ATE165364T1 - Neue kardioaktive 17-iminomethylalkenyl-5-beta-14-beta-androstan und 17-iminoalkyl-5-beta, 14-beta- androstan derivate, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon - Google Patents
Neue kardioaktive 17-iminomethylalkenyl-5-beta-14-beta-androstan und 17-iminoalkyl-5-beta, 14-beta- androstan derivate, ein verfahren zu ihrer herstellung und pharmazeutische präparate davonInfo
- Publication number
- ATE165364T1 ATE165364T1 AT94120242T AT94120242T ATE165364T1 AT E165364 T1 ATE165364 T1 AT E165364T1 AT 94120242 T AT94120242 T AT 94120242T AT 94120242 T AT94120242 T AT 94120242T AT E165364 T1 ATE165364 T1 AT E165364T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- alkyl
- substituted
- unsubstituted
- iminomethylalkenyl
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000000204 (C2-C4) acyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4344236A DE4344236A1 (de) | 1993-12-23 | 1993-12-23 | Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE165364T1 true ATE165364T1 (de) | 1998-05-15 |
Family
ID=6506053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94120242T ATE165364T1 (de) | 1993-12-23 | 1994-12-20 | Neue kardioaktive 17-iminomethylalkenyl-5-beta-14-beta-androstan und 17-iminoalkyl-5-beta, 14-beta- androstan derivate, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5583127A (de) |
| EP (1) | EP0659761B1 (de) |
| JP (1) | JP3545477B2 (de) |
| AT (1) | ATE165364T1 (de) |
| DE (2) | DE4344236A1 (de) |
| ES (1) | ES2115855T3 (de) |
| GR (1) | GR3026694T3 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4420501A1 (de) | 1994-06-13 | 1995-12-14 | Sigma Tau Ind Farmaceuti | Neue Hydrazino- und Hydroxyamino-14beta-hydroxyandrostanderivate mit Aktivität für das cardiovaskuläre System, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die diese enthalten |
| DE4442486A1 (de) * | 1994-11-29 | 1996-05-30 | Sigma Tau Ind Farmaceuti | Neue 17-(3-Imino-2-alkylpropylen)-5ß,14ß-androstan-Derivate, die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
| IT1282289B1 (it) * | 1995-06-23 | 1998-03-16 | Sigma Tau Ind Farmaceuti | 17-idrossiimminoalchil e 17-idrossiimminometilalchenil ciclopentaperidrofenantreni attivi sul sistema cardiovascolare, |
| DE19633349A1 (de) * | 1996-08-19 | 1998-02-26 | Sigma Tau Ind Farmaceuti | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
| WO2026010464A1 (ko) * | 2024-07-05 | 2026-01-08 | 주식회사 큐라클 | 혈관내피 기능장애 치료제 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2571727B1 (fr) * | 1984-10-16 | 1987-06-12 | Roussel Uclaf | Nouveaux produits steroides comportant, en position 23, un radical dihydro oxazolyle, leur procede de preparation, leur application a la preparation de produits de la serie des 20 cetopregnanes et intermediaires de cette application |
-
1993
- 1993-12-23 DE DE4344236A patent/DE4344236A1/de not_active Ceased
-
1994
- 1994-12-20 ES ES94120242T patent/ES2115855T3/es not_active Expired - Lifetime
- 1994-12-20 EP EP94120242A patent/EP0659761B1/de not_active Expired - Lifetime
- 1994-12-20 DE DE69409774T patent/DE69409774T2/de not_active Expired - Fee Related
- 1994-12-20 AT AT94120242T patent/ATE165364T1/de not_active IP Right Cessation
- 1994-12-23 US US08/363,060 patent/US5583127A/en not_active Expired - Lifetime
- 1994-12-26 JP JP33674194A patent/JP3545477B2/ja not_active Expired - Fee Related
-
1998
- 1998-04-22 GR GR980400850T patent/GR3026694T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69409774D1 (de) | 1998-05-28 |
| JPH07267983A (ja) | 1995-10-17 |
| JP3545477B2 (ja) | 2004-07-21 |
| EP0659761A2 (de) | 1995-06-28 |
| HK1009333A1 (en) | 1999-05-28 |
| US5583127A (en) | 1996-12-10 |
| ES2115855T3 (es) | 1998-07-01 |
| DE4344236A1 (de) | 1995-06-29 |
| GR3026694T3 (en) | 1998-07-31 |
| EP0659761B1 (de) | 1998-04-22 |
| EP0659761A3 (de) | 1995-12-13 |
| DE69409774T2 (de) | 1998-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |