ATE185348T1 - Glykosidierungsverfahren - Google Patents
GlykosidierungsverfahrenInfo
- Publication number
- ATE185348T1 ATE185348T1 AT92917211T AT92917211T ATE185348T1 AT E185348 T1 ATE185348 T1 AT E185348T1 AT 92917211 T AT92917211 T AT 92917211T AT 92917211 T AT92917211 T AT 92917211T AT E185348 T1 ATE185348 T1 AT E185348T1
- Authority
- AT
- Austria
- Prior art keywords
- steroidal
- activity
- pyranoside
- glycosylated
- steroid
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000005858 glycosidation reaction Methods 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000000144 pharmacologic effect Effects 0.000 abstract 2
- 229930002534 steroid glycoside Natural products 0.000 abstract 2
- 150000008143 steroidal glycosides Chemical class 0.000 abstract 2
- 230000003637 steroidlike Effects 0.000 abstract 2
- 150000003431 steroids Chemical class 0.000 abstract 2
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical class N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000007809 chemical reaction catalyst Substances 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- FSMCJUNYLQOAIM-UQBZCTSOSA-N cholesteryl beta-D-glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O FSMCJUNYLQOAIM-UQBZCTSOSA-N 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 229930182470 glycoside Natural products 0.000 abstract 1
- 150000002338 glycosides Chemical class 0.000 abstract 1
- 230000013595 glycosylation Effects 0.000 abstract 1
- 238000006206 glycosylation reaction Methods 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000004957 immunoregulator effect Effects 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- RYVMUASDIZQXAA-UHFFFAOYSA-N pyranoside Natural products O1C2(OCC(C)C(OC3C(C(O)C(O)C(CO)O3)O)C2)C(C)C(C2(CCC3C4(C)CC5O)C)C1CC2C3CC=C4CC5OC(C(C1O)O)OC(CO)C1OC(C1OC2C(C(OC3C(C(O)C(O)C(CO)O3)O)C(O)C(CO)O2)O)OC(CO)C(O)C1OC1OCC(O)C(O)C1O RYVMUASDIZQXAA-UHFFFAOYSA-N 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73391591A | 1991-07-22 | 1991-07-22 | |
| US81569192A | 1992-01-24 | 1992-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE185348T1 true ATE185348T1 (de) | 1999-10-15 |
Family
ID=27112641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92917211T ATE185348T1 (de) | 1991-07-22 | 1992-07-21 | Glykosidierungsverfahren |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0597018B1 (de) |
| JP (1) | JPH06501499A (de) |
| CN (1) | CN1031643C (de) |
| AT (1) | ATE185348T1 (de) |
| AU (1) | AU2401192A (de) |
| CA (1) | CA2113819C (de) |
| DE (1) | DE69230104T2 (de) |
| IL (1) | IL102566A0 (de) |
| TW (1) | TW202455B (de) |
| WO (1) | WO1993001821A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107056878B (zh) * | 2017-03-24 | 2019-07-05 | 昆明理工大学 | 一个d-吡喃环孕甾烷糖苷化合物及其应用 |
| KR102124470B1 (ko) * | 2019-12-13 | 2020-06-18 | 주식회사 큐라클 | 신규 혈관누출 차단제의 고수율 제조방법 |
| CN116217642A (zh) * | 2023-03-09 | 2023-06-06 | 西北大学 | 木樨榄苷类化合物及其在制备抗肿瘤药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI46067C (fi) * | 1968-04-06 | 1972-12-11 | Hoechst Ag | Menetelmä digitoksigeniiniglykosidien valmistamiseksi. |
| US4415731A (en) * | 1981-03-30 | 1983-11-15 | Merck & Co., Inc. | Process for the preparation of methyl 2,6-dideoxy-α-D-arabino-hexopyranoside |
| DE4001895A1 (de) * | 1990-01-23 | 1991-07-25 | Harrier Gmbh | Herstellung von insbesondere steroidglykosiden |
-
1992
- 1992-07-20 IL IL102566A patent/IL102566A0/xx unknown
- 1992-07-21 EP EP92917211A patent/EP0597018B1/de not_active Expired - Lifetime
- 1992-07-21 CN CN92109745A patent/CN1031643C/zh not_active Expired - Fee Related
- 1992-07-21 JP JP5503027A patent/JPH06501499A/ja active Pending
- 1992-07-21 CA CA002113819A patent/CA2113819C/en not_active Expired - Fee Related
- 1992-07-21 AU AU24011/92A patent/AU2401192A/en not_active Abandoned
- 1992-07-21 WO PCT/US1992/006063 patent/WO1993001821A1/en not_active Ceased
- 1992-07-21 DE DE69230104T patent/DE69230104T2/de not_active Expired - Fee Related
- 1992-07-21 AT AT92917211T patent/ATE185348T1/de not_active IP Right Cessation
- 1992-08-14 TW TW081106445A patent/TW202455B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0597018A4 (de) | 1996-02-07 |
| IL102566A0 (en) | 1993-01-14 |
| DE69230104T2 (de) | 2000-08-24 |
| CA2113819A1 (en) | 1993-02-04 |
| EP0597018B1 (de) | 1999-10-06 |
| AU2401192A (en) | 1993-02-23 |
| EP0597018A1 (de) | 1994-05-18 |
| JPH06501499A (ja) | 1994-02-17 |
| CN1073179A (zh) | 1993-06-16 |
| CA2113819C (en) | 2009-01-06 |
| WO1993001821A1 (en) | 1993-02-04 |
| CN1031643C (zh) | 1996-04-24 |
| TW202455B (de) | 1993-03-21 |
| DE69230104D1 (de) | 1999-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |