ATE265537T1 - Kinase für die stellen-spezifische phosphorylierung von i-kappa-b-alpha - Google Patents
Kinase für die stellen-spezifische phosphorylierung von i-kappa-b-alphaInfo
- Publication number
- ATE265537T1 ATE265537T1 AT97916786T AT97916786T ATE265537T1 AT E265537 T1 ATE265537 T1 AT E265537T1 AT 97916786 T AT97916786 T AT 97916786T AT 97916786 T AT97916786 T AT 97916786T AT E265537 T1 ATE265537 T1 AT E265537T1
- Authority
- AT
- Austria
- Prior art keywords
- kinase
- relates
- site
- antibodies
- specific phosphorylation
- Prior art date
Links
- 108091000080 Phosphotransferase Proteins 0.000 title abstract 5
- 102000020233 phosphotransferase Human genes 0.000 title abstract 5
- 230000026731 phosphorylation Effects 0.000 title abstract 2
- 238000006366 phosphorylation reaction Methods 0.000 title abstract 2
- 102000018745 NF-KappaB Inhibitor alpha Human genes 0.000 title 1
- 108010052419 NF-KappaB Inhibitor alpha Proteins 0.000 title 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 3
- 108060006633 protein kinase Proteins 0.000 abstract 3
- 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 abstract 2
- 101710083073 NF-kappa-B inhibitor alpha Proteins 0.000 abstract 2
- 239000000556 agonist Substances 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 2
- 238000004166 bioassay Methods 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 210000004408 hybridoma Anatomy 0.000 abstract 1
- 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61649996A | 1996-03-19 | 1996-03-19 | |
PCT/US1997/004195 WO1997035014A1 (en) | 1996-03-19 | 1997-03-19 | A KINASE CAPABLE OF SITE-SPECIFIC PHOSPHORYLATION OF IλB$g(a) |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE265537T1 true ATE265537T1 (de) | 2004-05-15 |
Family
ID=24469728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97916786T ATE265537T1 (de) | 1996-03-19 | 1997-03-19 | Kinase für die stellen-spezifische phosphorylierung von i-kappa-b-alpha |
Country Status (11)
Country | Link |
---|---|
US (4) | US6107073A (de) |
EP (1) | EP0910645B1 (de) |
JP (1) | JP2000510328A (de) |
KR (1) | KR20000064670A (de) |
AT (1) | ATE265537T1 (de) |
AU (1) | AU728679C (de) |
BR (1) | BR9710408A (de) |
CA (1) | CA2249551A1 (de) |
DE (1) | DE69728880T2 (de) |
ES (1) | ES2217407T3 (de) |
WO (1) | WO1997035014A1 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5972674A (en) | 1996-08-26 | 1999-10-26 | Signal Pharmaceuticals, Inc. | Stimulus-inducible protein kinase complex and methods of use therefor |
WO1998008955A1 (en) * | 1996-08-26 | 1998-03-05 | Signal Pharmaceuticals, Inc. | Stimulus-inducible i (kappa)b kinase [ikk] signalsome |
WO1998035691A1 (en) | 1997-02-15 | 1998-08-20 | Proscript, Inc. | Treatment of infarcts through inhibition of nf-kappab |
US6030834A (en) * | 1997-12-30 | 2000-02-29 | Chiron Corporation | Human IKK-beta DNA constructs and cells |
AU3354499A (en) | 1998-03-16 | 1999-10-11 | Cadus Pharmaceutical Corporation | Human mekk proteins, corresponding nucleic acid molecules, and uses therefor |
US7024312B1 (en) | 1999-01-19 | 2006-04-04 | Maxygen, Inc. | Methods for making character strings, polynucleotides and polypeptides having desired characteristics |
US7062076B1 (en) * | 1999-08-27 | 2006-06-13 | Iris Biotechnologies, Inc. | Artificial intelligence system for genetic analysis |
US7430477B2 (en) | 1999-10-12 | 2008-09-30 | Maxygen, Inc. | Methods of populating data structures for use in evolutionary simulations |
US7018796B2 (en) * | 2000-04-07 | 2006-03-28 | Shionogi & Co., Ltd. | Preincubation assay methods |
US6818427B1 (en) | 2000-10-27 | 2004-11-16 | Millennium Pharmaceuticals, Inc. | MEKK1 molecules and uses thereof |
EP1488335A4 (de) | 2002-03-09 | 2006-11-15 | Maxygen Inc | Optimierung von crossover-punkten für die gerichtete evolution |
US7524664B2 (en) | 2003-06-17 | 2009-04-28 | California Institute Of Technology | Regio- and enantioselective alkane hydroxylation with modified cytochrome P450 |
US20070202593A1 (en) * | 2006-02-27 | 2007-08-30 | Research Development Foundation | Cell-Targeted IKB and Methods for the Use Thereof |
US8026085B2 (en) * | 2006-08-04 | 2011-09-27 | California Institute Of Technology | Methods and systems for selective fluorination of organic molecules |
US8252559B2 (en) * | 2006-08-04 | 2012-08-28 | The California Institute Of Technology | Methods and systems for selective fluorination of organic molecules |
WO2008121435A2 (en) * | 2007-02-02 | 2008-10-09 | The California Institute Of Technology | Methods for generating novel stabilized proteins |
US20080268517A1 (en) * | 2007-02-08 | 2008-10-30 | The California Institute Of Technology | Stable, functional chimeric cytochrome p450 holoenzymes |
US8802401B2 (en) * | 2007-06-18 | 2014-08-12 | The California Institute Of Technology | Methods and compositions for preparation of selectively protected carbohydrates |
WO2012135415A1 (en) * | 2011-03-29 | 2012-10-04 | Glaxosmithkline Llc | Buffer system for protein purification |
US9322007B2 (en) | 2011-07-22 | 2016-04-26 | The California Institute Of Technology | Stable fungal Cel6 enzyme variants |
CN107549099A (zh) * | 2017-08-30 | 2018-01-09 | 佛山市高明区新广农牧有限公司 | 一种禽白血病的净化方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4281061A (en) * | 1979-07-27 | 1981-07-28 | Syva Company | Double antibody for enhanced sensitivity in immunoassay |
CA1341288C (en) * | 1986-06-27 | 2001-09-04 | Yoshitaka Ono | Protein kinase c |
US5188964A (en) * | 1990-04-12 | 1993-02-23 | Board Of Regents, The University Of Texas System | Method and kit for the prognostication of breast cancer patient via heat shock/stress protein determination |
AU2140592A (en) | 1991-05-17 | 1992-12-30 | Chiron Corporation | Inhibitor of nf-kappa b transcriptional activator and uses thereof |
US5972674A (en) | 1996-08-26 | 1999-10-26 | Signal Pharmaceuticals, Inc. | Stimulus-inducible protein kinase complex and methods of use therefor |
WO1998008955A1 (en) | 1996-08-26 | 1998-03-05 | Signal Pharmaceuticals, Inc. | Stimulus-inducible i (kappa)b kinase [ikk] signalsome |
US6268194B1 (en) | 1997-02-25 | 2001-07-31 | The Regents Of The University Of California | IKB kinase and methods of using same |
WO1998037228A1 (en) | 1997-02-25 | 1998-08-27 | The Regents Of The University Of California | IλB KINASE, SUBUNITS THEREOF, AND METHODS OF USING SAME |
US6242253B1 (en) | 1997-10-09 | 2001-06-05 | Regents Of The University Of California | IkB kinase, subunits thereof, and methods of using same |
-
1997
- 1997-03-19 DE DE69728880T patent/DE69728880T2/de not_active Expired - Lifetime
- 1997-03-19 AU AU25317/97A patent/AU728679C/en not_active Ceased
- 1997-03-19 BR BR9710408A patent/BR9710408A/pt not_active IP Right Cessation
- 1997-03-19 WO PCT/US1997/004195 patent/WO1997035014A1/en active IP Right Grant
- 1997-03-19 US US08/825,559 patent/US6107073A/en not_active Expired - Lifetime
- 1997-03-19 AT AT97916786T patent/ATE265537T1/de not_active IP Right Cessation
- 1997-03-19 CA CA002249551A patent/CA2249551A1/en not_active Abandoned
- 1997-03-19 JP JP09533584A patent/JP2000510328A/ja active Pending
- 1997-03-19 ES ES97916786T patent/ES2217407T3/es not_active Expired - Lifetime
- 1997-03-19 KR KR1019980707386A patent/KR20000064670A/ko not_active Application Discontinuation
- 1997-03-19 EP EP97916786A patent/EP0910645B1/de not_active Expired - Lifetime
-
1999
- 1999-09-24 US US09/406,293 patent/US20020168740A1/en not_active Abandoned
-
2002
- 2002-01-17 US US10/052,005 patent/US6787346B2/en not_active Expired - Fee Related
-
2004
- 2004-03-25 US US10/810,793 patent/US7452977B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU2531797A (en) | 1997-10-10 |
KR20000064670A (ko) | 2000-11-06 |
US20020168740A1 (en) | 2002-11-14 |
AU728679B2 (en) | 2001-01-18 |
US6787346B2 (en) | 2004-09-07 |
DE69728880T2 (de) | 2005-04-28 |
EP0910645B1 (de) | 2004-04-28 |
WO1997035014A1 (en) | 1997-09-25 |
JP2000510328A (ja) | 2000-08-15 |
CA2249551A1 (en) | 1997-09-25 |
BR9710408A (pt) | 1999-08-17 |
US7452977B2 (en) | 2008-11-18 |
ES2217407T3 (es) | 2004-11-01 |
AU728679C (en) | 2002-03-21 |
US20020151022A1 (en) | 2002-10-17 |
EP0910645A1 (de) | 1999-04-28 |
US20040161814A1 (en) | 2004-08-19 |
DE69728880D1 (de) | 2004-06-03 |
US6107073A (en) | 2000-08-22 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |