ATE230979T1 - METHOD FOR PRODUCING NEW MEDICINAL FORMULATIONS CONTAINING FENOFIBRATE, MEDICINAL FORMULATIONS PRODUCED THEREFROM AND USE THEREOF - Google Patents

METHOD FOR PRODUCING NEW MEDICINAL FORMULATIONS CONTAINING FENOFIBRATE, MEDICINAL FORMULATIONS PRODUCED THEREFROM AND USE THEREOF

Info

Publication number
ATE230979T1
ATE230979T1 AT99941732T AT99941732T ATE230979T1 AT E230979 T1 ATE230979 T1 AT E230979T1 AT 99941732 T AT99941732 T AT 99941732T AT 99941732 T AT99941732 T AT 99941732T AT E230979 T1 ATE230979 T1 AT E230979T1
Authority
AT
Austria
Prior art keywords
medicinal formulations
fenofibrate
produced therefrom
producing new
containing fenofibrate
Prior art date
Application number
AT99941732T
Other languages
German (de)
Inventor
Claude Laruelle
Rene Gimet
Dominique Toselli
Original Assignee
Cll Pharma Arenas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Cll Pharma Arenas filed Critical Cll Pharma Arenas
Application granted granted Critical
Publication of ATE230979T1 publication Critical patent/ATE230979T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention concerns a method for preparing novel galenic formulations for providing fenofibrate with enhanced bioavailability when it is orally absorbed, and consisting in: (a) micronizing fenofibrate; (b) granulating the fenofibrate in the presence of a liquid medium comprising a surfactant, water and water-miscible alcohol; and (c) drying the resulting granular material. The invention also concerns the galenic formulations obtained by said method. Said formulations are used for preparing a medicine for oral administration and comprising fenofibrate as active principle, in particular for treating hypercholesterolemia and hypertriglyceridemia.
AT99941732T 1998-09-17 1999-09-10 METHOD FOR PRODUCING NEW MEDICINAL FORMULATIONS CONTAINING FENOFIBRATE, MEDICINAL FORMULATIONS PRODUCED THEREFROM AND USE THEREOF ATE230979T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9811611A FR2783421B1 (en) 1998-09-17 1998-09-17 PROCESS FOR THE PREPARATION OF NOVEL GALENIC FORMULATIONS OF FENOFIBRATE, GALENIC FORMULATIONS OBTAINED BY SAID PROCESS AND THEIR APPLICATIONS
PCT/FR1999/002155 WO2000016749A1 (en) 1998-09-17 1999-09-10 Method for preparing novel fenofibrate galenic formulations, galenic formulations obtained and applications

Publications (1)

Publication Number Publication Date
ATE230979T1 true ATE230979T1 (en) 2003-02-15

Family

ID=9530543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99941732T ATE230979T1 (en) 1998-09-17 1999-09-10 METHOD FOR PRODUCING NEW MEDICINAL FORMULATIONS CONTAINING FENOFIBRATE, MEDICINAL FORMULATIONS PRODUCED THEREFROM AND USE THEREOF

Country Status (16)

Country Link
EP (1) EP1112064B1 (en)
JP (1) JP2002526438A (en)
KR (1) KR100712032B1 (en)
AT (1) ATE230979T1 (en)
AU (1) AU5523599A (en)
BR (1) BR9913782A (en)
CA (1) CA2342742A1 (en)
CZ (1) CZ298634B6 (en)
DE (1) DE69904954D1 (en)
ES (1) ES2190819T3 (en)
FR (1) FR2783421B1 (en)
MX (1) MXPA01002801A (en)
PL (1) PL194847B1 (en)
SK (1) SK284950B6 (en)
WO (1) WO2000016749A1 (en)
ZA (1) ZA200101894B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982281B1 (en) 2000-11-17 2006-01-03 Lipocine Inc Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
FR2795961B1 (en) * 1999-07-09 2004-05-28 Ethypharm Lab Prod Ethiques PHARMACEUTICAL COMPOSITION CONTAINING MICRONIZED FENOFIBRATE, A SURFACTANT AND A BINDING CELLULOSIC DERIVATIVE AND PREPARATION METHOD
US7276249B2 (en) 2002-05-24 2007-10-02 Elan Pharma International, Ltd. Nanoparticulate fibrate formulations
FR2819720B1 (en) 2001-01-22 2004-03-12 Fournier Lab Sa NEW FENOFIBRATE TABLETS
GB0119480D0 (en) 2001-08-09 2001-10-03 Jagotec Ag Novel compositions
AU2003263480A1 (en) * 2002-09-24 2004-04-19 Ranbaxy Laboratories Limited Oral pharmaceutical compositions of fenofibrate having high bioavailability
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
US11304960B2 (en) 2009-01-08 2022-04-19 Chandrashekar Giliyar Steroidal compositions
US9034858B2 (en) 2010-11-30 2015-05-19 Lipocine Inc. High-strength testosterone undecanoate compositions
US9358241B2 (en) 2010-11-30 2016-06-07 Lipocine Inc. High-strength testosterone undecanoate compositions
US20120148675A1 (en) 2010-12-10 2012-06-14 Basawaraj Chickmath Testosterone undecanoate compositions
EP2842547A1 (en) 2013-08-27 2015-03-04 Freund Pharmatec Ltd. Improved fenofibrate compositions
EP2878311A1 (en) 2013-11-27 2015-06-03 Freund Pharmatec Ltd. Solubility Enhancement for Hydrophobic Drugs
WO2016033549A2 (en) 2014-08-28 2016-03-03 Lipocine Inc. (17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
US9498485B2 (en) 2014-08-28 2016-11-22 Lipocine Inc. Bioavailable solid state (17-β)-hydroxy-4-androsten-3-one esters
CN104352466A (en) * 2014-11-17 2015-02-18 辰欣药业股份有限公司 Fenofibrate composition and preparation thereof
EP3544614A4 (en) 2016-11-28 2020-08-05 Lipocine Inc. Oral testosterone undecanoate therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2627696B1 (en) * 1988-02-26 1991-09-13 Fournier Innovation Synergie NEW GALENIC FORM OF FENOFIBRATE
FR2722984B1 (en) * 1994-07-26 1996-10-18 Effik Lab PROCESS FOR THE PREPARATION OF DRY PHARMACEUTICAL FORMS AND THE PHARMACEUTICAL COMPOSITIONS THUS PRODUCED
SI9500173B (en) * 1995-05-19 2002-02-28 Lek, Three-phase pharmaceutical form with constant and controlled release of amorphous active ingredient for single daily application
DE19608750A1 (en) * 1996-03-06 1997-09-11 Durachemie Gmbh & Co Kg Process for the production of fenofibrate preparations
FR2758459B1 (en) * 1997-01-17 1999-05-07 Pharma Pass FENOFIBRATE PHARMACEUTICAL COMPOSITION HAVING HIGH BIODAVAILABILITY AND PROCESS FOR PREPARING THE SAME

Also Published As

Publication number Publication date
ZA200101894B (en) 2003-01-07
KR20010075182A (en) 2001-08-09
MXPA01002801A (en) 2002-04-08
FR2783421B1 (en) 2000-11-24
KR100712032B1 (en) 2007-04-27
EP1112064A1 (en) 2001-07-04
SK284950B6 (en) 2006-03-02
PL346714A1 (en) 2002-02-25
ES2190819T3 (en) 2003-08-16
CZ2001979A3 (en) 2001-08-15
PL194847B1 (en) 2007-07-31
AU5523599A (en) 2000-04-10
SK3552001A3 (en) 2001-09-11
WO2000016749A1 (en) 2000-03-30
CA2342742A1 (en) 2000-03-30
BR9913782A (en) 2001-06-05
CZ298634B6 (en) 2007-11-28
DE69904954D1 (en) 2003-02-20
FR2783421A1 (en) 2000-03-24
JP2002526438A (en) 2002-08-20
EP1112064B1 (en) 2003-01-15

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties