ATE338273T1 - Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen - Google Patents

Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen

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Publication number
ATE338273T1
ATE338273T1 AT00937613T AT00937613T ATE338273T1 AT E338273 T1 ATE338273 T1 AT E338273T1 AT 00937613 T AT00937613 T AT 00937613T AT 00937613 T AT00937613 T AT 00937613T AT E338273 T1 ATE338273 T1 AT E338273T1
Authority
AT
Austria
Prior art keywords
holder
bundles
bundle
openings
presenting
Prior art date
Application number
AT00937613T
Other languages
English (en)
Inventor
John R Stuelpnagel
Mark S Chee
Richard J Pytelewski
Todd Alan Dickinson
Gan G Wang
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Application granted granted Critical
Publication of ATE338273T1 publication Critical patent/ATE338273T1/de

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251Colorimeters; Construction thereof
    • G01N21/253Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00646Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports
    • B01J2219/00648Making arrays on substantially continuous surfaces the compounds being bound to beads immobilised on the solid supports by the use of solid beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00702Processes involving means for analysing and characterising the products
    • B01J2219/00707Processes involving means for analysing and characterising the products separated from the reactor apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0893Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
AT00937613T 1999-05-20 2000-05-19 Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen ATE338273T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13508999P 1999-05-20 1999-05-20

Publications (1)

Publication Number Publication Date
ATE338273T1 true ATE338273T1 (de) 2006-09-15

Family

ID=22466488

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00937613T ATE338273T1 (de) 1999-05-20 2000-05-19 Vorrichtung zur halterung und präsentation von mindestens einer mikrokugelmatrix zu lösungen und/oder zu optischen abbildungssystemen

Country Status (7)

Country Link
US (1) US6396995B1 (de)
EP (1) EP1190233B1 (de)
AT (1) ATE338273T1 (de)
AU (1) AU779835B2 (de)
CA (1) CA2374596A1 (de)
DE (1) DE60030436T2 (de)
WO (1) WO2000071992A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287850B1 (en) * 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
DE69527585T2 (de) * 1994-06-08 2003-04-03 Affymetrix, Inc. Verfahren und Vorrichtung zum Verpacken von Chips
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6720149B1 (en) * 1995-06-07 2004-04-13 Affymetrix, Inc. Methods for concurrently processing multiple biological chip assays
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
JP4294740B2 (ja) 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
DE69940430D1 (de) * 1998-06-24 2009-04-02 Illumina Inc Dekodierung von matrixartig-angeordneten Sensoren durch Mikropartikel
US7510841B2 (en) * 1998-12-28 2009-03-31 Illumina, Inc. Methods of making and using composite arrays for the detection of a plurality of target analytes
US20060275782A1 (en) 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6620584B1 (en) 1999-05-20 2003-09-16 Illumina Combinatorial decoding of random nucleic acid arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
ATE542916T1 (de) 1999-08-18 2012-02-15 Illumina Inc Methoden zur erzeugung von oligonukleotidlösungen
US7244559B2 (en) 1999-09-16 2007-07-17 454 Life Sciences Corporation Method of sequencing a nucleic acid
US7211390B2 (en) * 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
GB9929668D0 (en) * 1999-12-15 2000-02-09 Moore David F Microclamps
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US7611869B2 (en) 2000-02-07 2009-11-03 Illumina, Inc. Multiplexed methylation detection methods
CA2401962A1 (en) 2000-02-07 2001-08-09 Illumina, Inc. Nucleic acid detection methods using universal priming
EP1990428B1 (de) 2000-02-07 2010-12-22 Illumina, Inc. Nukleinsäuredetektionsverfahren mit universellem Priming
AU2001239760B2 (en) * 2000-02-10 2005-11-24 Illumina, Inc. Array of individual arrays as substrate for bead-based simultaneous processing of samples and manufacturing method therefor
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
WO2001083825A2 (en) * 2000-05-04 2001-11-08 The Center For Blood Research, Inc. Colloid compositions for solid phase biomolecular analytical systems
US6595698B2 (en) * 2000-06-13 2003-07-22 Siwave, Inc. High density fiber terminator/connector
DE10057127A1 (de) * 2000-11-16 2002-06-06 Schott Glas Verfahren zum Verbringen einer Vielzahl von Faserenden in eine vorgegebene Position
US6633707B1 (en) * 2000-12-29 2003-10-14 Intel Corporation Lithographically defined optic array
GB2390155B (en) * 2001-01-03 2004-04-21 Packard Instrument Co Inc Luminescence imager
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
US6827500B2 (en) * 2001-06-29 2004-12-07 Lucent Technologies Inc. Precision two dimensional optical fiber array
US20030015139A1 (en) * 2001-07-17 2003-01-23 3M Innovative Properties Company Protective packaging
WO2003022421A2 (en) * 2001-09-07 2003-03-20 Corning Incorporated Microcolumn-platform based array for high-throughput analysis
US7024090B2 (en) * 2001-09-26 2006-04-04 Shipley Company, L.L.C. Optical fiber array with variable fiber angle alignment and method for the fabrication thereof
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US6956114B2 (en) 2001-10-30 2005-10-18 '454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
AU2003208935A1 (en) * 2002-02-07 2003-09-02 The Regents Of The University Of California Optically encoded particles
US7499806B2 (en) 2002-02-14 2009-03-03 Illumina, Inc. Image processing in microsphere arrays
US20040132173A1 (en) * 2002-08-28 2004-07-08 Kimon Angelides Optical fiber array device capable of simultaneously performing multiple functional assays
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
US7575865B2 (en) 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
AU2004209426B2 (en) 2003-01-29 2008-04-17 454 Life Sciences Corporation Method for preparing single-stranded DNA libraries
US8652774B2 (en) * 2003-04-16 2014-02-18 Affymetrix, Inc. Automated method of manufacturing polyer arrays
US6816654B1 (en) * 2003-06-27 2004-11-09 Dimitry Grabbe Fiber array ferrule and method of making
US8308066B2 (en) * 2003-12-22 2012-11-13 The Regents Of The University Of California Method for forming optically encoded thin films and particles with grey scale spectra
AU2004308380A1 (en) * 2003-12-22 2005-07-14 The Regents Of The University Of California Optically encoded particles, system and high-throughput screening
US7547424B2 (en) 2004-09-21 2009-06-16 Van Andel Research Institute Method and apparatus for making partitioned slides
CN100562750C (zh) * 2005-02-05 2009-11-25 北京源德生物医学工程有限公司 一种搭载试剂盒的传送机构
US20070108465A1 (en) * 2005-03-10 2007-05-17 The Regents Of The University Of California Porous microstructure multi layer spectroscopy and biosensing
US20060246576A1 (en) 2005-04-06 2006-11-02 Affymetrix, Inc. Fluidic system and method for processing biological microarrays in personal instrumentation
EP3257949A1 (de) 2005-06-15 2017-12-20 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten
US8492098B2 (en) * 2006-02-21 2013-07-23 The Trustees Of Tufts College Methods and arrays for target analyte detection and determination of reaction components that affect a reaction
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
US9976192B2 (en) 2006-03-10 2018-05-22 Ldip, Llc Waveguide-based detection system with scanning light source
US7951583B2 (en) * 2006-03-10 2011-05-31 Plc Diagnostics, Inc. Optical scanning system
US9423397B2 (en) 2006-03-10 2016-08-23 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
US8288157B2 (en) * 2007-09-12 2012-10-16 Plc Diagnostics, Inc. Waveguide-based optical scanning systems
US9528939B2 (en) 2006-03-10 2016-12-27 Indx Lifecare, Inc. Waveguide-based optical scanning systems
US20080003667A1 (en) * 2006-05-19 2008-01-03 Affymetrix, Inc. Consumable elements for use with fluid processing and detection systems
EP4170042A1 (de) 2006-06-14 2023-04-26 Verinata Health, Inc. Verfahren zur diagnose fötaler anomalien
EP4108780A1 (de) 2006-06-14 2022-12-28 Verinata Health, Inc. Analyse seltener zellen mittels probentrennung und dna-etiketten
EP2589668A1 (de) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse seltener Zellen mittels Probentrennung und DNA-Etiketten
NZ573915A (en) 2006-06-28 2011-11-25 Univ Swinburne Bead immobilization method involving casting a casting material over the casting surface to form a reverse casting
JP2010508858A (ja) 2006-11-15 2010-03-25 ザ ユニバーシティ オブ ブリティッシュ コロンビア アントラサイクリン誘発性の心毒性を予測する多型性
EP2395113A1 (de) 2007-06-29 2011-12-14 Population Genetics Technologies Ltd. Verfahren und Zusammensetzungen zur Isolierung von Nukleinsäuresequenzvarianten
EP2201374B1 (de) 2007-08-30 2015-10-07 Trustees Of Tufts College Verfahren zur bestimmung der konzentration eines analyten in lösung
DK2215209T3 (en) 2007-10-30 2018-09-03 Complete Genomics Inc DEVICE FOR HIGH-THROUGHPUT SEQUENCE OF NUCLEIC ACIDS
US9551026B2 (en) 2007-12-03 2017-01-24 Complete Genomincs, Inc. Method for nucleic acid detection using voltage enhancement
KR20100106456A (ko) * 2007-12-06 2010-10-01 코닌클리케 필립스 일렉트로닉스 엔.브이. 광학 면플레이트 및 그 제조 방법
US20090181390A1 (en) * 2008-01-11 2009-07-16 Signosis, Inc. A California Corporation High throughput detection of micrornas and use for disease diagnosis
JP4950336B2 (ja) * 2008-05-29 2012-06-13 東洋鋼鈑株式会社 生体関連分子の相互作用を検出するための方法及びユニット
GB2461026B (en) * 2008-06-16 2011-03-09 Plc Diagnostics Inc System and method for nucleic acids sequencing by phased synthesis
US8568659B2 (en) * 2008-09-11 2013-10-29 Mabgen, Llc Fiber optic device
US8222047B2 (en) * 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
WO2010127001A1 (en) * 2009-04-29 2010-11-04 Plc Diagnostics Inc. Waveguide-based detection system with scanning light source
DK2496720T3 (da) 2009-11-06 2020-09-28 Univ Leland Stanford Junior Ikke-invasiv diagnose af transplantatafstødning i organ-transplanterede patienter
EP2539717B1 (de) * 2010-02-22 2019-07-24 PerkinElmer Health Sciences, Inc. Mikroplattenhalterungssystem und messverfahren
US9110025B2 (en) 2010-03-01 2015-08-18 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) * 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
US8774494B2 (en) 2010-04-30 2014-07-08 Complete Genomics, Inc. Method and system for accurate alignment and registration of array for DNA sequencing
US9880089B2 (en) 2010-08-31 2018-01-30 Complete Genomics, Inc. High-density devices with synchronous tracks for quad-cell based alignment correction
US9671344B2 (en) 2010-08-31 2017-06-06 Complete Genomics, Inc. High-density biochemical array chips with asynchronous tracks for alignment correction by moiré averaging
WO2012051476A1 (en) 2010-10-15 2012-04-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Mid-infrared imaging of microarrays
EP2463661B1 (de) 2010-11-15 2014-01-08 F. Hoffmann-La Roche AG Instrument und Verfahren zur automatisierten Wärmebehandlung von Flüssigkeitsproben
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
WO2012142301A2 (en) 2011-04-12 2012-10-18 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patients recovery from a brain injury
EP2525211B1 (de) 2011-05-16 2018-01-03 F. Hoffmann-La Roche AG Instrument und verfahren zum detektieren von analyten
WO2013033073A1 (en) 2011-08-31 2013-03-07 Ventana Medical Systems, Inc. Expression of ets related gene (erg) and phosphatase and tensin homolog (pten) correlates with prostate cancer capsular penetration
CA2849771A1 (en) 2011-09-22 2013-03-28 ImmuMetrix, LLC Compositions and methods for analyzing heterogeneous samples
US10837879B2 (en) 2011-11-02 2020-11-17 Complete Genomics, Inc. Treatment for stabilizing nucleic acid arrays
US9803239B2 (en) 2012-03-29 2017-10-31 Complete Genomics, Inc. Flow cells for high density array chips
US9488823B2 (en) 2012-06-07 2016-11-08 Complete Genomics, Inc. Techniques for scanned illumination
US9628676B2 (en) 2012-06-07 2017-04-18 Complete Genomics, Inc. Imaging systems with movable scan mirrors
WO2014113502A1 (en) 2013-01-15 2014-07-24 Quanterix Corporation Detection of dna or rna using single molecule arrays and other techniques
CA2905517C (en) 2013-03-15 2024-11-12 Lineage Biosciences, Inc. METHODS AND COMPOSITIONS FOR LABELING AND ANALYZING SAMPLES
DE102013210204A1 (de) * 2013-05-31 2014-12-18 Gilupi Gmbh Detektionsvorrichtung zur in vivo und/oder in vitro Anreicherung von Probenmaterial
ES2911684T3 (es) 2014-02-21 2022-05-20 Harvard College Diseño de novo de proteínas alostéricas
US10018566B2 (en) 2014-02-28 2018-07-10 Ldip, Llc Partially encapsulated waveguide based sensing chips, systems and methods of use
US10119964B2 (en) * 2014-12-22 2018-11-06 Digital Biotech, LLC Multiplex assay strip, beads, device and method
WO2016138427A1 (en) 2015-02-27 2016-09-01 Indx Lifecare, Inc. Waveguide-based detection system with scanning light source
HUE071446T2 (hu) 2017-01-04 2025-09-28 Mgi Tech Co Ltd Lépésenkénti szekvenálás nem jelölt reverzibilis terminátorokkal vagy természetes nukleotidokkal
GB201700936D0 (en) * 2017-01-19 2017-03-08 Univ Bath Optical fibre apparatus and method
US10379297B2 (en) * 2017-04-21 2019-08-13 Intuitive Surgical Operations, Inc. Sealing a fiber bundle end with glass fritting
CN112236450B (zh) 2018-03-26 2025-07-22 广州呈源生物免疫技术有限公司 靶结合部分的组合物及使用方法
CN115427586B (zh) 2020-03-18 2025-03-28 深圳华大智造科技股份有限公司 大规模平行测序中的恢复阶段
US20250235872A1 (en) * 2022-04-29 2025-07-24 Singular Genomics Systems, Inc. Microplate carrier

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853658A (en) * 1971-07-12 1974-12-10 R Ney Fiber optical image magnifier panel and method of manufacture
US4046454A (en) * 1976-05-18 1977-09-06 Bell Telephone Laboratories, Incorporated Optical fiber connector
DE2740376C3 (de) * 1977-09-08 1980-06-04 Fa. A. Raymond, 7850 Loerrach Elastische Klemmhalterung für Rundstäbe mit variablen Durchmessern
US5206568A (en) 1986-03-26 1993-04-27 Beckman Instruments, Inc. Coordinated control of stepper motors
US4744627A (en) * 1986-11-03 1988-05-17 General Electric Company Optical fiber holder
US4973128A (en) * 1989-05-01 1990-11-27 Hodges Marvin P High gain optical fiber viewing device
JP3105624B2 (ja) * 1992-03-30 2000-11-06 日本碍子株式会社 多心コネクタおよびその製造法
US5589351A (en) 1994-12-06 1996-12-31 Nps Pharmaceuticals, Inc. Fluorescence detection apparatus
GB2315130B (en) 1996-07-10 2001-05-09 Cambridge Imaging Ltd Improved imaging system for fluorescence assays
GB2315131B (en) * 1996-07-10 2000-11-29 Cambridge Imaging Ltd Improvements in and relating to imaging
US6043880A (en) * 1997-09-15 2000-03-28 Becton Dickinson And Company Automated optical reader for nucleic acid assays
JP3813730B2 (ja) * 1998-03-19 2006-08-23 浜松ホトニクス株式会社 蛍光測定装置

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DE60030436T2 (de) 2007-03-29
DE60030436D1 (de) 2006-10-12
EP1190233B1 (de) 2006-08-30
AU779835B2 (en) 2005-02-10
WO2000071992A1 (en) 2000-11-30
EP1190233A1 (de) 2002-03-27
CA2374596A1 (en) 2000-11-30
US6396995B1 (en) 2002-05-28

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