ATE277907T1 - BLOOD SUGAR LOWERING AND LIPID LOWERING COMPOUNDS - Google Patents

BLOOD SUGAR LOWERING AND LIPID LOWERING COMPOUNDS

Info

Publication number
ATE277907T1
ATE277907T1 AT97931523T AT97931523T ATE277907T1 AT E277907 T1 ATE277907 T1 AT E277907T1 AT 97931523 T AT97931523 T AT 97931523T AT 97931523 T AT97931523 T AT 97931523T AT E277907 T1 ATE277907 T1 AT E277907T1
Authority
AT
Austria
Prior art keywords
lowering
compounds
blood sugar
lipid
lipid lowering
Prior art date
Application number
AT97931523T
Other languages
German (de)
Inventor
Samuel J Dominianni
William H Gritton
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE277907T1 publication Critical patent/ATE277907T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

This invention provides 1,2,3,4-tetrahydroisoquinoline compounds and their pharmaceuticallyacceptable salts, pharmaceutical formulations of said compounds, and methods for treating hyperglycemia associated with non-insulin dependent diabetes and for treating hyperlipidemia.
AT97931523T 1996-07-01 1997-06-30 BLOOD SUGAR LOWERING AND LIPID LOWERING COMPOUNDS ATE277907T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2101796P 1996-07-01 1996-07-01
PCT/US1997/011514 WO1998000403A1 (en) 1996-07-01 1997-06-30 Hypoglycemic and hypolipidemic compounds

Publications (1)

Publication Number Publication Date
ATE277907T1 true ATE277907T1 (en) 2004-10-15

Family

ID=21801860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97931523T ATE277907T1 (en) 1996-07-01 1997-06-30 BLOOD SUGAR LOWERING AND LIPID LOWERING COMPOUNDS

Country Status (10)

Country Link
US (1) US6121282A (en)
EP (1) EP1019378B1 (en)
JP (1) JP2000515501A (en)
AT (1) ATE277907T1 (en)
AU (1) AU3513497A (en)
CA (1) CA2259431A1 (en)
DE (1) DE69731003D1 (en)
IL (1) IL121203A (en)
WO (1) WO1998000403A1 (en)
ZA (1) ZA975867B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414002B1 (en) 1999-09-22 2002-07-02 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
TWI260321B (en) 1999-09-22 2006-08-21 Bristol Myers Squibb Co Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
RU2256661C2 (en) 1999-12-03 2005-07-20 Киото Фармасьютикал Индастриз, Лтд. Derivatives of tetrahydroisoquinoline and their salts and pharmaceutical composition based on thereof
US7187947B1 (en) 2000-03-28 2007-03-06 Affinity Labs, Llc System and method for communicating selected information to an electronic device
US6872732B2 (en) * 2001-05-29 2005-03-29 Kyoto Pharmaceutical Industries, Ltd. Heterocyclic derivatives and medicinal use thereof
HUP0401862A3 (en) 2001-05-29 2009-03-30 Kyoto Pharmaceutical Ind Novel heterocyclic compound and medicinal use thereof and pharmaceutical compositions containing them
ATE394376T1 (en) * 2001-06-18 2008-05-15 Ono Pharmaceutical Co TETRAHYDROCHINOLINE DERIVATIVE COMPOUND AND THE COMPOUND AS AN ACTIVE MEDICINAL PRODUCT
US7548875B2 (en) 2001-06-27 2009-06-16 John Mikkelsen Media delivery platform
US6716842B2 (en) 2002-04-05 2004-04-06 Warner-Lambert Company, Llc Antidiabetic agents
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004106276A1 (en) 2003-05-30 2004-12-09 Takeda Pharmaceutical Company Limited Condensed ring compound
JP4805552B2 (en) * 2003-05-30 2011-11-02 武田薬品工業株式会社 Fused ring compounds
EP1716137A1 (en) 2004-02-04 2006-11-02 Pfizer Products Incorporated Substituted quinoline compounds
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
WO2012033195A1 (en) * 2010-09-10 2012-03-15 京都薬品工業株式会社 Heterocyclic compound

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988720A (en) * 1985-05-28 1991-01-29 Beecham Group P.L.C. Novel treatment of hyperglycaemia
US4999363A (en) * 1988-06-09 1991-03-12 Kyowa Hakko Kogyo Co., Ltd. Tricyclic compounds
US4902695A (en) * 1989-02-13 1990-02-20 Eli Lilly And Company Excitatory amino acid receptor antagonists
AU6368090A (en) * 1989-10-03 1991-04-11 Warner-Lambert Company Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity
US5036079A (en) * 1989-12-07 1991-07-30 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
EP0543018B1 (en) * 1991-06-07 1996-01-10 Otsuka Pharmaceutical Co., Ltd. Antidiabetic agent
US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
PT604657E (en) * 1992-05-21 2000-04-28 Otsuka Pharma Co Ltd DERIVED FROM PHOSPHONIC DIESTER
US5236934A (en) * 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
JP2845743B2 (en) * 1992-12-28 1999-01-13 三菱化学株式会社 New naphthalene derivatives
GB9311661D0 (en) * 1993-06-05 1993-07-21 Smithkline Beecham Plc Novel compounds
US5591862A (en) * 1993-06-11 1997-01-07 Takeda Chemical Industries, Ltd. Tetrazole derivatives, their production and use
CA2172125A1 (en) * 1993-09-30 1995-04-06 S. Jane Desolms Inhibitors of farnesyl-protein transferase
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
US5616819A (en) * 1995-08-28 1997-04-01 Laroche Industries Inc. Process for preparing fluorinated aliphatic compounds
US5885327A (en) * 1995-09-12 1999-03-23 Henkel Corporation Process for the recovery of gold
DE19535243A1 (en) * 1995-09-22 1997-03-27 Bayer Ag New intermediates for the synthesis of bisphosphine compounds

Also Published As

Publication number Publication date
JP2000515501A (en) 2000-11-21
EP1019378A1 (en) 2000-07-19
DE69731003D1 (en) 2004-11-04
EP1019378B1 (en) 2004-09-29
CA2259431A1 (en) 1998-01-08
WO1998000403A1 (en) 1998-01-08
EP1019378A4 (en) 2001-09-26
ZA975867B (en) 1999-01-04
AU3513497A (en) 1998-01-21
IL121203A (en) 2001-04-30
US6121282A (en) 2000-09-19
IL121203A0 (en) 1997-11-20

Similar Documents

Publication Publication Date Title
ATE277907T1 (en) BLOOD SUGAR LOWERING AND LIPID LOWERING COMPOUNDS
HUP9800523A2 (en) Insulin derivatives
DZ2887A1 (en) Azetidine derivatives, their preparation and the drugs containing them.
NZ236002A (en) Transdermal delivery system for 2-amino-6-n-propylamino-4,5,6,7-tetrahydrobenzothiazole
DK0941103T3 (en) Pharmaceutical preparation for the treatment of diabetes
DK233586D0 (en) 5-SUBSTITUTED 1,3-THIAZOLIDON-2,4-DION COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE
MX9203808A (en) HIGH DRUG CONTENT FORMULATIONS: LIPID, FROM LIPOSOMIC-ANTINEOPLASTIC AGENTS.
NO20006630D0 (en) Pharmaceutical composition for the treatment of diabetes
SE9702457D0 (en) screening
DK0777483T3 (en) Methods and means of drug administration
EE200000535A (en) Use of trisubstituted 1,3,5-triazine derivatives for the preparation of a medicament for the treatment of HIV infection, a compound, a pharmaceutical composition containing it, a process for the preparation of a compound and a composition, and
RU94022479A (en) Use of antiestrogenic compounds and pharmaceutically acceptable salts and solvents for blood glucose concentration decrease, pharmaceutical preparation
FI972308A (en) 2-Substituted 1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions containing them and methods for their use
DE68913762D1 (en) Diaryl compounds as antiatherosclerotic agents.
CY1105463T1 (en) CONTROLLED ADMINISTRATION OF ANTI-ADPHILISTICS
DK88087D0 (en) TRICYCLIC 5- (3-CHLOR-6-METHYL-5,5-DIOXO-6,11-DIHYDRO-DIBENZO- (C, F) - (1,2) -THIAZEPIN-11-YL) -AMINO-PENTANIC ACID DERIVATIVE, PROCEDURE FOR PREPARING THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
ES2171233T3 (en) USE OF ELIPRODIL FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF ISCHEMICAL DISORDERS OF THE RETINA OR THE OPTICAL NERVE.
DE69626544T2 (en) DRUG SUBSTANCES
ES2043719T3 (en) DRUG ADMINISTRATION BY VIA PERCUTANEA.
FR2704857B1 (en) New substituted benzodioxins, process for their preparation and pharmaceutical compositions containing them.
PT869785E (en) 4-HYDROXYCUMARIN-3-CARBOXAMIDES FOR THE TREATMENT OF DIABETES MELLITUS NOT INSULINODEPENDENT
SE9000207L (en) MEDICINAL PRODUCTS AND THE USE OF THE SAME
BR9813098A (en) Use of glycosaminoglycans, pharmaceutical preparation, and combination
MX9704035A (en) Substituted 2-(phosphinyloxymethyl)-1,2,5-thiadiazolidin-3-one 1,1-dioxides and compositions and method of use thereof.
WO2000054760A3 (en) Bicyclo (3.3.1) nonenes useful for the treatment of diabetes and hypertriglyceridemia

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties