ATE209255T1 - METHOD FOR PRODUCING 7-ADCA BY REACTION OF PENICILLINS G USING EXPANDASE - Google Patents

METHOD FOR PRODUCING 7-ADCA BY REACTION OF PENICILLINS G USING EXPANDASE

Info

Publication number
ATE209255T1
ATE209255T1 AT96917498T AT96917498T ATE209255T1 AT E209255 T1 ATE209255 T1 AT E209255T1 AT 96917498 T AT96917498 T AT 96917498T AT 96917498 T AT96917498 T AT 96917498T AT E209255 T1 ATE209255 T1 AT E209255T1
Authority
AT
Austria
Prior art keywords
pct
adca
expandase
penicillins
reaction
Prior art date
Application number
AT96917498T
Other languages
German (de)
Inventor
Roelof Ary Lans Bovenberg
Bertus Pieter Koekman
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Priority claimed from PCT/EP1996/002434 external-priority patent/WO1996038580A1/en
Application granted granted Critical
Publication of ATE209255T1 publication Critical patent/ATE209255T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

PCT No. PCT/EP96/02434 Sec. 371 Date Feb. 18, 1998 Sec. 102(e) Date Feb. 18, 1998 PCT Filed Jun. 3, 1996 PCT Pub. No. WO96/38580 PCT Pub. Date Dec. 5, 1996A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase.
AT96917498T 1995-06-02 1996-06-03 METHOD FOR PRODUCING 7-ADCA BY REACTION OF PENICILLINS G USING EXPANDASE ATE209255T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP95201455 1995-06-02
PCT/EP1996/002434 WO1996038580A1 (en) 1995-06-02 1996-06-03 Process for the production of 7-adca via expandase activity on penicillin g

Publications (1)

Publication Number Publication Date
ATE209255T1 true ATE209255T1 (en) 2001-12-15

Family

ID=8220352

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96917498T ATE209255T1 (en) 1995-06-02 1996-06-03 METHOD FOR PRODUCING 7-ADCA BY REACTION OF PENICILLINS G USING EXPANDASE

Country Status (14)

Country Link
US (1) US6020151A (en)
JP (1) JPH11505726A (en)
KR (1) KR100421225B1 (en)
CN (1) CN1084791C (en)
AT (1) ATE209255T1 (en)
BR (1) BR9608954A (en)
CA (1) CA2223105A1 (en)
DE (1) DE69617228T2 (en)
DK (1) DK0828850T3 (en)
ES (1) ES2167568T3 (en)
HU (1) HUP9801906A3 (en)
PL (1) PL182509B1 (en)
RU (1) RU2192471C2 (en)
SK (1) SK280539B6 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6383773B2 (en) * 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
MD4030C2 (en) * 2009-12-12 2010-11-30 Тимофей ПОПЕСКУ Base for the preparation of nutrient media for cultivation of microorganisms of Mycobacterium genus and process for the obtaining thereof
CN101880302B (en) * 2010-06-11 2012-10-24 中国科学院海洋研究所 Polyhydroxylated sterol derivative as well as preparation and application thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT43644A (en) * 1986-11-17 1987-11-30 Univ Oxford Process for producing 3-substituted-cephalosporines
US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
CZ288721B6 (en) * 1991-10-15 2001-08-15 Dsm Gist B. V. Novel bioprocess for preparing 7-aminodeacetylcephalosporanic acid
WO1995004149A1 (en) * 1993-07-30 1995-02-09 Gist-Brocades B.V. Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca
BR9407108A (en) * 1993-07-30 1996-08-27 Gist Brocades Nv Process for the preparation and recovery of cephalosporanic 7-amino deacetoxy acid (7-adca) recombinant DNA vector and host cell transformed with a defined vector
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G

Also Published As

Publication number Publication date
CA2223105A1 (en) 1996-12-05
HUP9801906A2 (en) 1998-11-30
CN1084791C (en) 2002-05-15
RU2192471C2 (en) 2002-11-10
DE69617228T2 (en) 2002-06-27
KR100421225B1 (en) 2004-06-18
HUP9801906A3 (en) 2001-01-29
ES2167568T3 (en) 2002-05-16
DK0828850T3 (en) 2002-05-21
JPH11505726A (en) 1999-05-25
DE69617228D1 (en) 2002-01-03
CN1190440A (en) 1998-08-12
SK163097A3 (en) 1998-05-06
US6020151A (en) 2000-02-01
SK280539B6 (en) 2000-03-13
PL323639A1 (en) 1998-04-14
PL182509B1 (en) 2002-01-31
BR9608954A (en) 1999-03-02
KR19990022230A (en) 1999-03-25

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee