ATE283260T1 - 1-(1-subst.-4-piperidinyl)methyl)-4-piperidin- derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellung - Google Patents
1-(1-subst.-4-piperidinyl)methyl)-4-piperidin- derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellungInfo
- Publication number
- ATE283260T1 ATE283260T1 AT99913701T AT99913701T ATE283260T1 AT E283260 T1 ATE283260 T1 AT E283260T1 AT 99913701 T AT99913701 T AT 99913701T AT 99913701 T AT99913701 T AT 99913701T AT E283260 T1 ATE283260 T1 AT E283260T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- subst
- piperidinyl
- intermediates
- methyl
- Prior art date
Links
- 239000000543 intermediate Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13450498 | 1998-04-28 | ||
| JP19501998 | 1998-06-24 | ||
| PCT/JP1999/002056 WO1999055674A1 (fr) | 1998-04-28 | 1999-04-19 | Derives de 1-[(1-substituee-4-piperidinyle)methyle]-4-piperidine, procede de production de ceux-ci, compositions medicinales contenant ces composes et intermediaires de ces composes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283260T1 true ATE283260T1 (de) | 2004-12-15 |
Family
ID=26468607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99913701T ATE283260T1 (de) | 1998-04-28 | 1999-04-19 | 1-(1-subst.-4-piperidinyl)methyl)-4-piperidin- derivate, verafhren zu deren herstellung, pharmazeutische mixturen und intermediate zu deren herstellung |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US6294555B1 (de) |
| EP (1) | EP1076055B1 (de) |
| KR (1) | KR20010043032A (de) |
| CN (1) | CN1118452C (de) |
| AR (1) | AR019115A1 (de) |
| AT (1) | ATE283260T1 (de) |
| AU (1) | AU746406B2 (de) |
| BR (1) | BR9909991A (de) |
| CA (1) | CA2330475A1 (de) |
| DE (1) | DE69922186T2 (de) |
| ES (1) | ES2234248T3 (de) |
| HK (1) | HK1031869A1 (de) |
| HU (1) | HUP0101511A3 (de) |
| ID (1) | ID26399A (de) |
| IL (1) | IL138568A0 (de) |
| NO (1) | NO318451B1 (de) |
| NZ (1) | NZ507119A (de) |
| PL (1) | PL343726A1 (de) |
| PT (1) | PT1076055E (de) |
| RU (1) | RU2214400C2 (de) |
| SK (1) | SK15852000A3 (de) |
| TW (1) | TWI242004B (de) |
| WO (1) | WO1999055674A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6344358B1 (en) * | 1999-05-28 | 2002-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Agent for expression of long-term potentiation of synaptic transmission comprising compound having brain somatostatin activation property |
| IL159256A0 (en) | 2001-07-02 | 2004-06-01 | Astrazeneca Ab | Piperidine derivatives useful as modulators of chemokine receptor activity |
| GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
| GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
| SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| SE0200843D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
| US6696468B2 (en) | 2002-05-16 | 2004-02-24 | Dainippon Pharmaceutical Co., Ltd. | (s)-4-amino-5-chloro-2-methoxy-n-[1-[1-(2-tetrahydrofuryl-carbonyl)-4-piperidinylmethyl]-4-piperidinyl]benzamide, process for the preparation thereof, pharmaceutical composition containing the same, and intermediate therefor |
| SE0202838D0 (sv) * | 2002-09-24 | 2002-09-24 | Astrazeneca Ab | Chemical compounds |
| SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
| TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
| US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
| US20050267141A1 (en) * | 2004-05-28 | 2005-12-01 | Phytogen Life Sciences Inc. | Process to prepare camptothecin derivatives |
| EP1807423B1 (de) * | 2004-11-05 | 2009-05-20 | Theravance, Inc. | Chinolinon-carboxamid-verbindungen |
| DE602005016446D1 (de) * | 2004-11-05 | 2009-10-15 | Theravance Inc | 5-HT4-Rezeptoragonistenverbindungen |
| WO2006069125A1 (en) * | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
| US7446114B2 (en) * | 2005-03-02 | 2008-11-04 | Theravance, Inc. | Quinolinone compounds as 5-HT4 receptor agonists |
| US7256294B2 (en) * | 2005-05-25 | 2007-08-14 | Theravance, Inc. | Crystalline form of a benzimidazole-carboxamide medicinal compound |
| MY147756A (en) | 2005-05-25 | 2013-01-15 | Theravance Inc | Benzimidazole-carboxamide compounds as 5-ht4 receptor agonists |
| CA2615650A1 (en) | 2005-07-21 | 2007-01-25 | Astrazeneca Ab | Novel piperidine derivatives |
| TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
| US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
| US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
| EP2496228B1 (de) | 2009-11-06 | 2014-01-15 | SK Biopharmaceuticals Co., Ltd. | Verfahren zur behandlung von aufmerksamkeitsdefizitstörung mit hyperaktivität |
| CA2779442A1 (en) | 2009-11-06 | 2011-05-12 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating fibromyalgia syndrome |
| US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
| US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
| US9187451B2 (en) | 2011-11-18 | 2015-11-17 | Heptares Therapeutics Limited | Muscarinic M1 receptor agonists |
| WO2017137910A1 (en) * | 2016-02-11 | 2017-08-17 | Symed Labs Limited | Processes for the preparation of highly pure prucalopride succinate and its intermediates |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| CN110950843B (zh) * | 2019-11-28 | 2022-12-27 | 广东东阳光药业有限公司 | 取代的苯酰胺衍生物及其用途 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9005014D0 (en) | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
| GB9204565D0 (en) | 1992-03-03 | 1992-04-15 | Smithkline Beecham Plc | Pharmaceuticals |
| US5864039A (en) | 1994-03-30 | 1999-01-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and use thereof as medicaments |
| EP0823423B1 (de) * | 1995-04-28 | 2004-06-16 | Banyu Pharmaceutical Co., Ltd. | 1,4-disubstituierte piperidinderivate |
| JPH111472A (ja) * | 1996-04-30 | 1999-01-06 | Dainippon Pharmaceut Co Ltd | ベンズアミド誘導体及びそれを含有する医薬組成物 |
-
1999
- 1999-04-19 ES ES99913701T patent/ES2234248T3/es not_active Expired - Lifetime
- 1999-04-19 DE DE69922186T patent/DE69922186T2/de not_active Expired - Fee Related
- 1999-04-19 IL IL13856899A patent/IL138568A0/xx unknown
- 1999-04-19 EP EP99913701A patent/EP1076055B1/de not_active Expired - Lifetime
- 1999-04-19 AT AT99913701T patent/ATE283260T1/de not_active IP Right Cessation
- 1999-04-19 ID IDW20002107A patent/ID26399A/id unknown
- 1999-04-19 BR BR9909991-8A patent/BR9909991A/pt not_active IP Right Cessation
- 1999-04-19 CN CN99805583A patent/CN1118452C/zh not_active Expired - Fee Related
- 1999-04-19 RU RU2000129161/04A patent/RU2214400C2/ru not_active IP Right Cessation
- 1999-04-19 PT PT99913701T patent/PT1076055E/pt unknown
- 1999-04-19 NZ NZ507119A patent/NZ507119A/xx unknown
- 1999-04-19 CA CA002330475A patent/CA2330475A1/en not_active Abandoned
- 1999-04-19 HU HU0101511A patent/HUP0101511A3/hu unknown
- 1999-04-19 KR KR1020007011894A patent/KR20010043032A/ko not_active Application Discontinuation
- 1999-04-19 WO PCT/JP1999/002056 patent/WO1999055674A1/ja not_active Application Discontinuation
- 1999-04-19 SK SK1585-2000A patent/SK15852000A3/sk unknown
- 1999-04-19 PL PL99343726A patent/PL343726A1/xx unknown
- 1999-04-19 US US09/674,162 patent/US6294555B1/en not_active Expired - Fee Related
- 1999-04-19 AU AU31716/99A patent/AU746406B2/en not_active Ceased
- 1999-04-19 TW TW088106200A patent/TWI242004B/zh active
- 1999-04-28 AR ARP990101966A patent/AR019115A1/es unknown
-
2000
- 2000-10-27 NO NO20005430A patent/NO318451B1/no unknown
-
2001
- 2001-03-28 HK HK01102252A patent/HK1031869A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20010043032A (ko) | 2001-05-25 |
| NZ507119A (en) | 2002-08-28 |
| BR9909991A (pt) | 2000-12-26 |
| NO20005430D0 (no) | 2000-10-27 |
| SK15852000A3 (sk) | 2001-06-11 |
| PL343726A1 (en) | 2001-09-10 |
| EP1076055B1 (de) | 2004-11-24 |
| NO20005430L (no) | 2000-12-20 |
| DE69922186D1 (de) | 2004-12-30 |
| CN1118452C (zh) | 2003-08-20 |
| ES2234248T3 (es) | 2005-06-16 |
| EP1076055A1 (de) | 2001-02-14 |
| EP1076055A4 (de) | 2001-07-18 |
| HUP0101511A2 (hu) | 2001-09-28 |
| HUP0101511A3 (en) | 2002-12-28 |
| CN1298391A (zh) | 2001-06-06 |
| AR019115A1 (es) | 2001-12-26 |
| US6294555B1 (en) | 2001-09-25 |
| TWI242004B (en) | 2005-10-21 |
| IL138568A0 (en) | 2001-10-31 |
| CA2330475A1 (en) | 1999-11-04 |
| AU3171699A (en) | 1999-11-16 |
| DE69922186T2 (de) | 2005-05-04 |
| ID26399A (id) | 2000-12-21 |
| AU746406B2 (en) | 2002-05-02 |
| NO318451B1 (no) | 2005-03-21 |
| WO1999055674A1 (fr) | 1999-11-04 |
| HK1031869A1 (en) | 2001-06-29 |
| RU2214400C2 (ru) | 2003-10-20 |
| PT1076055E (pt) | 2005-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1076055 Country of ref document: EP |
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| REN | Ceased due to non-payment of the annual fee |