ATE313T1 - ANTIGEN PREPARATION USABLE FOR VACCINE OR AS AN INTERMEDIATE THEREOR AND PROCESS FOR ITS MANUFACTURE. - Google Patents

ANTIGEN PREPARATION USABLE FOR VACCINE OR AS AN INTERMEDIATE THEREOR AND PROCESS FOR ITS MANUFACTURE.

Info

Publication number
ATE313T1
ATE313T1 AT79101777T AT79101777T ATE313T1 AT E313 T1 ATE313 T1 AT E313T1 AT 79101777 T AT79101777 T AT 79101777T AT 79101777 T AT79101777 T AT 79101777T AT E313 T1 ATE313 T1 AT E313T1
Authority
AT
Austria
Prior art keywords
vaccine
thereor
manufacture
antigen preparation
preparation usable
Prior art date
Application number
AT79101777T
Other languages
German (de)
Inventor
Alfred Mayer Prince
John Andrew Vnek
Original Assignee
New York Blood Center, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York Blood Center, Inc. filed Critical New York Blood Center, Inc.
Application granted granted Critical
Publication of ATE313T1 publication Critical patent/ATE313T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10161—Methods of inactivation or attenuation
    • C12N2730/10162—Methods of inactivation or attenuation by genetic engineering

Abstract

An antigenic composition, useful as a vaccine or vaccine intermediate, comprising a subparticulate mass containing hepatitis B surface and hepatitis B e antigens which have a particle size less than 20 nm, especially less than 5 nm, is obtained by contacting an antigenic mass containing particles of HBsAg of a particle size of at least 20 nm with a detergent followed by treating the detergent-containing antigenic composition with an aqueous aldehyde solution.
AT79101777T 1978-06-07 1979-06-06 ANTIGEN PREPARATION USABLE FOR VACCINE OR AS AN INTERMEDIATE THEREOR AND PROCESS FOR ITS MANUFACTURE. ATE313T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91342278A 1978-06-07 1978-06-07
EP79101777A EP0005864B1 (en) 1978-06-07 1979-06-06 Antigenic composition useful as a vaccine or vaccine intermediate, and process for preparing same

Publications (1)

Publication Number Publication Date
ATE313T1 true ATE313T1 (en) 1981-11-15

Family

ID=25433258

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101777T ATE313T1 (en) 1978-06-07 1979-06-06 ANTIGEN PREPARATION USABLE FOR VACCINE OR AS AN INTERMEDIATE THEREOR AND PROCESS FOR ITS MANUFACTURE.

Country Status (8)

Country Link
EP (1) EP0005864B1 (en)
JP (1) JPS54160716A (en)
AT (1) ATE313T1 (en)
AU (1) AU530195B2 (en)
CA (1) CA1117010A (en)
DE (1) DE2961060D1 (en)
MX (1) MX6290E (en)
ZA (1) ZA792485B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297355B1 (en) 1978-12-22 2001-10-02 Biogen, Inc. Polypeptides displaying HBV antigenicity or hbv antigen specificity
JPH0625069B2 (en) * 1981-01-29 1994-04-06 ブリティッシュ・テクノロジー・グループ・リミテッド Method for producing hepatitis B vaccine
AU8746582A (en) * 1981-09-02 1983-03-10 Biogen N.V. Hepatitis b virus e type antigen
GB8321789D0 (en) * 1983-08-12 1983-09-14 Biogen Nv Vaccines and compositions against hepatitis
WO1985004103A1 (en) * 1984-03-09 1985-09-26 Scripps Clinic And Research Foundation Synthetic hepatitis b virus vaccine including both t cell anc b cell determinants
JPS60197629A (en) * 1984-03-16 1985-10-07 Chemo Sero Therapeut Res Inst Method of purification of hbs antigen
CA2096650A1 (en) * 1991-09-18 1993-03-21 Keith E. Langley Hepatitis b vaccine formulation incorporating a bile acid salt

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1012445B (en) * 1973-05-21 1977-03-10 Siderurgie Fse Inst Rech PROCEDURE FOR THE DISSULFURING OF MOLTEN METALS
JPS5714653B2 (en) * 1974-06-21 1982-03-25
SE437329B (en) * 1975-03-14 1985-02-25 Community Blood Council PUT OUT OF BLOOD SERUM TO PROVIDE VACCIN AGAINST VIRUS Hepatitis
US4017360A (en) * 1975-05-14 1977-04-12 Merck & Co., Inc. Method for purifying hepatitis B antigen
GB1518582A (en) * 1975-11-17 1978-07-19 Community Blood Council Viral hepatitis vaccine
JPS53104724A (en) * 1977-02-23 1978-09-12 Green Cross Corp:The Preparation of uniform hbsag particles

Also Published As

Publication number Publication date
EP0005864A1 (en) 1979-12-12
MX6290E (en) 1985-03-18
CA1117010A (en) 1982-01-26
JPS54160716A (en) 1979-12-19
AU4767179A (en) 1979-12-13
EP0005864B1 (en) 1981-10-21
ZA792485B (en) 1980-06-25
DE2961060D1 (en) 1981-12-24
AU530195B2 (en) 1983-07-07

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee