ATE235921T1 - Phosphonate- und nicht-phosphonate einheiten enthaltende polyamino-paramagnetische-chelate fuer anwendung in mri - Google Patents

Phosphonate- und nicht-phosphonate einheiten enthaltende polyamino-paramagnetische-chelate fuer anwendung in mri

Info

Publication number
ATE235921T1
ATE235921T1 AT94922745T AT94922745T ATE235921T1 AT E235921 T1 ATE235921 T1 AT E235921T1 AT 94922745 T AT94922745 T AT 94922745T AT 94922745 T AT94922745 T AT 94922745T AT E235921 T1 ATE235921 T1 AT E235921T1
Authority
AT
Austria
Prior art keywords
phosphonate
groups
mri
polyamino
units
Prior art date
Application number
AT94922745T
Other languages
English (en)
Inventor
Harry S Winchell
Joseph Y Klein
Rosa L Cyjon
Elliot D Simhon
Original Assignee
Chelator Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chelator Llc filed Critical Chelator Llc
Application granted granted Critical
Publication of ATE235921T1 publication Critical patent/ATE235921T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT94922745T 1993-08-13 1994-07-28 Phosphonate- und nicht-phosphonate einheiten enthaltende polyamino-paramagnetische-chelate fuer anwendung in mri ATE235921T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/106,764 US5409689A (en) 1993-08-13 1993-08-13 MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
PCT/US1994/008459 WO1995005118A1 (en) 1993-08-13 1994-07-28 Polyamino paramagnetic chelates which contain both phosphonate and non-phosphonate moieties for mri

Publications (1)

Publication Number Publication Date
ATE235921T1 true ATE235921T1 (de) 2003-04-15

Family

ID=22313124

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94922745T ATE235921T1 (de) 1993-08-13 1994-07-28 Phosphonate- und nicht-phosphonate einheiten enthaltende polyamino-paramagnetische-chelate fuer anwendung in mri

Country Status (7)

Country Link
US (1) US5409689A (de)
EP (1) EP0717639B1 (de)
JP (1) JP3007415B2 (de)
AT (1) ATE235921T1 (de)
AU (1) AU7374194A (de)
DE (1) DE69432418T2 (de)
WO (1) WO1995005118A1 (de)

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IT1297035B1 (it) 1997-12-30 1999-08-03 Bracco Spa Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6264966B1 (en) 2000-02-22 2001-07-24 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
EP1322653A2 (de) 2000-09-25 2003-07-02 The Procter & Gamble Company Metallkomplexe zur verwendung in medizinischen und therapeutischen anwendungen
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US6576760B2 (en) * 2001-01-11 2003-06-10 Chelator Llc Processes for synthesis of cyclic and linear polyamine chelators containing N-monosubstituted coordinating arms
US20050112066A1 (en) * 2003-11-26 2005-05-26 Concat Lp, A California Limited Partnership Complexes of cyclic polyaza chelators with cations of alkaline earth metals for enhanced biological activity
EP1778699A4 (de) * 2004-08-10 2009-02-25 Dow Global Technologies Inc Targeting von chelanten und chelaten
JP5345945B2 (ja) 2006-12-11 2013-11-20 ブラッコ・イメージング・ソシエタ・ペル・アチオニ フィブリン結合ペプチドおよびそのコンジュゲート
EP2476703A1 (de) 2011-01-14 2012-07-18 Bracco Imaging S.p.A Mit einem Bakterium kreuzreagierende menschliche Antikörper und ein Autoantigen aus atherosklerotischen Plaques
EP2147684A1 (de) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Selektiv gegen Metallproteasen wirkende Diagnosemittel
US8362281B2 (en) 2010-03-31 2013-01-29 General Electric Company Intermediates for hydroxylated contrast enhancement agents
US8722020B2 (en) 2010-03-31 2014-05-13 General Electric Company Hydroxylated contrast enhancement agents
US8765977B2 (en) 2010-03-31 2014-07-01 General Electric Company Hydroxylated contrast enhancement agents and imaging method
WO2012095516A1 (en) 2011-01-14 2012-07-19 Bracco Imaging Spa Human antibodies cross-reacting with a bacterial and a self antigen from atherosclerotic plaques
BR112018015143A2 (pt) 2016-02-09 2018-12-18 Bracco Suisse Sa proteína quimérica recombinante para direcionamento de selectinas
CN108779082B (zh) * 2016-04-13 2022-08-02 伯拉考成像股份公司 造影剂
JP2022507519A (ja) * 2018-11-16 2022-01-18 ザ リサーチ ファウンデイション フォー ザ ステイト ユニバーシティー オブ ニューヨーク アニオン性ペンダントおよび補助基を含む、鉄（ｉｉｉ）ｍｒｉ造影剤として使用するための化合物

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DE3237573A1 (de) * 1982-10-09 1984-04-12 Hoechst Ag, 6230 Frankfurt Technetium-99m-tri- und tetraphosphonate zur szintigraphischen dastellung res-haltiger organe und der lymphgefaesse und verfahren zu deren herstellung
SU1081169A1 (ru) * 1982-12-13 1984-03-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова @ , @ , @ -Трис(диоксифосфорилметил)-1,4,7-триазациклононан в качестве комплексона дл селективного св зывани катионов магни ,цинка,меди,никел
SU1098937A1 (ru) * 1983-03-25 1984-06-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова 1,4,7,10-Тетра/диоксифосфорилметил/-1,4,7,10-тетраазациклододекан в качестве комплексона дл св зывани катионов меди /п/,кобальта /п/,кадми /п/,свинца /п/ и лантана /ш/
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US5462725A (en) * 1993-05-06 1995-10-31 The Dow Chemical Company 2-pyridylmethylenepolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents

Also Published As

Publication number Publication date
US5409689A (en) 1995-04-25
JPH09501919A (ja) 1997-02-25
AU7374194A (en) 1995-03-14
EP0717639A4 (de) 1998-04-01
DE69432418T2 (de) 2003-10-30
EP0717639A1 (de) 1996-06-26
EP0717639B1 (de) 2003-04-02
WO1995005118A1 (en) 1995-02-23
DE69432418D1 (de) 2003-05-08
JP3007415B2 (ja) 2000-02-07

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