B1 (en) * 1999-03-30 2001-09-18 U. T. Battelle, Llc Micromechanical antibody sensor
WO2001014823A1 (en) * 1999-08-19 2001-03-01 The Regents Of The University Of California Apparatus and method for visually identifying micro-forces with a palette of cantilever array blocks
EP1226437B1 (de) * 1999-11-03 2004-08-11 International Business Machines Corporation Sensoren und wandler mit freitragendem ausleger

Also Published As

Publication number Publication date
US20050244820A1 (en) 2005-11-03
JP4398375B2 (ja) 2010-01-13
AU2003278903A8 (en) 2004-04-19
AU2003278903A1 (en) 2004-04-19
CN1685233A (zh) 2005-10-19
WO2004029625A3 (en) 2004-08-12
DE60309903T2 (de) 2007-10-18
DE60309903D1 (de) 2007-01-04
EP1543328A2 (de) 2005-06-22
JP2006500587A (ja) 2006-01-05
EP1543328B1 (de) 2006-11-22
CN100342235C (zh) 2007-10-10
WO2004029625A2 (en) 2004-04-08
US7291466B2 (en) 2007-11-06

Similar Documents

Publication Publication Date Title
ATE346297T1 (de) Nachweis von molecularbindung durch überwachung von rückkopplung kontrollierten auslegerablenkungen
MY134398A (en) Detecting molecular binding by monitoring feedback controlled cantilever deflections
Löf et al. Multiplexed protein force spectroscopy reveals equilibrium protein folding dynamics and the low-force response of von Willebrand factor
Stroh et al. Single-molecule recognition imaging microscopy
Kruusamäe et al. Self‐sensing ionic polymer–metal composite actuating device with patterned surface electrodes
ATE355523T1 (de) Nachweisverfahren unter verwendung eines mikromechanischen antikörpersensors
WO2009143522A4 (en) Preamplifying cantilever and applications thereof
Aggarwal et al. Detection of steps in single molecule data
US20180164165A1 (en) Devices and methods to stimulate motion in magnetoelastic beams
Adams et al. Piezoelectric self-sensing of adsorption-induced microcantilever bending
Rajput et al. The nano-scale viscoelasticity using atomic force microscopy in liquid environment
Dey et al. Membrane Tethering of SepF, a Membrane Anchor for the Mycobacterium tuberculosis Z-ring
US7958563B2 (en) Method for using an atomic force microscope
Fu et al. Quantitative electromechanical impedance method for nondestructive testing based on a piezoelectric bimorph cantilever
Archibald et al. Independent component analysis of nanomechanical responses of cantilever arrays
WO2003064991A3 (en) Method and apparatus using a nonlinear optical technique for detection of probe-target interactions in a field
Koirala et al. Mechanical affinity as a new metrics to evaluate binding events
García‐Massó et al. Automated detection of protein unfolding events in atomic force microscopy force curves
Thormann et al. Dynamic force spectroscopy on soft molecular systems: improved analysis of unbinding spectra with varying linker compliance
Moreno Ostertag et al. Tether-length dependence of bias in equilibrium free-energy estimates for surface-to-molecule unbinding experiments
AU2001266128A1 (en) Method and device for assessing the surface condition of a material
Serpe et al. A simple and practical spreadsheet-based method to extract single-molecule dissociation kinetics from variable loading-rate force spectroscopy data
Xu et al. A model-based approach to compensate for the dynamics convolution effect on nanomechanical property measurement
Zhang et al. Noise analysis in parametric resonance based mass sensing
Vértesy et al. Minor hysteresis loops measurements for characterization of cast iron

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties