US5652105A
(en)
*
|
1995-07-28 |
1997-07-29 |
Health Research, Inc. |
Substrate for detection of mammalian 5-C-DNA methyltransferase
|
WO1997044346A2
(en)
*
|
1996-05-22 |
1997-11-27 |
Mcgill University |
Specific inhibitors of dna methyltransferase enzyme
|
US6268137B1
(en)
|
1996-05-22 |
2001-07-31 |
Methylgene, Inc. |
Specific inhibitors of DNA methyl transferase
|
US7138384B1
(en)
|
1997-08-29 |
2006-11-21 |
The Regents Of The University Of California |
Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
|
AU1138699A
(en)
*
|
1997-11-12 |
1999-05-31 |
Mcgill University |
Dna demethylase, therapeutic and diagnostic uses thereof
|
DE19754482A1
(en)
*
|
1997-11-27 |
1999-07-01 |
Epigenomics Gmbh |
Process for making complex DNA methylation fingerprints
|
US7026155B2
(en)
*
|
1999-02-02 |
2006-04-11 |
Regents Of The University Of California |
Method of reducing bacterial proliferation
|
CA2291367A1
(en)
*
|
1999-12-06 |
2001-06-06 |
Isabelle Henry |
Genetic constructions having a reduced or an increased number of epigenetic control regions and methods of use thereof
|
DE10010282B4
(en)
|
2000-02-25 |
2006-11-16 |
Epigenomics Ag |
Method for the detection of cytosine methylation in DNA samples
|
EP1370685A2
(en)
|
2000-04-06 |
2003-12-17 |
Epigenomics AG |
Diagnosis of diseases associated with dna repair
|
WO2003006987A1
(en)
*
|
2000-12-11 |
2003-01-23 |
The Salk Institute For Biological Studies |
Methods and compositions for determining enzymatic activity and specificity of methyltransferases
|
WO2002101353A2
(en)
*
|
2001-06-08 |
2002-12-19 |
U.S. Genomics, Inc. |
Methods and products for analyzing nucleic acids based on methylation status
|
AU2002322805B2
(en)
*
|
2001-07-31 |
2007-11-08 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Inhibitor of DNA methylation
|
DE10154317B4
(en)
|
2001-10-26 |
2005-06-09 |
Epigenomics Ag |
Method for the detection of cytosine methylations in immobilized DNA samples
|
EP1340818A1
(en)
|
2002-02-27 |
2003-09-03 |
Epigenomics AG |
Method and nucleic acids for the analysis of a colon cell proliferative disorder
|
US6890736B1
(en)
|
2002-09-20 |
2005-05-10 |
Immunex Corporation |
Methods for producing proteins in cultured cells
|
WO2005059172A2
(en)
|
2003-12-11 |
2005-06-30 |
Epigenomics Ag |
Method and nucleic acids for the improved treatment of breast cell proliferative disorders
|
CA2500255A1
(en)
|
2002-10-01 |
2004-04-29 |
Epigenomics Ag |
Method and nucleic acids for the treatment of breast cell proliferative disorders
|
AU2003295444A1
(en)
*
|
2002-11-15 |
2004-06-15 |
The Board Of Trustees Of The University Of Illinois |
Methods for in vitro expansion of hematopoietic stem cells
|
AU2003902704A0
(en)
*
|
2003-05-29 |
2003-06-19 |
Crc For Waste Management And Pollution Control Limited Of Unsw |
Process for producing a nanoscale zero-valent metal
|
EP1636386B1
(en)
|
2003-06-23 |
2015-08-05 |
Epigenomics AG |
Methods and nucleic acids for analyses of colorectal cell proliferative disorders
|
EP2354249A1
(en)
|
2003-06-23 |
2011-08-10 |
Epigenomics AG |
Methods and nucleic acids for analyses of colorectal cell proliferative disorders
|
ATE494390T1
(en)
|
2003-06-23 |
2011-01-15 |
Epigenomics Ag |
METHOD AND NUCLEIC ACIDS FOR ANALYZING DISORDERS IN COLON CELL PROLIFERATION
|
WO2005012575A1
(en)
*
|
2003-08-01 |
2005-02-10 |
U.S. Genomics, Inc. |
Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions
|
AU2004295712B2
(en)
|
2003-12-01 |
2011-05-19 |
Epigenomics Ag |
Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
|
US8415315B2
(en)
|
2004-05-06 |
2013-04-09 |
University Of Central Florida Research Foundation, Inc. |
Methods and compositions for inhibiting the proliferation of cancer cells
|
EP1778865A1
(en)
|
2004-06-23 |
2007-05-02 |
Epigenomics AG |
Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
|
US20090298054A1
(en)
|
2004-07-18 |
2009-12-03 |
Epigenomics Ag |
Epigenetic methods and nucleic acids for the detection of breast cell proliferative disorders
|
EP2311984A1
(en)
|
2004-12-02 |
2011-04-20 |
Epigenomics AG |
Methods and nucleic acids for the analysis of gene expression associated with the prognosis of prostate cell proliferative disorders
|
US7250416B2
(en)
|
2005-03-11 |
2007-07-31 |
Supergen, Inc. |
Azacytosine analogs and derivatives
|
WO2006107751A2
(en)
*
|
2005-04-01 |
2006-10-12 |
Methylgene, Inc. |
Combined therapy utilizing reduction of dna methyltansferase expression and/or activity and interferon
|
SG183708A1
(en)
|
2005-04-15 |
2012-09-27 |
Epigenomics Ag |
Methods and nucleic acids for analyses of cellular proliferative disorders
|
EP1885884A2
(en)
|
2005-05-02 |
2008-02-13 |
University Of Southern California |
DNA METHYLATION MARKERS ASSOCIATED WITH THE CpG ISLAND METHYLATOR PHENOTYPE (CIMP) IN HUMAN COLORECTAL CANCER
|
ES2623221T3
(en)
*
|
2005-05-20 |
2017-07-10 |
Methylgene Inc |
VEGF receptor and HGF receptor signaling inhibitors
|
US20090191548A1
(en)
|
2005-09-29 |
2009-07-30 |
Epigenomics Ag |
Methods and nucleic acids for the analysis of gene expression associated with tissue classification
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
CN101437933B
(en)
|
2005-12-28 |
2013-11-06 |
斯克里普斯研究所 |
Natural antisense and non-coding RNA transcripts as drug targets
|
AR060061A1
(en)
*
|
2006-03-22 |
2008-05-21 |
Methylgene Inc |
INHIBITORS OF THE ACTIVITY OF PROTEIN TIROSINA QUINASA
|
WO2007118704A2
(en)
|
2006-04-17 |
2007-10-25 |
Epigenomics Ag |
Methods and nucleic acids for the detection of colorectal cell proliferative disorders
|
WO2008035209A2
(en)
*
|
2006-05-30 |
2008-03-27 |
Methylgene Inc. |
Inhibitors of protein tyrosine kinase activity
|
EP2634265B1
(en)
|
2006-07-21 |
2016-09-14 |
Epigenomics AG |
Methods related to the gene GLI3 for detection of colorectal cancer
|
US20080255155A1
(en)
*
|
2006-10-18 |
2008-10-16 |
Stephane Raeppel |
Kinase inhibitors and uses thereof
|
US20100203514A1
(en)
|
2006-11-24 |
2010-08-12 |
Sledziewski Andrew Z |
Methods and nucleic acids for the analysis of gene expression associated with the development of prostate cell proliferative disorders
|
CA2675895C
(en)
|
2007-01-19 |
2016-03-22 |
Epigenomics Ag |
Methods and nucleic acids for analyses of cell proliferative disorders
|
EP2302069A1
(en)
|
2007-12-11 |
2011-03-30 |
Epigenomics AG |
Methods and nucleic acids for analyses of cell proliferative disorders
|
US8293897B2
(en)
|
2008-10-14 |
2012-10-23 |
Ning Xi |
Compounds comprising a spiro-ring and methods of use
|
WO2010065671A2
(en)
|
2008-12-04 |
2010-06-10 |
Curna, Inc. |
Treatment of vascular endothelial growth factor (vegf) related diseases by inhibition of natural antisense transcript to vegf
|
US20110294870A1
(en)
|
2008-12-04 |
2011-12-01 |
Opko Curna, Llc |
Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
|
ES2629630T3
(en)
|
2008-12-04 |
2017-08-11 |
Curna, Inc. |
Treatment of diseases related to erythropoietin (EPO) by inhibiting the natural antisense transcript to EPO
|
ES2762610T3
(en)
|
2009-02-12 |
2020-05-25 |
Curna Inc |
Treatment of diseases related to brain-derived neurotrophic factor (BDNF) by inhibition of natural antisense transcript for BDNF
|
MX2011009751A
(en)
|
2009-03-16 |
2011-09-29 |
Opko Curna Llc |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2.
|
WO2010107740A2
(en)
|
2009-03-17 |
2010-09-23 |
Curna, Inc. |
Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
|
JP6250930B2
(en)
|
2009-05-06 |
2017-12-20 |
クルナ・インコーポレーテッド |
Treatment of TTP-related diseases by suppression of natural antisense transcripts against tristetraproline (TTP)
|
CN102459596B
(en)
|
2009-05-06 |
2016-09-07 |
库尔纳公司 |
By suppression therapy lipid transfer and the metabolic gene relevant disease of the natural antisense transcript for lipid transfer and metabolic gene
|
KR101742334B1
(en)
|
2009-05-08 |
2017-06-01 |
큐알엔에이, 인크. |
Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to dmd family
|
CN102575251B
(en)
|
2009-05-18 |
2018-12-04 |
库尔纳公司 |
The relevant disease of the reprogramming factor is treated by inhibiting the natural antisense transcript for the reprogramming factor
|
KR101703695B1
(en)
|
2009-05-22 |
2017-02-08 |
큐알엔에이, 인크. |
Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3
|
CN103221541B
(en)
|
2009-05-28 |
2017-03-01 |
库尔纳公司 |
Antiviral gene relevant disease is treated by the natural antisense transcript suppressing antiviral gene
|
KR101702689B1
(en)
|
2009-06-16 |
2017-02-06 |
큐알엔에이, 인크. |
Treatment of paraoxonase 1 (pon1) related diseases by inhibition of natural antisense transcript to pon1
|
WO2010148050A2
(en)
|
2009-06-16 |
2010-12-23 |
Curna, Inc. |
Treatment of collagen gene related diseases by inhibition of natural antisense transcript to a collagen gene
|
CA2765889A1
(en)
|
2009-06-24 |
2010-12-29 |
Opko Curna, Llc |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
CA2765815A1
(en)
|
2009-06-26 |
2010-12-29 |
Opko Curna, Llc |
Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
|
AR077238A1
(en)
|
2009-06-26 |
2011-08-10 |
Unilever Nv |
COMPOSITIONS FOR ORAL CARE. USE OF A POLYMER TO MANUFACTURE THE COMPOSITION
|
CA2768947C
(en)
|
2009-07-24 |
2018-06-19 |
Opko Curna, Llc |
Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
|
US9234199B2
(en)
|
2009-08-05 |
2016-01-12 |
Curna, Inc. |
Treatment of insulin gene (INS) related diseases by inhibition of natural antisense transcript to an insulin gene (INS)
|
EP2464731B1
(en)
|
2009-08-11 |
2016-10-05 |
CuRNA, Inc. |
Treatment of adiponectin (adipoq) related diseases by inhibition of natural antisense transcript to an adiponectin (adipoq)
|
WO2011022606A2
(en)
|
2009-08-21 |
2011-02-24 |
Curna, Inc. |
Treatment of 'c terminus of hsp70-interacting protein' (chip) related diseases by inhibition of natural antisense transcript to chip
|
CN102482671B
(en)
|
2009-08-25 |
2017-12-01 |
库尔纳公司 |
IQGAP relevant diseases are treated by suppressing the natural antisense transcript of ' gtpase activating protein containing IQ die bodys ' (IQGAP)
|
EP2480669B1
(en)
|
2009-09-25 |
2017-11-08 |
CuRNA, Inc. |
Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
|
US20110104695A1
(en)
|
2009-11-05 |
2011-05-05 |
Epigenomics Ag |
Methods of predicting therapeutic efficacy of cancer therapy
|
ES2661813T3
(en)
|
2009-12-16 |
2018-04-04 |
Curna, Inc. |
Treatment of diseases related to membrane transcription factor peptidase, site 1 (mbtps1) by inhibition of the natural antisense transcript to the mbtps1 gene
|
US9068183B2
(en)
|
2009-12-23 |
2015-06-30 |
Curna, Inc. |
Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2
|
CA2782373C
(en)
|
2009-12-23 |
2019-03-26 |
Opko Curna, Llc |
Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf
|
WO2011090740A2
(en)
|
2009-12-29 |
2011-07-28 |
Opko Curna, Llc |
Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
|
ES2585829T3
(en)
|
2009-12-29 |
2016-10-10 |
Curna, Inc. |
Treatment of diseases related to tumor protein 63 (p63) by inhibition of natural antisense transcription to p63
|
US20120289583A1
(en)
|
2009-12-31 |
2012-11-15 |
Curna, Inc. |
Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
|
KR101878501B1
(en)
|
2010-01-04 |
2018-08-07 |
큐알엔에이, 인크. |
Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8
|
EP2521785B1
(en)
|
2010-01-06 |
2022-03-09 |
CuRNA, Inc. |
Inhibition of natural antisense transcript to a pancreatic developmental gene for use in a treatment of pancreatic developmental gene related diseases
|
DK2524039T3
(en)
|
2010-01-11 |
2018-03-12 |
Curna Inc |
TREATMENT OF GENDER HORMON-BINDING GLOBULIN (SHBG) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPTS TO SHBG
|
CN102782135A
(en)
|
2010-01-25 |
2012-11-14 |
库尔纳公司 |
Treatment of RNase H1 related diseases by inhibition of natural antisense transcript to RNase H1
|
CN102844435B
(en)
|
2010-02-22 |
2017-05-10 |
库尔纳公司 |
Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
|
ES2657969T3
(en)
|
2010-04-02 |
2018-03-07 |
Curna, Inc. |
Treatment of diseases related to Colony Stimulating Factor 3 (CSF3) by inhibition of the natural antisense transcript to CSF3
|
RU2610661C2
(en)
|
2010-04-09 |
2017-02-14 |
Курна, Инк. |
Treatment of fibroblast growth factor 21 (fgf21) related diseases by inhibition of natural antisense transcript to fgf21
|
CN107988228B
(en)
|
2010-05-03 |
2022-01-25 |
库尔纳公司 |
Treatment of Sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to Sirtuin (SIRT)
|
TWI531370B
(en)
|
2010-05-14 |
2016-05-01 |
可娜公司 |
Treatment of par4 related diseases by inhibition of natural antisense transcript to par4
|
US8895528B2
(en)
|
2010-05-26 |
2014-11-25 |
Curna, Inc. |
Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
|
CA2799596C
(en)
|
2010-05-26 |
2020-09-22 |
Curna, Inc. |
Treatment of methionine sulfoxide reductase a (msra) related diseases by inhibition of natural antisense transcript to msra
|
KR102008708B1
(en)
|
2010-06-23 |
2019-08-08 |
큐알엔에이, 인크. |
Treatment of sodium channel voltage-gated, alpha subunit (scna) related diseases by inhibition of natural abtisense transcript to scna
|
CN103068982B
(en)
|
2010-07-14 |
2017-06-09 |
库尔纳公司 |
DLG relevant diseases are treated by suppressing the natural antisense transcript of the big homologue of plate-like (DLG)
|
EP2625274B1
(en)
|
2010-10-06 |
2017-07-19 |
CuRNA, Inc. |
Treatment of sialidase 4 (neu4) related diseases by inhibition of natural antisense transcript to neu4
|
CA2815212A1
(en)
|
2010-10-22 |
2012-04-26 |
Curna, Inc. |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
WO2012068340A2
(en)
|
2010-11-18 |
2012-05-24 |
Opko Curna Llc |
Antagonat compositions and methods of use
|
CN103459599B
(en)
|
2010-11-23 |
2017-06-16 |
库尔纳公司 |
NANOG relevant diseases are treated by suppressing the natural antisense transcript of NANOG
|
RU2568258C2
(en)
|
2011-02-28 |
2015-11-20 |
Саншайн Лейк Фарма Ко., Лтд |
Substituted quinoline compounds and methods of their application
|
JP6188686B2
(en)
|
2011-06-09 |
2017-08-30 |
カッパーアールエヌエー,インコーポレイテッド |
Treatment of FXN-related diseases by inhibition of natural antisense transcripts to frataxin (FXN)
|
MX358117B
(en)
|
2011-07-08 |
2018-08-06 |
Epigenomics Ag |
Methods and nucleic acids for determining the prognosis of a cancer subject.
|
AU2012302051B2
(en)
|
2011-08-30 |
2017-04-27 |
Astex Pharmaceuticals, Inc. |
Decitabine derivative formulations
|
CA2847811C
(en)
|
2011-09-06 |
2019-10-22 |
Curna, Inc. |
Treatment of diseases related to alpha subunits of sodium channels, voltage-gated (scnxa) with small molecules
|
US20150031750A1
(en)
|
2012-03-15 |
2015-01-29 |
The Scripps Research Institute |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
AU2013296897B2
(en)
|
2012-07-28 |
2015-09-17 |
Beijing Findcure Biosciences Ltd. |
Substituted pyrazolone compounds and methods of use
|
TWI574962B
(en)
|
2012-11-14 |
2017-03-21 |
加拓科學公司 |
Heteroaromatic compounds as pi3 kinase modulators and methods of use
|
SG11201505493QA
(en)
|
2013-02-21 |
2015-08-28 |
Calitor Sciences Llc |
Heteroaromatic compounds as pi3 kinase modulators
|
EP2971169A4
(en)
|
2013-03-13 |
2016-10-26 |
Abbott Molecular Inc |
Systems and methods for isolating nucleic acids
|
EP2971171A4
(en)
|
2013-03-14 |
2016-11-02 |
Abbott Molecular Inc |
Multiplex methylation-specific amplification systems and methods
|
CA2902916C
(en)
|
2013-03-14 |
2018-08-28 |
Mayo Foundation For Medical Education And Research |
Detecting neoplasm
|
WO2015124921A1
(en)
|
2014-02-19 |
2015-08-27 |
The University Court Of The University Of Edinburgh |
Methods and uses for determining the presence of inflammatory bowel disease
|
EP3126519A4
(en)
|
2014-03-31 |
2018-01-17 |
Mayo Foundation for Medical Education and Research |
Detecting colorectal neoplasm
|
US10465248B2
(en)
|
2014-12-12 |
2019-11-05 |
Exact Sciences Development Company, Llc |
Method of characterizing ZDHHC1 DNA
|
US10435755B2
(en)
|
2015-03-27 |
2019-10-08 |
Exact Sciences Development Company, Llc |
Detecting esophageal disorders
|
EP3316685A4
(en)
|
2015-07-02 |
2019-03-13 |
Otsuka Pharmaceutical Co., Ltd. |
Lyophilized pharmaceutical compositions
|
KR102627044B1
(en)
|
2015-10-19 |
2024-01-18 |
선샤인 레이크 파르마 컴퍼니 리미티드 |
Salts of EGFR inhibitors, their crystalline forms and uses
|
US10822638B2
(en)
|
2015-10-30 |
2020-11-03 |
Exact Sciences Development Company, Llc |
Isolation and detection of DNA from plasma
|
KR20170050916A
(en)
*
|
2015-11-02 |
2017-05-11 |
연세대학교 산학협력단 |
Method for controlling differentiatin of stem cell by epigenetic modification of intragenic cpg island
|
US10385406B2
(en)
|
2016-05-05 |
2019-08-20 |
Exact Sciences Development Company, Llc |
Detection of lung neoplasia by analysis of methylated DNA
|
EP3488004B1
(en)
|
2016-07-19 |
2021-10-06 |
Exact Sciences Development Company, LLC |
Methylated control dna
|
KR20240038151A
(en)
|
2016-09-02 |
2024-03-22 |
메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 |
Detecting hepatocellular carcinoma
|
US11118228B2
(en)
|
2017-01-27 |
2021-09-14 |
Exact Sciences Development Company, Llc |
Detection of colon neoplasia by analysis of methylated DNA
|
WO2019025863A2
(en)
|
2017-08-03 |
2019-02-07 |
Otsuka Pharmaceutical Co., Ltd. |
Drug compound and purification methods thereof
|
EP3880847A2
(en)
|
2018-11-16 |
2021-09-22 |
Oslo Universitetssykehus HF |
Methods and compositions for characterizing bladder cancer
|
CN111321210B
(en)
*
|
2018-12-13 |
2021-09-14 |
贵阳优乐复生医学检验所有限公司 |
Method for non-invasive prenatal detection of whether fetus suffers from genetic disease
|
CA3154354A1
(en)
|
2019-10-31 |
2021-05-06 |
William R. Taylor |
Detecting ovarian cancer
|
WO2022040306A1
(en)
|
2020-08-19 |
2022-02-24 |
Mayo Foundation For Medical Education And Research |
Detecting non-hodgkin lymphoma
|
WO2022165247A1
(en)
|
2021-01-29 |
2022-08-04 |
Mayo Foundation For Medical Education And Research |
Detecting the presence or absence of multiple types of cancer
|