ATE299948T1 - Tripeptidylpeptidase-inhibitoren - Google Patents
Tripeptidylpeptidase-inhibitorenInfo
- Publication number
- ATE299948T1 ATE299948T1 AT96916181T AT96916181T ATE299948T1 AT E299948 T1 ATE299948 T1 AT E299948T1 AT 96916181 T AT96916181 T AT 96916181T AT 96916181 T AT96916181 T AT 96916181T AT E299948 T1 ATE299948 T1 AT E299948T1
- Authority
- AT
- Austria
- Prior art keywords
- tripeptidylpeptidase
- inhibitors
- formulawherein
- cholecystokinin
- hydrates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/595—Gastrins; Cholecystokinins [CCK]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9505489A FR2733995B1 (fr) | 1995-05-09 | 1995-05-09 | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
PCT/FR1996/000700 WO1996035805A2 (fr) | 1995-05-09 | 1996-05-09 | Inhibiteurs de tripeptidylpeptidases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE299948T1 true ATE299948T1 (de) | 2005-08-15 |
Family
ID=9478806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96916181T ATE299948T1 (de) | 1995-05-09 | 1996-05-09 | Tripeptidylpeptidase-inhibitoren |
Country Status (11)
Country | Link |
---|---|
US (2) | US6403561B1 (de) |
EP (1) | EP0828851B1 (de) |
JP (1) | JPH11510684A (de) |
AT (1) | ATE299948T1 (de) |
CA (1) | CA2221035A1 (de) |
DE (1) | DE69634955T2 (de) |
DK (1) | DK0828851T3 (de) |
ES (1) | ES2244969T3 (de) |
FR (1) | FR2733995B1 (de) |
PT (1) | PT828851E (de) |
WO (1) | WO1996035805A2 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2733995B1 (fr) * | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
WO1999033801A1 (en) * | 1997-12-23 | 1999-07-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Tripeptidyl peptidase inhibitors |
EP1147214B1 (de) | 1999-01-13 | 2011-01-05 | The Research Foundation Of State University Of New York | Neues verfahren zum erschaffen von proteinkinase-inhibitoren |
WO2001081306A2 (en) * | 2000-04-19 | 2001-11-01 | Eli Lilly And Company | Azide cyclization-based synthesis and intermediates for spla2 inhibitors |
SK6282003A3 (en) | 2000-10-30 | 2004-02-03 | Janssen Pharmaceutica Nv | Tripeptidyl peptidase inhibitors |
WO2003035621A1 (en) * | 2001-10-22 | 2003-05-01 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors, methods for designing them, and methods of using them |
US7005445B2 (en) | 2001-10-22 | 2006-02-28 | The Research Foundation Of State University Of New York | Protein kinase and phosphatase inhibitors and methods for designing them |
US20030165574A1 (en) * | 2002-03-01 | 2003-09-04 | Ward Loren Spencer | Compositions and methods for treatment of body weight conditions |
US20040097422A1 (en) * | 2002-06-14 | 2004-05-20 | Karl Munger | Methods of use for tripeptidyl peptidase II inhibitors as anticancer agents |
US7838542B2 (en) | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
US9403768B2 (en) | 2012-10-11 | 2016-08-02 | Hoffmann-La Roche Inc. | Indolines |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH626872A5 (de) * | 1976-06-21 | 1981-12-15 | Hoffmann La Roche | |
PH14141A (en) * | 1976-06-25 | 1981-03-05 | Hoffmann La Roche | Pharmaceutical composition containing dipeptide derivatives |
HU180925B (en) * | 1979-06-28 | 1983-05-30 | Richter Gedeon Vegyeszet | Process for producing tripeptide-amides trh-analogues,effectives on the central nerve systhem |
CS226907B1 (en) * | 1981-08-07 | 1984-04-16 | Kasafirek Evzen | Alkylamides of carboxyalkanoylpeptides |
AT389517B (de) * | 1987-10-08 | 1989-12-27 | Hoechst Ag | Chromophore peptide, verfahren zu ihrer herstellung und ihre verwendung zum nachweis der peptidylglycin-alpha-amidierenden monooxygenase |
US5159060A (en) * | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
ATE349461T1 (de) * | 1991-10-22 | 2007-01-15 | New England Medical Center Inc | Inhibitoren der dipeptidyl-aminopeptidase vom typ iv |
FR2733995B1 (fr) * | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
-
1995
- 1995-05-09 FR FR9505489A patent/FR2733995B1/fr not_active Expired - Fee Related
-
1996
- 1996-05-09 US US08/930,055 patent/US6403561B1/en not_active Expired - Fee Related
- 1996-05-09 AT AT96916181T patent/ATE299948T1/de not_active IP Right Cessation
- 1996-05-09 DE DE69634955T patent/DE69634955T2/de not_active Expired - Fee Related
- 1996-05-09 DK DK96916181T patent/DK0828851T3/da active
- 1996-05-09 EP EP96916181A patent/EP0828851B1/de not_active Expired - Lifetime
- 1996-05-09 JP JP8533833A patent/JPH11510684A/ja not_active Ceased
- 1996-05-09 PT PT96916181T patent/PT828851E/pt unknown
- 1996-05-09 WO PCT/FR1996/000700 patent/WO1996035805A2/fr active IP Right Grant
- 1996-05-09 ES ES96916181T patent/ES2244969T3/es not_active Expired - Lifetime
- 1996-05-09 CA CA002221035A patent/CA2221035A1/fr not_active Abandoned
-
2001
- 2001-09-25 US US09/962,298 patent/US20030027743A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0828851A2 (de) | 1998-03-18 |
CA2221035A1 (fr) | 1996-11-14 |
EP0828851B1 (de) | 2005-07-20 |
ES2244969T3 (es) | 2005-12-16 |
US6403561B1 (en) | 2002-06-11 |
DE69634955T2 (de) | 2006-05-24 |
DE69634955D1 (de) | 2005-08-25 |
JPH11510684A (ja) | 1999-09-21 |
PT828851E (pt) | 2005-11-30 |
DK0828851T3 (da) | 2005-10-24 |
WO1996035805A2 (fr) | 1996-11-14 |
FR2733995B1 (fr) | 1997-07-25 |
WO1996035805A3 (fr) | 1997-01-30 |
US20030027743A1 (en) | 2003-02-06 |
FR2733995A1 (fr) | 1996-11-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 0828851 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |