ATE250584T1 - Synthese von 5- oder 8-bromoisoquinolin derivaten - Google Patents
Synthese von 5- oder 8-bromoisoquinolin derivatenInfo
- Publication number
- ATE250584T1 ATE250584T1 AT99927733T AT99927733T ATE250584T1 AT E250584 T1 ATE250584 T1 AT E250584T1 AT 99927733 T AT99927733 T AT 99927733T AT 99927733 T AT99927733 T AT 99927733T AT E250584 T1 ATE250584 T1 AT E250584T1
- Authority
- AT
- Austria
- Prior art keywords
- bromoisoquinoline
- derivatives
- synthesis
- nitroisoquinoline
- bromo
- Prior art date
Links
- DPRIHFQFWWCIGY-UHFFFAOYSA-N 8-bromoisoquinoline Chemical class C1=NC=C2C(Br)=CC=CC2=C1 DPRIHFQFWWCIGY-UHFFFAOYSA-N 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- YWWZASFPWWPUBN-UHFFFAOYSA-N 1-bromoisoquinoline Chemical class C1=CC=C2C(Br)=NC=CC2=C1 YWWZASFPWWPUBN-UHFFFAOYSA-N 0.000 abstract 2
- CYJZJGYYTFQQBY-UHFFFAOYSA-N 5-bromoisoquinoline Chemical compound N1=CC=C2C(Br)=CC=CC2=C1 CYJZJGYYTFQQBY-UHFFFAOYSA-N 0.000 abstract 2
- ULGOLOXWHJEZNZ-UHFFFAOYSA-N 5-bromo-8-nitroisoquinoline Chemical class C1=NC=C2C([N+](=O)[O-])=CC=C(Br)C2=C1 ULGOLOXWHJEZNZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199800884 | 1998-06-22 | ||
| PCT/DK1999/000347 WO1999067218A2 (en) | 1998-06-22 | 1999-06-22 | Method of preparing 5- or 8-bromoisoquinoline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE250584T1 true ATE250584T1 (de) | 2003-10-15 |
Family
ID=8098619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99927733T ATE250584T1 (de) | 1998-06-22 | 1999-06-22 | Synthese von 5- oder 8-bromoisoquinolin derivaten |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6500954B1 (OSRAM) |
| EP (1) | EP1089976B1 (OSRAM) |
| JP (1) | JP2002518480A (OSRAM) |
| AT (1) | ATE250584T1 (OSRAM) |
| AU (1) | AU4498799A (OSRAM) |
| DE (1) | DE69911603T2 (OSRAM) |
| DK (1) | DK1089976T3 (OSRAM) |
| WO (1) | WO1999067218A2 (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040058950A1 (en) * | 2002-07-09 | 2004-03-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors |
| CA2492379A1 (en) * | 2002-07-17 | 2004-01-22 | Warner-Lambert Company Llc | Combination of an allosteric inhibitor of matrix metalloproteinase-13 with celecoxib or valdecoxib |
| US20040092522A1 (en) * | 2002-08-15 | 2004-05-13 | Field Mark John | Synergistic combinations |
| US7419981B2 (en) * | 2002-08-15 | 2008-09-02 | Pfizer Inc. | Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor |
| EP1651234B1 (en) * | 2003-07-25 | 2007-09-26 | F. Hoffmann-La Roche Ag | Combination of mglur2 antagonist and ache inhibitor for treatment of acute and/or chronic neurological disorders |
| CA2537402C (en) * | 2003-09-12 | 2009-05-05 | Pfizer Inc. | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| GB0322140D0 (en) * | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| DE102005061997A1 (de) * | 2005-12-23 | 2007-07-05 | Basf Ag | Naphthalintetracarbonsäurederivate und deren Verwendung |
| CN113264880B (zh) * | 2021-05-25 | 2022-08-30 | 湖北工业大学 | 一种4-卤代异喹啉化合物的制备方法 |
-
1999
- 1999-06-22 DE DE69911603T patent/DE69911603T2/de not_active Expired - Lifetime
- 1999-06-22 DK DK99927733T patent/DK1089976T3/da active
- 1999-06-22 EP EP99927733A patent/EP1089976B1/en not_active Expired - Lifetime
- 1999-06-22 WO PCT/DK1999/000347 patent/WO1999067218A2/en not_active Ceased
- 1999-06-22 AT AT99927733T patent/ATE250584T1/de not_active IP Right Cessation
- 1999-06-22 JP JP2000555872A patent/JP2002518480A/ja active Pending
- 1999-06-22 AU AU44987/99A patent/AU4498799A/en not_active Abandoned
-
2000
- 2000-10-10 US US09/685,025 patent/US6500954B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1089976A1 (en) | 2001-04-11 |
| DE69911603T2 (de) | 2004-07-29 |
| WO1999067218A3 (en) | 2000-03-16 |
| AU4498799A (en) | 2000-01-10 |
| EP1089976B1 (en) | 2003-09-24 |
| WO1999067218A2 (en) | 1999-12-29 |
| DE69911603D1 (de) | 2003-10-30 |
| DK1089976T3 (da) | 2004-01-19 |
| JP2002518480A (ja) | 2002-06-25 |
| US6500954B1 (en) | 2002-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1089976 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |