ATE345806T1 - ARTIFICIAL OXYGEN CARRIER MADE OF CROSS-LINKED MODIFIED HUMAN OR SWINE HEMOGLOBIN, METHOD FOR THE PRODUCTION THEREOF FROM PURIFIED MATERIAL, AND THEIR USE - Google Patents

ARTIFICIAL OXYGEN CARRIER MADE OF CROSS-LINKED MODIFIED HUMAN OR SWINE HEMOGLOBIN, METHOD FOR THE PRODUCTION THEREOF FROM PURIFIED MATERIAL, AND THEIR USE

Info

Publication number
ATE345806T1
ATE345806T1 AT01962733T AT01962733T ATE345806T1 AT E345806 T1 ATE345806 T1 AT E345806T1 AT 01962733 T AT01962733 T AT 01962733T AT 01962733 T AT01962733 T AT 01962733T AT E345806 T1 ATE345806 T1 AT E345806T1
Authority
AT
Austria
Prior art keywords
cross
production
oxygen carrier
artificial oxygen
modified human
Prior art date
Application number
AT01962733T
Other languages
German (de)
Inventor
Wolfgang Barnikol
Oswald Burkhard
Harald Poetzschke
Ulrike Domack
Stephanie Dinkelmann
Bernd Fiedler
Birgit Manz
Original Assignee
Sanguibiotech Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanguibiotech Gmbh filed Critical Sanguibiotech Gmbh
Application granted granted Critical
Publication of ATE345806T1 publication Critical patent/ATE345806T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

According to the claims, the present invention comprises the preparation of chemically modified, cross-linked hemoglobins with improved functional properties, the cross-linked hemoglobins prepared according to this method and the use of these hemoglobins as artificial oxygen carriers. The synthesis method is characterized by technical simplicity as well as by high yields.
AT01962733T 2000-06-29 2001-06-12 ARTIFICIAL OXYGEN CARRIER MADE OF CROSS-LINKED MODIFIED HUMAN OR SWINE HEMOGLOBIN, METHOD FOR THE PRODUCTION THEREOF FROM PURIFIED MATERIAL, AND THEIR USE ATE345806T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10031740A DE10031740A1 (en) 2000-06-29 2000-06-29 Artificial oxygen carriers from cross-linked modified human or pig hemoglobin with improved properties, processes for their technically simple production from purified material in high yields, and their use

Publications (1)

Publication Number Publication Date
ATE345806T1 true ATE345806T1 (en) 2006-12-15

Family

ID=7647244

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01962733T ATE345806T1 (en) 2000-06-29 2001-06-12 ARTIFICIAL OXYGEN CARRIER MADE OF CROSS-LINKED MODIFIED HUMAN OR SWINE HEMOGLOBIN, METHOD FOR THE PRODUCTION THEREOF FROM PURIFIED MATERIAL, AND THEIR USE

Country Status (7)

Country Link
US (1) US7005414B2 (en)
EP (1) EP1294386B1 (en)
AT (1) ATE345806T1 (en)
AU (1) AU2001283857A1 (en)
DE (2) DE10031740A1 (en)
ES (1) ES2275712T3 (en)
WO (1) WO2002000230A1 (en)

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US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
DE10031744A1 (en) * 2000-06-29 2002-01-17 Sanguibio Tech Ag Mammalian hemoglobins compatible with blood plasma, crosslinked and conjugated with polyalkylene oxides as artificial medical oxygen carriers, their production and their use
DE20017940U1 (en) 2000-10-19 2000-12-28 Map Gmbh Breathing mask for supplying a breathing gas to a mask user and a derivation device for deriving breathing gas
DE10201682A1 (en) 2002-01-17 2003-07-31 Map Medizin Technologie Gmbh The breathing mask arrangement
DE50214539D1 (en) 2001-10-22 2010-08-26 Map Medizin Technologie Gmbh Medical mask
DE10151984C5 (en) 2001-10-22 2008-07-17 Map Medizin-Technologie Gmbh Application device for a breathing mask arrangement
DE10220992A1 (en) * 2002-05-11 2003-12-04 Sanguibiotech Ag Use of one or more oxygen carriers selected from hemoglobin, myoglobin and derivatives thereof for the treatment of an organ dysfunction due to an acute lack of supply and for the treatment / prevention of tissue damage due to such a disorder
CN103143098B (en) 2002-09-06 2016-03-09 瑞思迈有限公司 The forehead pad of breathing mask
DE10352692A1 (en) * 2003-11-12 2005-06-23 Sanguibiotech Gmbh Use of hypo-oncotic solutions in the blood of addable, hyperpolymeric hemoglobins for the treatment of pulmonary edema
CN106110464B (en) 2004-06-16 2019-03-12 瑞思迈有限公司 The cushion of respiratory mask assembly
NZ588816A (en) 2007-01-21 2011-11-25 Hemoteq Ag Medical device for the treatment of stenoses of corporal lumina and for the prevention of impending restenoses
US9192697B2 (en) * 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
DE102008027133A1 (en) 2008-05-30 2009-12-03 Ls Medcap Gmbh Fully synthetic albumin analog
WO2011005421A2 (en) 2009-07-10 2011-01-13 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
JP5933434B2 (en) * 2009-07-17 2016-06-08 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． Method for producing drug delivery balloon
US20110160645A1 (en) * 2009-12-31 2011-06-30 Boston Scientific Scimed, Inc. Cryo Activated Drug Delivery and Cutting Balloons
ES2370221B1 (en) * 2010-05-20 2012-08-16 Universidad De Huelva ATTRACTING COMPOSITION FOR FOREST INSECTS.
US20120028899A1 (en) * 2010-07-30 2012-02-02 Andre Francis Palmer Composition and process for synthesizing tense and relaxed state polymerized hemoglobin
US8609815B2 (en) 2010-09-02 2013-12-17 Sangart, Inc. Methods for preparing stable deoxygenated PEG-hemoglobin conjugate solutions comprising an antioxidant
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
PL2550973T3 (en) 2011-07-23 2014-03-31 Sastomed Gmbh Wound spray
WO2013022458A1 (en) 2011-08-05 2013-02-14 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
EP2614833A1 (en) 2012-01-13 2013-07-17 SastoMed GmbH Scarring reducing wound treatment
WO2013151776A1 (en) 2012-04-03 2013-10-10 Sangart, Inc. Succinimide-activated nitroxyl compounds and methods for the use thereof for nitroxylation of proteins
KR102238718B1 (en) 2013-03-15 2021-04-12 쉰들러, 윌리엄 Polyalkylene oxide valerate hemoglobin conjugates
DE102013014651A1 (en) 2013-09-03 2015-03-05 Sanguibiotech Gmbh Preparations for improved tissue oxygenation by peritoneal ventilation
EP3092213B1 (en) 2013-12-27 2019-10-23 Virginia Commonwealth University Allosteric hemoglobin modifiers with nitric oxide releasing moiety
EP3421044A1 (en) 2017-06-26 2019-01-02 SastoMed GmbH Oxygen carriers for the treatment of skin indispositions
US11504417B2 (en) 2017-07-18 2022-11-22 VirTech Bio, Inc. Blood substitutes comprising hemoglobin and methods of making

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Also Published As

Publication number Publication date
US7005414B2 (en) 2006-02-28
AU2001283857A1 (en) 2002-01-08
EP1294386B1 (en) 2006-11-22
US20040029780A1 (en) 2004-02-12
WO2002000230A1 (en) 2002-01-03
EP1294386A1 (en) 2003-03-26
DE10031740A1 (en) 2002-02-14
DE50111495D1 (en) 2007-01-04
ES2275712T3 (en) 2007-06-16

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