ATE261987T1 - CYCLOALKYL INHIBITORS OF PROTEIN FARNESYL TRANSFERASE - Google Patents

CYCLOALKYL INHIBITORS OF PROTEIN FARNESYL TRANSFERASE

Info

Publication number
ATE261987T1
ATE261987T1 AT97954575T AT97954575T ATE261987T1 AT E261987 T1 ATE261987 T1 AT E261987T1 AT 97954575 T AT97954575 T AT 97954575T AT 97954575 T AT97954575 T AT 97954575T AT E261987 T1 ATE261987 T1 AT E261987T1
Authority
AT
Austria
Prior art keywords
farnesyl transferase
protein farnesyl
inhibitors
cycloalkyl
cycloalkyl inhibitors
Prior art date
Application number
AT97954575T
Other languages
German (de)
Inventor
Annette Marian Doherty
James Stanley Kaltenbronn
Daniele M Leonard
Namara Dennis Joseph Mc
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE261987T1 publication Critical patent/ATE261987T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06147—Dipeptides with the first amino acid being heterocyclic and His-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel inhibitors of protein farnesyltransferase enzymes are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer, restenosis, atherosclerosis, psoriasis and endometriosis.
AT97954575T 1996-12-17 1997-12-16 CYCLOALKYL INHIBITORS OF PROTEIN FARNESYL TRANSFERASE ATE261987T1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3366196P 1996-12-17 1996-12-17
US5683197P 1997-08-22 1997-08-22
PCT/US1997/023280 WO1998027109A1 (en) 1996-12-17 1997-12-16 Cycloalkyl inhibitors of protein farnesyltransferase

Publications (1)

Publication Number Publication Date
ATE261987T1 true ATE261987T1 (en) 2004-04-15

Family

ID=26709973

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97954575T ATE261987T1 (en) 1996-12-17 1997-12-16 CYCLOALKYL INHIBITORS OF PROTEIN FARNESYL TRANSFERASE

Country Status (21)

Country Link
US (1) US6281194B1 (en)
EP (1) EP0951471B1 (en)
JP (1) JP2001506265A (en)
KR (1) KR20000057601A (en)
AT (1) ATE261987T1 (en)
AU (1) AU721786C (en)
BR (1) BR9713744A (en)
CA (1) CA2264207A1 (en)
CO (1) CO4920227A1 (en)
DE (1) DE69728165T2 (en)
DK (1) DK0951471T3 (en)
ES (1) ES2216189T3 (en)
HR (1) HRP970693B1 (en)
ID (1) ID19142A (en)
IL (1) IL128546A0 (en)
NO (1) NO992933L (en)
NZ (1) NZ334702A (en)
PE (1) PE46999A1 (en)
PT (1) PT951471E (en)
TW (1) TW552259B (en)
WO (1) WO1998027109A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001506265A (en) 1996-12-17 2001-05-15 ワーナー−ランバート・コンパニー Cycloalkyl inhibitors of protein farnesyltransferase
PT1076663E (en) 1998-04-27 2004-06-30 Warner Lambert Co FUNCTIONALIZED ALKYL AND ALCENYL DERIVATIVES OF SIDE CHAIN OF GLYCINAMID AS FARNESIL TRANSFERASE INHIBITORS
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
AU2007229363B2 (en) * 2001-08-24 2009-06-04 University Of South Florida Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment
ES2335092T3 (en) * 2001-08-24 2010-03-22 Yale University PIPERAZINONA COMPOUNDS AS ANTITUMOR AND ANTICANCER AGENTS.
WO2005049589A2 (en) * 2003-10-14 2005-06-02 Cadila Healthcare Limited Heterocyclic compounds for the treatment of hyperlipidemia, diabetes, obesity and similar diseases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012612A1 (en) * 1993-11-05 1995-05-11 Warner-Lambert Company Substituted di- and tripeptide inhibitors of protein:farnesyl transferase
US5571792A (en) * 1994-06-30 1996-11-05 Warner-Lambert Company Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
JP2001506265A (en) 1996-12-17 2001-05-15 ワーナー−ランバート・コンパニー Cycloalkyl inhibitors of protein farnesyltransferase

Also Published As

Publication number Publication date
DE69728165D1 (en) 2004-04-22
CO4920227A1 (en) 2000-05-29
NO992933D0 (en) 1999-06-16
HRP970693B1 (en) 2002-06-30
IL128546A0 (en) 2000-01-31
DK0951471T3 (en) 2004-07-19
WO1998027109A1 (en) 1998-06-25
BR9713744A (en) 2000-03-21
KR20000057601A (en) 2000-09-25
AU721786C (en) 2001-08-02
TW552259B (en) 2003-09-11
CA2264207A1 (en) 1998-06-25
PE46999A1 (en) 1999-05-20
ID19142A (en) 1998-06-18
EP0951471A1 (en) 1999-10-27
HRP970693A2 (en) 1998-10-31
EP0951471B1 (en) 2004-03-17
DE69728165T2 (en) 2005-01-20
PT951471E (en) 2004-08-31
ES2216189T3 (en) 2004-10-16
NO992933L (en) 1999-06-16
NZ334702A (en) 2000-11-24
AU5899098A (en) 1998-07-15
JP2001506265A (en) 2001-05-15
AU721786B2 (en) 2000-07-13
US6281194B1 (en) 2001-08-28

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