ATE336T1 - STABILIZED PLATELET FACTOR 4 IMMUNASSAY CALIBRATION SOLUTIONS AND RADIOIMMUNASSAY METHODS. - Google Patents
STABILIZED PLATELET FACTOR 4 IMMUNASSAY CALIBRATION SOLUTIONS AND RADIOIMMUNASSAY METHODS.Info
- Publication number
- ATE336T1 ATE336T1 AT79300880T AT79300880T ATE336T1 AT E336 T1 ATE336 T1 AT E336T1 AT 79300880 T AT79300880 T AT 79300880T AT 79300880 T AT79300880 T AT 79300880T AT E336 T1 ATE336 T1 AT E336T1
- Authority
- AT
- Austria
- Prior art keywords
- platelet factor
- immunassay
- radioimmunassay
- methods
- stabilized
- Prior art date
Links
- 102000004211 Platelet factor 4 Human genes 0.000 title abstract 4
- 108090000778 Platelet factor 4 Proteins 0.000 title abstract 4
- 239000012482 calibration solution Substances 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 229960002897 heparin Drugs 0.000 abstract 1
- 229920000669 heparin Polymers 0.000 abstract 1
- 238000003018 immunoassay Methods 0.000 abstract 1
- 210000002381 plasma Anatomy 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
Abstract
The present invention encompasses a stabilized platelet factor4 immunoassay standard comprising an aqueous solution containing 10 to 100ng/ml of platelet factor 4, carrier protein, and an effective stabilizing amount of heparin, as well as <sup>125</sup>llabeled platelet factor 4 reagent stabilized in the same manner. These reagents are useful for testing blood plasma for activation of the coagulation system.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/922,135 US4195072A (en) | 1978-07-05 | 1978-07-05 | Stabilized platelet factor 4 immunoassay standards |
| EP79300880A EP0007163B1 (en) | 1978-07-05 | 1979-05-18 | Stabilized platelet factor 4 immunoassay standards and radio-immunoassay method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE336T1 true ATE336T1 (en) | 1981-11-15 |
Family
ID=25446555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT79300880T ATE336T1 (en) | 1978-07-05 | 1979-05-18 | STABILIZED PLATELET FACTOR 4 IMMUNASSAY CALIBRATION SOLUTIONS AND RADIOIMMUNASSAY METHODS. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4195072A (en) |
| EP (1) | EP0007163B1 (en) |
| JP (1) | JPS5928865B2 (en) |
| AT (1) | ATE336T1 (en) |
| AU (1) | AU525406B2 (en) |
| CA (1) | CA1116078A (en) |
| DE (1) | DE2961056D1 (en) |
| ES (1) | ES482215A1 (en) |
| ZA (1) | ZA792524B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2903701C2 (en) * | 1979-01-31 | 1980-10-16 | Boehringer Mannheim Gmbh, 6800 Mannheim | Control reagent for the determination of the heparin activity |
| US4311482A (en) * | 1979-10-09 | 1982-01-19 | Abbott Laboratories | Method and apparatus for collecting blood samples |
| DE3019612A1 (en) * | 1980-05-22 | 1981-11-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | STABILIZED THROMBINE PREPARATION |
| FR2585836B1 (en) * | 1985-08-02 | 1987-11-27 | Commissariat Energie Atomique | HOMOGENEOUS METHOD FOR LUMINESCENCE DETECTION AND / OR DETERMINATION OF AN ANALYTE IN A MEDIUM CONTAINING IT |
| US5166078A (en) * | 1986-08-19 | 1992-11-24 | Idexx Laboratories, Inc. | Hapten-macromolecule conjugates useful in hapten assays |
| AU639457B2 (en) * | 1989-06-02 | 1993-07-29 | Abbott Laboratories | Hiv p24 quantitation panel |
| US5599558A (en) * | 1989-09-15 | 1997-02-04 | Curative Technologies, Inc. | Selecting amounts of platelet releasate for efficacious treatment of tissue |
| IL95641A0 (en) * | 1989-09-15 | 1991-06-30 | Curative Tech Inc | Preparation of a platelet releasate product |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3960492A (en) * | 1974-05-31 | 1976-06-01 | Nuclear Diagnostics, Inc. | Method for determining an index of binding protein content of blood |
| US4105650A (en) * | 1975-04-11 | 1978-08-08 | Edward Shanbrom, Inc. | Method of preserving blood plasma i |
| US3985618A (en) * | 1975-05-02 | 1976-10-12 | Irving Innerfield | Method for detection of thrombosis and prethrombosis |
| DE2601372C3 (en) * | 1976-01-15 | 1980-03-27 | Behringwerke Ag, 3550 Marburg | Method for the determination of antithrombin III |
| US4097238A (en) * | 1977-06-03 | 1978-06-27 | Ashley Sheldon J | Method of analyzing blood plasma clotting |
-
1978
- 1978-07-05 US US05/922,135 patent/US4195072A/en not_active Expired - Lifetime
-
1979
- 1979-05-18 EP EP79300880A patent/EP0007163B1/en not_active Expired
- 1979-05-18 DE DE7979300880T patent/DE2961056D1/en not_active Expired
- 1979-05-18 AT AT79300880T patent/ATE336T1/en not_active IP Right Cessation
- 1979-05-23 ZA ZA792524A patent/ZA792524B/en unknown
- 1979-05-23 CA CA328,170A patent/CA1116078A/en not_active Expired
- 1979-05-24 AU AU47389/79A patent/AU525406B2/en not_active Expired
- 1979-06-21 JP JP54077589A patent/JPS5928865B2/en not_active Expired
- 1979-07-04 ES ES482215A patent/ES482215A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES482215A1 (en) | 1980-08-16 |
| EP0007163A1 (en) | 1980-01-23 |
| JPS5510598A (en) | 1980-01-25 |
| CA1116078A (en) | 1982-01-12 |
| AU4738979A (en) | 1980-01-31 |
| JPS5928865B2 (en) | 1984-07-16 |
| DE2961056D1 (en) | 1981-12-24 |
| EP0007163B1 (en) | 1981-10-21 |
| AU525406B2 (en) | 1982-11-04 |
| US4195072A (en) | 1980-03-25 |
| ZA792524B (en) | 1980-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |