ATE308325T1 - TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRION DERIVATIVES AS METALLOPROTEINASE INHIBITORS - Google Patents
TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRION DERIVATIVES AS METALLOPROTEINASE INHIBITORSInfo
- Publication number
- ATE308325T1 ATE308325T1 AT03712588T AT03712588T ATE308325T1 AT E308325 T1 ATE308325 T1 AT E308325T1 AT 03712588 T AT03712588 T AT 03712588T AT 03712588 T AT03712588 T AT 03712588T AT E308325 T1 ATE308325 T1 AT E308325T1
- Authority
- AT
- Austria
- Prior art keywords
- trion
- triaryl
- aryloxy
- pyrimidine
- oxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37599002P | 2002-04-26 | 2002-04-26 | |
| PCT/IB2003/001560 WO2003090752A1 (en) | 2002-04-26 | 2003-04-15 | Triaryl-oxy-aryloxy-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE308325T1 true ATE308325T1 (en) | 2005-11-15 |
Family
ID=29270744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03712588T ATE308325T1 (en) | 2002-04-26 | 2003-04-15 | TRIARYL-OXY-ARYLOXY-PYRIMIDINE-2,4,6-TRION DERIVATIVES AS METALLOPROTEINASE INHIBITORS |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7119201B2 (en) |
| EP (1) | EP1501515B1 (en) |
| JP (1) | JP2005529132A (en) |
| AR (1) | AR039658A1 (en) |
| AT (1) | ATE308325T1 (en) |
| AU (1) | AU2003216677A1 (en) |
| BR (1) | BR0309386A (en) |
| CA (1) | CA2484067A1 (en) |
| DE (1) | DE60302149T2 (en) |
| DO (1) | DOP2003000621A (en) |
| ES (1) | ES2250880T3 (en) |
| GT (1) | GT200300082A (en) |
| MX (1) | MXPA04009392A (en) |
| NI (1) | NI200300045A (en) |
| PA (1) | PA8571501A1 (en) |
| TW (1) | TW200403998A (en) |
| UY (1) | UY27772A1 (en) |
| WO (1) | WO2003090752A1 (en) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005529889A (en) * | 2002-04-26 | 2005-10-06 | ファイザー・プロダクツ・インク | Pyrimidine-2,4,6-trione metallo-proteinase inhibitor |
| MXPA04008563A (en) | 2002-04-26 | 2004-12-06 | Pfizer Prod Inc | Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors. |
| MXPA04010545A (en) * | 2002-04-26 | 2005-01-25 | Pfizer Prod Inc | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors. |
| NI200300045A (en) | 2002-04-26 | 2005-07-08 | Pfizer Prod Inc | INHIBITORS OF TRIARILOXIARILOXIPIRIMIDIN-2,4,6-METALOPROTEINASE TRION. |
| ATE493973T1 (en) | 2004-06-04 | 2011-01-15 | Teva Pharma | PHARMACEUTICAL COMPOSITION CONTAINING IRBESARTAN |
| AU2005287170B2 (en) * | 2004-09-17 | 2012-03-29 | Exelixis, Inc | Pyrazole kinase modulators and methods of use |
| WO2009082398A1 (en) | 2007-12-21 | 2009-07-02 | University Of Notre Dame Du Lac | Antibacterial compounds and methods of using same |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| GB201115937D0 (en) | 2011-09-14 | 2011-10-26 | Univ Aberdeen | 18F-labelled compounds for use as positron emission imaging agents |
| WO2015123003A1 (en) | 2014-02-14 | 2015-08-20 | Warrell Raymond P | Bifunctional compounds and use for reducing uric acid levels |
| US10600505B2 (en) | 2014-02-21 | 2020-03-24 | Medicomp Systems, Inc. | Intelligent prompting of protocols |
| JP2017533187A (en) | 2014-09-25 | 2017-11-09 | ユニヴァーシティー オブ ノートル ダム デュ ラック | Non-β-lactam antibiotics |
| EP3247704A4 (en) | 2015-01-22 | 2018-10-03 | Acquist LLC | Bifunctional compounds and use for reducing uric acid levels |
| TWI772309B (en) | 2016-06-30 | 2022-08-01 | 美商艾克奎斯特有限責任公司 | Compounds and their use for reducing uric acid levels |
| EP3481819B1 (en) | 2016-07-06 | 2022-06-01 | Acquist LLC | Compounds and their use for reducing uric acid levels |
| US11168062B2 (en) | 2016-09-12 | 2021-11-09 | University Of Notre Dame Du Lac | Compounds for the treatment of Clostridium difficile infection |
| MX2020004283A (en) | 2017-10-27 | 2021-10-21 | Boehringer Ingelheim Int | Pyridine carbonyl derivatives and therapeutic uses thereof as trpc6 inhibitors. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| DE19548624A1 (en) * | 1995-12-23 | 1997-06-26 | Boehringer Mannheim Gmbh | New barbituric acid derivatives, processes for their preparation and medicaments containing these compounds |
| ES2247707T3 (en) * | 1997-06-21 | 2006-03-01 | Roche Diagnostics Gmbh | DERIVATIVES OF BARBITURIC ACID WITH ANTIMETASTASIC AND ANTITUMORAL ACTIVITY |
| US6265578B1 (en) * | 1999-02-12 | 2001-07-24 | Hoffmann-La Roche Inc. | Pyrimidine-2,4,6-triones |
| HN2000000137A (en) * | 1999-08-12 | 2001-02-02 | Pfizer Prod Inc | PYRIMIDINE-2,4,6-METALOPROTEINASE INHIBITING TRIONES |
| US6841671B2 (en) | 2000-10-26 | 2005-01-11 | Pfizer Inc. | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
| MXPA03003734A (en) | 2000-10-26 | 2003-07-28 | Pfizer Prod Inc | Pyrimidine-2,4,6-trione metalloproteinase inhibitors. |
| MXPA04008563A (en) | 2002-04-26 | 2004-12-06 | Pfizer Prod Inc | Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors. |
| MXPA04010545A (en) | 2002-04-26 | 2005-01-25 | Pfizer Prod Inc | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors. |
| NI200300045A (en) | 2002-04-26 | 2005-07-08 | Pfizer Prod Inc | INHIBITORS OF TRIARILOXIARILOXIPIRIMIDIN-2,4,6-METALOPROTEINASE TRION. |
-
2003
- 2003-03-07 NI NI200300045A patent/NI200300045A/en unknown
- 2003-04-01 DO DO2003000621A patent/DOP2003000621A/en unknown
- 2003-04-10 GT GT200300082A patent/GT200300082A/en unknown
- 2003-04-15 JP JP2003587386A patent/JP2005529132A/en active Pending
- 2003-04-15 BR BR0309386-7A patent/BR0309386A/en not_active IP Right Cessation
- 2003-04-15 ES ES03712588T patent/ES2250880T3/en not_active Expired - Lifetime
- 2003-04-15 WO PCT/IB2003/001560 patent/WO2003090752A1/en active IP Right Grant
- 2003-04-15 DE DE60302149T patent/DE60302149T2/en not_active Expired - Fee Related
- 2003-04-15 MX MXPA04009392A patent/MXPA04009392A/en unknown
- 2003-04-15 EP EP03712588A patent/EP1501515B1/en not_active Expired - Lifetime
- 2003-04-15 CA CA002484067A patent/CA2484067A1/en not_active Abandoned
- 2003-04-15 AU AU2003216677A patent/AU2003216677A1/en not_active Abandoned
- 2003-04-15 AT AT03712588T patent/ATE308325T1/en not_active IP Right Cessation
- 2003-04-22 PA PA20038571501A patent/PA8571501A1/en unknown
- 2003-04-23 UY UY27772A patent/UY27772A1/en not_active Application Discontinuation
- 2003-04-24 AR ARP030101419A patent/AR039658A1/en unknown
- 2003-04-25 TW TW092109776A patent/TW200403998A/en unknown
- 2003-04-28 US US10/424,614 patent/US7119201B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2250880T3 (en) | 2006-04-16 |
| PA8571501A1 (en) | 2003-12-10 |
| TW200403998A (en) | 2004-03-16 |
| CA2484067A1 (en) | 2003-11-06 |
| BR0309386A (en) | 2005-02-22 |
| WO2003090752A1 (en) | 2003-11-06 |
| AU2003216677A1 (en) | 2003-11-10 |
| US20040006057A1 (en) | 2004-01-08 |
| EP1501515B1 (en) | 2005-11-02 |
| NI200300045A (en) | 2005-07-08 |
| DE60302149T2 (en) | 2006-07-20 |
| DOP2003000621A (en) | 2003-10-31 |
| AR039658A1 (en) | 2005-03-02 |
| JP2005529132A (en) | 2005-09-29 |
| DE60302149D1 (en) | 2005-12-08 |
| GT200300082A (en) | 2004-04-19 |
| MXPA04009392A (en) | 2005-01-25 |
| EP1501515A1 (en) | 2005-02-02 |
| US7119201B2 (en) | 2006-10-10 |
| UY27772A1 (en) | 2003-11-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |