ATE191911T1 - NEW QUINOLOONECARBONIC ACID DERIVATIVES - Google Patents

NEW QUINOLOONECARBONIC ACID DERIVATIVES

Info

Publication number
ATE191911T1
ATE191911T1 AT94904772T AT94904772T ATE191911T1 AT E191911 T1 ATE191911 T1 AT E191911T1 AT 94904772 T AT94904772 T AT 94904772T AT 94904772 T AT94904772 T AT 94904772T AT E191911 T1 ATE191911 T1 AT E191911T1
Authority
AT
Austria
Prior art keywords
formula
group
compound
hydrogen atom
mean
Prior art date
Application number
AT94904772T
Other languages
German (de)
Inventor
Sung June Yoon
Yong Ho Chung
Chi Woo Lee
Yoon Seok Oh
Dong Rack Choi
Nam Doo Kim
Original Assignee
Dong Wha Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dong Wha Pharm Ind Co Ltd filed Critical Dong Wha Pharm Ind Co Ltd
Priority claimed from PCT/KR1994/000006 external-priority patent/WO1995005373A1/en
Application granted granted Critical
Publication of ATE191911T1 publication Critical patent/ATE191911T1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to new derivatives of quinolone carboxylic acid of the formula (I) $$$, their pharmaceutically acceptable salts and hydrates where X means hydrocarbon group, fluorocarbon group or nitrogen atom; Y means hydrogen atom or methyl group; $$$ means hydrogen atom or $$$-alkyl group; $$$ means a group of the formula (a) $$$ where A and B mean fluorocarbon group or nitrogen atom at condition that when A is CF then B is N and when A is N then B is CF; $$$ means a group of the formula (b) $$$ where substitute $$$ means amino-group with racemate or (S)-enantiomer formation, or a group of the formula (c) $$$ where substituents $$$ and $$$ mean hydrogen atom or $$$-alkyl group. Derivative of quinolone carboxylic acid of the formula (I) is synthesized by condensation of compound of the formula (II) $$$ and compound of the formula $$$ in solvent in the presence of acid acceptor and excess of compound of the formula $$$ that is one of reagents. Solvent is taken from a group involving pyridine, acetonitrile, N,N-dimethylformamide. In compound of the formula (II) and compound of the formula $$$ substituents X, Y, Z, $$$ and $$$ mean values indicated above. EFFECT: improved method of synthesis. 11 cl, 6 tbl, 29 ex
AT94904772T 1993-08-13 1994-01-21 NEW QUINOLOONECARBONIC ACID DERIVATIVES ATE191911T1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019930015724A KR0169500B1 (en) 1993-08-13 1993-08-13 Novel quinolone carboxylic acid derivatives and their preparation method
PCT/KR1994/000006 WO1995005373A1 (en) 1993-08-13 1994-01-21 Novel quinolone carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
ATE191911T1 true ATE191911T1 (en) 2000-05-15

Family

ID=19361236

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94904772T ATE191911T1 (en) 1993-08-13 1994-01-21 NEW QUINOLOONECARBONIC ACID DERIVATIVES

Country Status (4)

Country Link
KR (1) KR0169500B1 (en)
AT (1) ATE191911T1 (en)
DE (1) DE69424052T2 (en)
RU (1) RU2120941C1 (en)

Also Published As

Publication number Publication date
KR0169500B1 (en) 1999-01-15
DE69424052T2 (en) 2001-01-11
KR950005824A (en) 1995-03-20
RU2120941C1 (en) 1998-10-27
DE69424052D1 (en) 2000-05-25

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Legal Events

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