ATE267171T1 - Phenylsulphonylderivative als 5-ht rezeptorliganden - Google Patents

Phenylsulphonylderivative als 5-ht rezeptorliganden

Info

Publication number
ATE267171T1
ATE267171T1 AT00900723T AT00900723T ATE267171T1 AT E267171 T1 ATE267171 T1 AT E267171T1 AT 00900723 T AT00900723 T AT 00900723T AT 00900723 T AT00900723 T AT 00900723T AT E267171 T1 ATE267171 T1 AT E267171T1
Authority
AT
Austria
Prior art keywords
receptor ligands
phenyl sulphonyl
sulphonyl derivatives
derivatives
phenyl
Prior art date
Application number
AT00900723T
Other languages
English (en)
Inventor
Peter Blurton
Frank Burkamp
Susan Koon-Fung Cheng
Stephen Robert Terlin Fletcher
Angus Murray Macleod
Niel Monique Bodil Van
Daniel Spinks
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE267171T1 publication Critical patent/ATE267171T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00900723T 1999-01-19 2000-01-11 Phenylsulphonylderivative als 5-ht rezeptorliganden ATE267171T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9901147.0A GB9901147D0 (en) 1999-01-19 1999-01-19 Therapeutic agents
PCT/GB2000/000153 WO2000043362A1 (en) 1999-01-19 2000-01-11 Phenylsulphonyl derivatives as 5-ht receptor ligands

Publications (1)

Publication Number Publication Date
ATE267171T1 true ATE267171T1 (de) 2004-06-15

Family

ID=10846135

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900723T ATE267171T1 (de) 1999-01-19 2000-01-11 Phenylsulphonylderivative als 5-ht rezeptorliganden

Country Status (10)

Country Link
US (2) US6559166B1 (de)
EP (1) EP1147084B1 (de)
JP (1) JP2002535308A (de)
AT (1) ATE267171T1 (de)
AU (1) AU773296B2 (de)
CA (1) CA2359983A1 (de)
DE (1) DE60010855T2 (de)
ES (1) ES2219296T3 (de)
GB (1) GB9901147D0 (de)
WO (1) WO2000043362A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10000739A1 (de) * 2000-01-11 2001-07-12 Merck Patent Gmbh Piperidin- und Piperazinderivate
GB0007907D0 (en) * 2000-03-31 2000-05-17 Merck Sharp & Dohme Therapeutic agents
GB0311349D0 (en) * 2003-05-16 2003-06-25 Merck Sharp & Dohme Therapeutic agents, compositions, preparations and uses
GB0326221D0 (en) 2003-11-10 2003-12-17 Merck Sharp & Dohme Therapeutic agents,compositions,preparations and uses
GB0419192D0 (en) * 2004-08-27 2004-09-29 Merck Sharp & Dohme Therapeutic agents
GB0426313D0 (en) * 2004-12-01 2005-01-05 Merck Sharp & Dohme Therapeutic agents
GB0504828D0 (en) * 2005-03-09 2005-04-13 Merck Sharp & Dohme Therapeutic agents

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4128552A (en) 1977-09-26 1978-12-05 Warner-Lambert Company 1-[4,4-Bis(4-fluorophenyl)butyl]-4-phenylthio-1,2,3,6-tetrahydropyridines and related sulfoxides and sulfones
US4218455A (en) * 1978-07-10 1980-08-19 Warner-Lambert Company 1-(4-Fluorophenyl)-4-[1,2,3,6-tetrahydro-4-(phenylthio)-1-pyridinyl]-butanones and related sulfoxides and sulfones
AU593194B2 (en) 1986-09-26 1990-02-01 Sumitomo Pharmaceuticals Company, Limited Imide derivatives ,and their production and use
PH25458A (en) 1987-08-24 1991-07-01 Eisai Co Ltd Piperidine derivatives, therapeutic, preventive agents
US5162347A (en) 1987-08-24 1992-11-10 Eisai Co., Ltd. Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
US5246946A (en) 1987-08-24 1993-09-21 Eisai Co., Ltd. Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same
DK730588A (da) 1988-02-03 1989-08-04 Asta Pharma Ag Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel
US5272160A (en) * 1989-05-17 1993-12-21 Pfizer Inc 2-piperidino-1-alkanol derivatives as antiischemic agents
ATE114467T1 (de) 1990-06-01 1994-12-15 Merrell Dow Pharma (+)-alpha-(2,3 dimethoxyphenyl)-1-(2- (fluorophenyl)ethyl>-4-piperidinmethanol.
US5418242A (en) 1993-05-18 1995-05-23 Laboratoires Upsa Piperidinylthioindole derivatives, their methods of preparation and pharmaceutical compositions in which they are present, useful especially as analgesics
US5753679A (en) * 1995-05-10 1998-05-19 Hoffmann-La Roche Inc. Benzyl-piperidine derivatives
DE19601189A1 (de) * 1996-01-15 1997-07-17 Degussa Verfahren zur Herstellung von 1,2,4-Triazolin-3(2H)-onen
US6197791B1 (en) * 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
PL367487A1 (en) * 2001-05-11 2005-02-21 Pharmacia Corporation Aromatic sulfone hydroxamates and their use as protease inhibitors

