ATE232386T1 - Neue endiyn-chinonimine und verfahren zu deren herstellung und verwendung - Google Patents
Neue endiyn-chinonimine und verfahren zu deren herstellung und verwendungInfo
- Publication number
- ATE232386T1 ATE232386T1 AT95943647T AT95943647T ATE232386T1 AT E232386 T1 ATE232386 T1 AT E232386T1 AT 95943647 T AT95943647 T AT 95943647T AT 95943647 T AT95943647 T AT 95943647T AT E232386 T1 ATE232386 T1 AT E232386T1
- Authority
- AT
- Austria
- Prior art keywords
- linear
- branched
- branched alkyl
- co2h
- conjugates
- Prior art date
Links
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 150000004060 quinone imines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/347,952 US5622958A (en) | 1994-12-01 | 1994-12-01 | Enediyne quinone imines and methods of preparation and use thereof |
| PCT/US1995/015678 WO1996016655A1 (en) | 1994-12-01 | 1995-12-01 | Novel enediyne quinone imines and methods of preparation and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE232386T1 true ATE232386T1 (de) | 2003-02-15 |
Family
ID=23366001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95943647T ATE232386T1 (de) | 1994-12-01 | 1995-12-01 | Neue endiyn-chinonimine und verfahren zu deren herstellung und verwendung |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US5622958A (de) |
| EP (1) | EP0793497B1 (de) |
| AT (1) | ATE232386T1 (de) |
| AU (1) | AU715168B2 (de) |
| DE (1) | DE69529624D1 (de) |
| WO (1) | WO1996016655A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996003124A1 (en) * | 1994-07-27 | 1996-02-08 | California Institute Of Technology | Dynemicin analogs |
| US20030215421A1 (en) * | 1999-07-21 | 2003-11-20 | Mcdonald John R. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| US7157418B1 (en) | 1998-07-22 | 2007-01-02 | Osprey Pharmaceuticals, Ltd. | Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders |
| US6787150B2 (en) * | 2002-07-22 | 2004-09-07 | Kes Associates | Seed coating for bypassing the ruminant digestive tract |
| EP2476441A1 (de) | 2011-01-13 | 2012-07-18 | Universitat Autònoma De Barcelona | Verfahren und Reagenzien zur effizienten und gezielten Abgabe von therapeutischen Molekülen an CXCR4-Zellen |
| EP3296320A1 (de) | 2012-03-08 | 2018-03-21 | Halozyme, Inc. | Bedingt aktive antikörper gegen den epidermalen wachstumsfaktorrezeptor und verfahren zur verwendung davon |
| MX2016003256A (es) | 2013-09-12 | 2016-06-07 | Halozyme Inc | Anticuerpos modificados del receptor de factor de crecimiento anti-epidermico y metodos de uso de los mismos. |
| EP2930238A1 (de) | 2014-04-09 | 2015-10-14 | Fundacio Centre de Regulacio Genomica | Zusammensetzungen zur Behandlung von Krebs |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| EP3427756A1 (de) | 2017-07-14 | 2019-01-16 | Universidad Autónoma De Barcelona (UAB) | Therapeutische nanokonjugate und verwendungen davon |
| EP3724225A1 (de) | 2017-12-15 | 2020-10-21 | Juno Therapeutics, Inc. | Anti-cct5-bindende moleküle und verfahren zur verwendung davon |
| EP3842452A1 (de) | 2019-12-26 | 2021-06-30 | Universitat Autònoma de Barcelona | Gerüstproteine und therapeutische nanokonjugate auf nidogenbasis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5281710A (en) * | 1990-08-01 | 1994-01-25 | The Scripps Research Institute | Dynemicin analogs: synthesis, methods of preparation and use |
| US5276159A (en) * | 1990-08-01 | 1994-01-04 | The Scripps Research Institute | Dynemicin analogs: syntheses, methods of preparation and use |
| WO1996003124A1 (en) * | 1994-07-27 | 1996-02-08 | California Institute Of Technology | Dynemicin analogs |
-
1994
- 1994-12-01 US US08/347,952 patent/US5622958A/en not_active Expired - Fee Related
-
1995
- 1995-12-01 AT AT95943647T patent/ATE232386T1/de not_active IP Right Cessation
- 1995-12-01 AU AU45068/96A patent/AU715168B2/en not_active Ceased
- 1995-12-01 DE DE69529624T patent/DE69529624D1/de not_active Expired - Lifetime
- 1995-12-01 WO PCT/US1995/015678 patent/WO1996016655A1/en active IP Right Grant
- 1995-12-01 EP EP95943647A patent/EP0793497B1/de not_active Expired - Lifetime
- 1995-12-01 US US08/849,658 patent/US6020341A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0793497B1 (de) | 2003-02-12 |
| AU715168B2 (en) | 2000-01-20 |
| US6020341A (en) | 2000-02-01 |
| EP0793497A1 (de) | 1997-09-10 |
| US5622958A (en) | 1997-04-22 |
| AU4506896A (en) | 1996-06-19 |
| EP0793497A4 (de) | 1998-01-28 |
| WO1996016655A1 (en) | 1996-06-06 |
| DE69529624D1 (de) | 2003-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |