ATE295T1 - Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen. - Google Patents

Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen.

Info

Publication number
ATE295T1
ATE295T1 AT79101668T AT79101668T ATE295T1 AT E295 T1 ATE295 T1 AT E295T1 AT 79101668 T AT79101668 T AT 79101668T AT 79101668 T AT79101668 T AT 79101668T AT E295 T1 ATE295 T1 AT E295T1
Authority
AT
Austria
Prior art keywords
derivatives
vitamin
radioimmune
testing
processes
Prior art date
Application number
AT79101668T
Other languages
English (en)
Inventor
Jack Bernstein
Ravi K. Varma
Berthold R. Vogt
Frank L. Weisenborn
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Application granted granted Critical
Publication of ATE295T1 publication Critical patent/ATE295T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/367—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
AT79101668T 1978-05-30 1979-05-30 Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen. ATE295T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/910,568 US4209614A (en) 1978-05-30 1978-05-30 Vitamin B12 derivative suitable for radiolabeling
EP79101668A EP0005834B1 (de) 1978-05-30 1979-05-30 Vitamin B12 Derivate, Verfahren zu deren Herstellung und ihre Verwendung bei Radioimmun-Testen

Publications (1)

Publication Number Publication Date
ATE295T1 true ATE295T1 (de) 1981-10-15

Family

ID=25428998

Family Applications (1)

Application Number Title Priority Date Filing Date
AT79101668T ATE295T1 (de) 1978-05-30 1979-05-30 Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen.

Country Status (9)

Country Link
US (1) US4209614A (de)
EP (1) EP0005834B1 (de)
JP (1) JPS54157600A (de)
AT (1) ATE295T1 (de)
AU (1) AU4649179A (de)
CA (1) CA1109464A (de)
DE (1) DE2960982D1 (de)
IL (1) IL57385A0 (de)
ZA (1) ZA792064B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2437398A1 (fr) * 1978-06-20 1980-04-25 Commissariat Energie Atomique Compose iode utilisable comme traceur en radio-immunologie
US4355018A (en) * 1980-05-21 1982-10-19 Hoffmann-La Roche Inc. Assay for vitamin B12
EP0069450B1 (de) * 1981-06-22 1985-04-10 TECHNICON INSTRUMENTS CORPORATION (a New York corporation) Markierte Vitamin-B12-Derivate, ihre Herstellung und Verwendung
US4465776A (en) * 1982-09-27 1984-08-14 Research Corporation Monoclonal antibodies to vitamin B6 and immunoassay method
NZ217821A (en) * 1985-10-10 1989-07-27 Biotech Australia Pty Ltd Oral delivery system; complex of active agent and vitamin b12 or analogue thereof
US5807832A (en) * 1987-06-09 1998-09-15 Biotech Australia Pty Limited Oral delivery of biologically active substances bound to vitamin B12
NZ242220A (en) * 1991-04-02 1994-04-27 Biotech Australia Pty Ltd Complex for oral delivery of a substance to the circulatory or lymphatic drainage system comprising microparticle coupled to at least one carrier, the substance being encapsulated by the microparticle
JPH06336494A (ja) * 1993-05-27 1994-12-06 Nippon Oil Co Ltd 疎水性ビタミンｂ１２誘導体
US5739313A (en) * 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
AUPP405098A0 (en) * 1998-06-12 1998-07-02 Access Pharmaceuticals Australia Pty Limited Novel methods of preparation of vitamin b12 derivatives suitable for conjugation to pharmaceuticals
US6806363B1 (en) * 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
US7591995B2 (en) * 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
EP1231942A1 (de) * 1999-10-15 2002-08-21 Mayo Foundation For Medical Education And Research Kobalamin-konjugate anwendbar wie bilderzeugungsmitteln und wie antikrebsmitteln
MXPA02003772A (es) 1999-10-15 2005-04-28 Mayo Foundation Conjugados de cobalamina, utiles como agentes para obtencion de imagen y como agentes terapeuticos.
CA2427146A1 (en) * 2000-10-25 2002-07-18 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
EP1754712A3 (de) * 2000-10-25 2009-01-14 Mayo Foundation For Medical Education And Research Transcobalamin-bindende Konjugate zur Behandlung abnormaler zellulärer Proliferation
AU2002322275A1 (en) * 2001-06-20 2003-01-08 Mayo Foundation For Medical Education And Research Adenosyl-cobalamin fortified compositions
US20060074034A1 (en) * 2001-09-17 2006-04-06 Collins Douglas A Cobalamin mediated delivery of nucleic acids, analogs and derivatives thereof
US20030144198A1 (en) * 2001-09-28 2003-07-31 Collins Douglas A. Coadministration of transport protein with conjugated cobalamin to deliver agents
KR100440725B1 (ko) * 2002-06-20 2004-07-15 주식회사 그린진 바이오텍 비생물성 스트레스에 대한 단자엽 식물의 내성을증가시키는 방법
CN1902214A (zh) * 2003-12-22 2007-01-24 索里达哥股份有限公司 用于诊断和治疗异常细胞增殖的钴胺素衍生物
CN101222853B (zh) * 2005-05-17 2012-07-18 卡吉尔公司 粒状卵磷脂、粒状溶血卵磷脂、它们的生产方法和包含它们的组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR5372M (de) * 1966-02-10 1967-10-16
US3981863A (en) * 1975-02-25 1976-09-21 Micromedic Diagonistics, Inc. Cyanocobalamin derivatives
CA1118409A (en) * 1977-08-12 1982-02-16 Jack Bernstein Steroid derivatives and their use in radioimmunoassays

Also Published As

Publication number Publication date
EP0005834A1 (de) 1979-12-12
CA1109464A (en) 1981-09-22
JPS54157600A (en) 1979-12-12
US4209614A (en) 1980-06-24
IL57385A0 (en) 1979-09-30
EP0005834B1 (de) 1981-10-14
DE2960982D1 (en) 1981-12-24
AU4649179A (en) 1979-12-06
ZA792064B (en) 1980-05-28

Similar Documents

Publication Publication Date Title
ATE295T1 (de) Vitamin b12 derivate, verfahren zu deren herstellung und ihre verwendung bei radioimmun-testen.
ES517919A0 (es) Procedimiento para la preparacion de derivados de (2-halogeno-ergolinil)-n',n'-dietilurea.
ES478156A1 (es) Un metodo de preparacion de compuestos heterociclicos derivados de hidantoina.
ES470745A1 (es) Un procedimiento para preparar derivados de 6,6'-oxibis-pi- rona halo-sustituida
NO854677L (no) Fremgangsmaate for fremstilling av 5-alkyl-1-fenyl-2-piperazinoalkylpyrazolin-3-on-forbindelser.
SE8700328D0 (sv) Amine derivatives, processes for their production and their use
ATE31414T1 (de) 8-substituierte pyrrolizidin-derivate und deren verwendung.
DE3860300D1 (de) Tieftemperaturschmieroel.
SE7713704L (sv) Propionsyraderivat och sett for framstellning av desamma
GB2002385A (en) Steroid hemiesters and their use in radioimmunoassays
KR830005225A (ko) 데오필린의 피페라진 유도체의 제조방법
SE7812371L (sv) Forfarande for framstellning av fenoxialkanolaminderivat
GB2003480A (en) Digoxigenin derivatives
ATE617T1 (de) Steroidderivate, verfahren zu ihrer herstellung und ihre anwendung bei radioimmunoassays.
ATE17851T1 (de) Imidazolylkarbonsaeure, deren derivate und herstellung.
SE8302084D0 (sv) New benzimidazole derivatives
ATE222T1 (de) Bis-(2,4-dinitrophenyl)-m ethyl-pyridinium-verbindungen, verfahren zu ihrer herstellung und ihre verwendung als ph-indikatoren.
ES381927A1 (es) Procedimiento para la obtencion de esteres de amidas de a- cido tiofosforico.
SE7901316L (sv) Derivat av dehydrocykliciminsyror
ES482948A1 (es) Un procedimiento para la preparacion de derivados de oxadia-zolotriazona
KR830005181A (ko) 아세트 아닐리드 유도체의 제조방법
ES460297A1 (es) Un compuesto.
ES8104218A1 (es) Un procedimiento para la preparacion de una sal de un acido alquilen-bis-ditiocarbamico
JPS52116432A (en) Preparation of 3-alkoxybenzanilides
ES483299A1 (es) Un procedimiento para la preparacion de derivados de benzo- diacepina

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties