ATE285750T1 - USE OF TESTOSTERONE ESTERS AND/OR TESTOSTERONE FOR THE PRODUCTION OF BUCCALLY APPLICABLE BIOADHASIVE SYSTEMS WITH TIME-CONTROLLED MEDICINAL EFFECT - Google Patents

USE OF TESTOSTERONE ESTERS AND/OR TESTOSTERONE FOR THE PRODUCTION OF BUCCALLY APPLICABLE BIOADHASIVE SYSTEMS WITH TIME-CONTROLLED MEDICINAL EFFECT

Info

Publication number
ATE285750T1
ATE285750T1 AT99950580T AT99950580T ATE285750T1 AT E285750 T1 ATE285750 T1 AT E285750T1 AT 99950580 T AT99950580 T AT 99950580T AT 99950580 T AT99950580 T AT 99950580T AT E285750 T1 ATE285750 T1 AT E285750T1
Authority
AT
Austria
Prior art keywords
testosterone
time
systems
bioadhasive
esters
Prior art date
Application number
AT99950580T
Other languages
German (de)
Inventor
Doris Huebler
Guenter Kaufmann
Michael Oettel
Holger Zimmermann
Michael Dittgen
Sabine Fricke
Manfred Boese
Ralf Ladwig
Sven Claussen
Carsten Timpe
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority claimed from PCT/EP1999/007254 external-priority patent/WO2000019975A1/en
Application granted granted Critical
Publication of ATE285750T1 publication Critical patent/ATE285750T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

The use of testosterone esters with 1-20C carboxylic acids (or their mixtures with other such esters and/or testosterone) is claimed in the preparation of buccally applied bioadhesive systems for time-controlled active agent release in the treatment of diseases associated with variations of testosterone levels.
AT99950580T 1998-10-02 1999-09-30 USE OF TESTOSTERONE ESTERS AND/OR TESTOSTERONE FOR THE PRODUCTION OF BUCCALLY APPLICABLE BIOADHASIVE SYSTEMS WITH TIME-CONTROLLED MEDICINAL EFFECT ATE285750T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19847252A DE19847252B4 (en) 1998-10-02 1998-10-02 Buccally applicable bioadhesive systems with time-controlled release of active ingredient containing testosterone esters and optionally additional testosterone
PCT/EP1999/007254 WO2000019975A1 (en) 1998-10-02 1999-09-30 Use of testosterone esters and/or testosterone for producing bucally applicable bio-adhesive systems with time-released active ingredients

Publications (1)

Publication Number Publication Date
ATE285750T1 true ATE285750T1 (en) 2005-01-15

Family

ID=7884375

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99950580T ATE285750T1 (en) 1998-10-02 1999-09-30 USE OF TESTOSTERONE ESTERS AND/OR TESTOSTERONE FOR THE PRODUCTION OF BUCCALLY APPLICABLE BIOADHASIVE SYSTEMS WITH TIME-CONTROLLED MEDICINAL EFFECT

Country Status (3)

Country Link
AT (1) ATE285750T1 (en)
DE (2) DE19847252B4 (en)
ES (1) ES2235523T3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004043434A1 (en) * 2002-11-14 2004-05-27 Shear/Kershman Laboratories, Inc. Oral testosterone delivery system with improved sustained release
DE102005015128B4 (en) * 2005-03-31 2008-12-11 Bayer Schering Pharma Aktiengesellschaft Wafers containing steroid hormones

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4396615A (en) * 1981-06-24 1983-08-02 Duke University Method of treating androgen-related disorders
GB8403360D0 (en) * 1984-02-08 1984-03-14 Erba Farmitalia Pharmaceutical compositions
EP0452334A4 (en) * 1989-10-31 1991-12-11 Watson Laboratoires, Inc. Mucoadhesive carrier for delivery of therapeutical agent
EP0800385B1 (en) * 1994-09-30 2000-12-20 Takeda Chemical Industries, Ltd. Oral sustained-release preparation
AUPM855194A0 (en) * 1994-10-04 1994-10-27 Csl Limited Controlled-release pharmaceutical preparations

Also Published As

Publication number Publication date
DE19847252A1 (en) 2000-04-13
DE59911381D1 (en) 2005-02-03
ES2235523T3 (en) 2005-07-01
DE19847252B4 (en) 2004-02-12

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Legal Events

Date Code Title Description
REN Ceased due to non-payment of the annual fee