Also Published As

Publication number Publication date
EP1147084A1 (de) 2001-10-24
WO2000043362A1 (en) 2000-07-27
CA2359983A1 (en) 2000-07-27
EP1147084B1 (de) 2004-05-19
AU773296B2 (en) 2004-05-20
JP2002535308A (ja) 2002-10-22
AU3064700A (en) 2000-08-07
GB9901147D0 (en) 1999-03-10
DE60010855D1 (de) 2004-06-24
ES2219296T3 (es) 2004-12-01
US6777430B2 (en) 2004-08-17
US6559166B1 (en) 2003-05-06
US20030203889A1 (en) 2003-10-30
DE60010855T2 (de) 2005-06-16

Similar Documents

Publication Publication Date Title
DE60203797D1 (de) Benzo[d]azepin-derivative als 5-ht6-rezeptor-antagonisten
BR0215042A (pt) fenil-naftalenos substituìdos como agentes estrogênicos
DE60021370D1 (de) Piperazinderivate verwendbar als ccr5 antagonisten
ATE302005T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
HUT75113A (en) 4-substituted piperidine derivatives useful as neurokinin antagonists
DE69616480D1 (de) Piperidinderivate als neurokininantagonisten
DE60021371D1 (de) Piperidinderivate verwendbar als ccr5 antagonisten
UY26082A1 (es) Derivados de 1,4-diazabiciclo [3.2.2] nonan-4-carboxilato y -carboxamidas, su preparacion y su aplicacion en terapeutica
ATE302606T1 (de) N-ureidoalkylpiperidine als modulatoren der aktivität der chemokinrezeptoren
GEP20074210B (en) Tropane derivatives as ccr5 modulators
ATE236877T1 (de) N-(indolcarbonyl-)piperazinderivate als 5-ht2a- rezeptor liganden
DE60318219D1 (de) PYRIMIDINDERIVATE ALS MODULATOREN DER AKTIVITuT VON CHEMOKINREZEPTOREN
DE69326650T2 (de) Piperidinderivate von Benzimidazole als antihistaminische und antiallergische Mittel
ES2185054T3 (es) Derivados de benzopirano.
BG104069A (en) 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1h-indole derivatives interacting with the dopamine d4 receptor
CA2376949A1 (en) Heterocyclic aminopyrrolidine derivatives as melatonergic agents
FI932173A0 (fi) 4-(1,2-benzisoxazolyl)piperidinantipsykotiska medel
ATE267171T1 (de) Phenylsulphonylderivative als 5-ht rezeptorliganden
ATE384708T1 (de) Piperazinderivate als aktivitätsmodulatoren der chemokinrezeptoren
DE69412073T2 (de) Xanthinderivate als adenosin-a1 rezeptor antagonisten
MXPA03003971A (es) Derivados de indol como inhibidores de pde5.
BR0016955A (pt) Derivados inovadores de indoles, seus compostos, sua composição farmacêutica seu uso e método de administração
ATE250584T1 (de) Synthese von 5- oder 8-bromoisoquinolin derivaten
DE69803689D1 (de) 8-azabicyclo(3.2.1)0ctan-3-methanaminderivate als liganden der dopamin-rezeptoren d2 und d3 und der serotonin-rezeptoren 5ht1a und 5ht2
DE69014903D1 (de) Disubstituierte piperidine und pyrrolidine als anticholinergische mittel.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties