ATE205084T1 - 2,4-diaryl-1,3-dithiolane als platelet activating faktor rezeptorblocker und 5-lipoxygenasehemmer - Google Patents
2,4-diaryl-1,3-dithiolane als platelet activating faktor rezeptorblocker und 5-lipoxygenasehemmerInfo
- Publication number
- ATE205084T1 ATE205084T1 AT92907890T AT92907890T ATE205084T1 AT E205084 T1 ATE205084 T1 AT E205084T1 AT 92907890 T AT92907890 T AT 92907890T AT 92907890 T AT92907890 T AT 92907890T AT E205084 T1 ATE205084 T1 AT E205084T1
- Authority
- AT
- Austria
- Prior art keywords
- diaryl
- dithiolanes
- factor receptor
- activating factor
- receptor blocker
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66455391A | 1991-03-04 | 1991-03-04 | |
| PCT/US1992/001830 WO1992015294A1 (en) | 1991-03-04 | 1992-03-04 | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE205084T1 true ATE205084T1 (de) | 2001-09-15 |
Family
ID=24666446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92907890T ATE205084T1 (de) | 1991-03-04 | 1992-03-04 | 2,4-diaryl-1,3-dithiolane als platelet activating faktor rezeptorblocker und 5-lipoxygenasehemmer |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0574510B1 (de) |
| JP (1) | JP3216647B2 (de) |
| AT (1) | ATE205084T1 (de) |
| AU (1) | AU666844B2 (de) |
| CA (1) | CA2104951A1 (de) |
| DE (1) | DE69232046T2 (de) |
| DK (1) | DK0574510T3 (de) |
| ES (1) | ES2163399T3 (de) |
| HU (1) | HUT65173A (de) |
| WO (1) | WO1992015294A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530141A (en) * | 1992-03-04 | 1996-06-25 | Center For Innovative Technology | 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
| US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5358938A (en) * | 1992-07-13 | 1994-10-25 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
| CA2140034A1 (en) | 1992-07-13 | 1994-01-20 | Xiong Cai | 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders |
| US5648486A (en) * | 1992-07-13 | 1997-07-15 | Cytomed, Inc. | Compounds and methods for the treatment of inflammatory and immune disorders |
| ES2062943B1 (es) * | 1993-03-23 | 1995-11-16 | Uriach & Cia Sa J | Nuevos derivados de la (2-metil-3-piridil) cianometilpiperazinas. |
| US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
| EP1094805A4 (de) | 1998-07-03 | 2002-08-28 | Millennium Pharm Inc | Alicyclische verbindungen mit substituiertem sauerstoffatom, sowie deren bereitungsverfahren |
| CA2342156A1 (en) | 1998-07-03 | 2000-01-13 | Andappan Murugaiah Subbaiah Murugaiah | Methods for synthesis of substituted tetrahydrofuran compound |
| US6255498B1 (en) | 1998-10-16 | 2001-07-03 | Millennium Pharmaceuticals, Inc. | Method for synthesizing diaryl-substituted heterocyclic compounds, including tetrahydrofurans |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539332A (en) * | 1983-11-14 | 1985-09-03 | Merck & Co., Inc. | 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists |
| CN1030415A (zh) * | 1987-02-20 | 1989-01-18 | 山之内制药株式会社 | 饱和的杂环碳酰胺衍生物和它的制备方法 |
| EP0365089A3 (de) * | 1988-10-18 | 1991-06-05 | Merck & Co. Inc. | 2-Aryl-5(3-methoxy-5-(hydroxypropylsulfonyl)-4-propoxyphenyl)tetrahydrothiophen und Analoge |
-
1992
- 1992-03-04 AU AU15333/92A patent/AU666844B2/en not_active Ceased
- 1992-03-04 JP JP50744392A patent/JP3216647B2/ja not_active Expired - Fee Related
- 1992-03-04 AT AT92907890T patent/ATE205084T1/de not_active IP Right Cessation
- 1992-03-04 DK DK92907890T patent/DK0574510T3/da active
- 1992-03-04 HU HU9302491A patent/HUT65173A/hu unknown
- 1992-03-04 CA CA002104951A patent/CA2104951A1/en not_active Abandoned
- 1992-03-04 ES ES92907890T patent/ES2163399T3/es not_active Expired - Lifetime
- 1992-03-04 WO PCT/US1992/001830 patent/WO1992015294A1/en active IP Right Grant
- 1992-03-04 DE DE69232046T patent/DE69232046T2/de not_active Expired - Fee Related
- 1992-03-04 EP EP92907890A patent/EP0574510B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06507885A (ja) | 1994-09-08 |
| EP0574510A1 (de) | 1993-12-22 |
| DK0574510T3 (da) | 2001-12-03 |
| HUT65173A (en) | 1994-05-02 |
| HU9302491D0 (en) | 1993-12-28 |
| AU666844B2 (en) | 1996-02-29 |
| JP3216647B2 (ja) | 2001-10-09 |
| ES2163399T3 (es) | 2002-02-01 |
| EP0574510A4 (en) | 1994-07-06 |
| AU1533392A (en) | 1992-10-06 |
| EP0574510B1 (de) | 2001-09-05 |
| DE69232046D1 (en) | 2001-10-11 |
| WO1992015294A1 (en) | 1992-09-17 |
| DE69232046T2 (de) | 2002-05-02 |
| CA2104951A1 (en) | 1992-09-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| REN | Ceased due to non-payment of the annual fee |