MX9703208A - Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase. - Google Patents

Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase.

Info

Publication number
MX9703208A
MX9703208A MX9703208A MX9703208A MX9703208A MX 9703208 A MX9703208 A MX 9703208A MX 9703208 A MX9703208 A MX 9703208A MX 9703208 A MX9703208 A MX 9703208A MX 9703208 A MX9703208 A MX 9703208A
Authority
MX
Mexico
Prior art keywords
protein
farnesyl transferase
inhibitors
substituted tetra
pentapeptide inhibitors
Prior art date
Application number
MX9703208A
Other languages
Spanish (es)
Other versions
MXPA97003208A (en
Inventor
Gary Louis Bolton
Alfred Campsell
Richard Gowan
John Cooke Hodges
Donadl Hupe
Daniele M Leonard
Tomi Sawyer
Judith Sebolt Leopold
Francis John Tinney
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of MX9703208A publication Critical patent/MX9703208A/en
Publication of MXPA97003208A publication Critical patent/MXPA97003208A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Inhibitors of protein:farnesyl transferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
MXPA/A/1997/003208A 1994-12-09 1997-04-30 Tetra-y pentapeptidos substituidos deproteina inhibitors, farnesil transfer MXPA97003208A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35347394A 1994-12-09 1994-12-09
US353473 1994-12-09
PCT/US1995/014010 WO1996017861A1 (en) 1994-12-09 1995-10-27 Substituted tetra- and pentapeptide inhibitors of protein:farnesyl transferase

Publications (2)

Publication Number Publication Date
MX9703208A true MX9703208A (en) 1997-07-31
MXPA97003208A MXPA97003208A (en) 1997-12-01

Family

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Also Published As

Publication number Publication date
CA2204144A1 (en) 1996-06-13
AU3971295A (en) 1996-06-26
WO1996017861A1 (en) 1996-06-13
JPH10510261A (en) 1998-10-06

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